Protein: PPARA
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)

Gene: PPARA
Organism: Homo sapiens
Interactions: 94
UniProt ID: Q07869

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001216 - DNA-binding transcription activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1060607

NCOA1
Nuclear receptor coactivator 1

7

20

Small-scale

0.955

High

625800

RXRA
Retinoic acid receptor RXR-alpha

7

20

Small-scale

0.953

High

1060602

NR1H3
Oxysterols receptor LXR-alpha

3

19

Small-scale

0.879

High

461398

HS90A
Heat shock protein HSP 90-alpha

2

20

Small-scale

0.807

High

873153

RXRG
Retinoic acid receptor RXR-gamma

2

20

Small-scale

0.793

High

1060605

NCOA2
Nuclear receptor coactivator 2

2

20

Small-scale

0.778

High

278317

NCOR1
Nuclear receptor corepressor 1

6

20

Small-scale

0.733

High

933937

NR1H2
Oxysterols receptor LXR-beta

1

20

Small-scale

0.692

High

1060600

EP300
Histone acetyltransferase p300

4

20

Small-scale

0.686

High

1060644

NCOA3
Nuclear receptor coactivator 3

1

20

Small-scale

0.647

High

1060615

HUWE1
E3 ubiquitin-protein ligase HUWE1

3

13

Small-scale

0.640

High

987576

GRB2
Growth factor receptor-bound protein 2

2

17

High-throughput

0.634

High

1060643

NCOR2
Nuclear receptor corepressor 2

2

20

Small-scale

0.633

High

704518

RXRB
Retinoic acid receptor RXR-beta

1

20

Small-scale

0.618

High

1060640

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

2

20

Small-scale

0.602

High

1060606

MED1
Mediator of RNA polymerase II transcription subunit 1

2

20

Small-scale

0.584

High

1060626

STAC3
SH3 and cysteine-rich domain-containing protein 3

2

12

High-throughput

0.584

High

1060608

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

20

Small-scale

0.578

High

124768

AIP
AH receptor-interacting protein

1

9

Small-scale

0.561

High

522080

BCL2
Apoptosis regulator Bcl-2

1

5

Small-scale

0.561

High

1060624

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

20

Small-scale

0.561

High

1060621

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

19

High-throughput

0.542

High

938013

FOXA3
Hepatocyte nuclear factor 3-gamma

1

20

High-throughput

0.541

High

1025257

CDK3
Cyclin-dependent kinase 3

1

9

High-throughput

0.541

High

993522

UBC9
SUMO-conjugating enzyme UBC9

1

9

Small-scale

0.536

High

390021

ALBU
Albumin

1

2

High-throughput

0.515

High

562020

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.515

High

788905

TGFR2
TGF-beta receptor type-2

1

2

High-throughput

0.515

High

843507

HD
Huntingtin

1

4

High-throughput

0.515

High

853232

CBX5
Chromobox protein homolog 5

1

19

High-throughput

0.515

High

931505

RD23A
UV excision repair protein RAD23 homolog A

1

16

High-throughput

0.515

High

934521

TERA
Transitional endoplasmic reticulum ATPase

1

10

High-throughput

0.515

High

936989

CASP6
Caspase-6

1

5

High-throughput

0.515

High

981469

RAN
GTP-binding nuclear protein Ran

1

9

High-throughput

0.515

High

1060614

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

9

High-throughput

0.515

High

1060611

PAQR3
Progestin and adipoQ receptor family member 3

1

2

Small-scale

0.512

High

1060631

ANM1
Protein arginine N-methyltransferase 1

1

20

High-throughput

0.508

High

282373

MED24
Mediator of RNA polymerase II transcription subunit 24

1

7

Small-scale

0.501

High

332148

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

8

Small-scale

0.501

High

700823

PIT1
Pituitary-specific positive transcription factor 1

1

20

Small-scale

0.501

High

873945

NRIP1
Nuclear receptor-interacting protein 1

1

17

Small-scale

0.501

High

883225

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

Small-scale

0.501

High

902455

RT29
Small ribosomal subunit protein mS29

1

2

Small-scale

0.501

High

1045213

TF65
Transcription factor p65

1

20

Small-scale

0.501

High

1060601

AKP13
A-kinase anchor protein 13

1

20

Small-scale

0.501

High

1060610

CE350
Centrosome-associated protein 350

1

13

Small-scale

0.501

High

1060617

PRGC2
Peroxisome proliferator-activated receptor gamma coactivator 1-beta

1

20

Small-scale

0.501

High

1060622

CBP
CREB-binding protein

1

20

Small-scale

0.501

High

1060632

MECR
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

1

4

Small-scale

0.501

High

1060633

HELZ2
3'-5' exoribonuclease HELZ2

1

12

Small-scale

0.501

High

219159

LTOR5
Ragulator complex protein LAMTOR5

1

2

High-throughput

0.494

High

139394

VMA5A
von Willebrand factor A domain-containing protein 5A

1

2

High-throughput

0.481

High

140239

SDCB1
Syntenin-1

1

17

High-throughput

0.481

High

450479

FABPL
Fatty acid-binding protein, liver

1

9

Small-scale

0.481

High

481436

STP1
Spermatid nuclear transition protein 1

1

2

Small-scale

0.481

High

654493

FBLN1
Fibulin-1

1

9

High-throughput

0.481

High

725046

HXC8
Homeobox protein Hox-C8

1

20

High-throughput

0.481

High

1060609

ZSC23
Zinc finger and SCAN domain-containing protein 23

1

8

High-throughput

0.481

High

1060612

ANR11
Ankyrin repeat domain-containing protein 11

1

17

High-throughput

0.481

High

1060619

FAM9B
Protein FAM9B

1

1

High-throughput

0.481

High

1060623

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.481

High

1060625

NRBF2
Nuclear receptor-binding factor 2

1

3

Small-scale

0.481

High

1060629

ZN587
Zinc finger protein 587

1

5

High-throughput

0.481

High

1060634

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.481

High

1060636

EXOS4
Exosome complex component RRP41

1

12

High-throughput

0.481

High

1060638

PICK1
PRKCA-binding protein

1

2

High-throughput

0.481

High

822631

VHL
von Hippel-Lindau disease tumor suppressor

1

3

Small-scale

0.479

High

838074

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

20

Small-scale

0.479

High

938094

ANM2
Protein arginine N-methyltransferase 2

1

20

Small-scale

0.479

High

1060603

LPIN1
Phosphatidate phosphatase LPIN1

1

1

Small-scale

0.479

High

1060628

TRIB3
Tribbles homolog 3

1

16

Small-scale

0.479

High

1060635

ILRUN
Protein ILRUN

1

1

Small-scale

0.479

High

47322

A0A6Q8PF08
Peripheral myelin protein 22

1

1

High-throughput

0.470

High

109393

G5E9A7
DM1 locus, WD repeat containing

1

20

High-throughput

0.470

High

442305

GELS
Gelsolin

1

9

High-throughput

0.470

High

650139

FGFR3
Fibroblast growth factor receptor 3

1

7

High-throughput

0.470

High

1060604

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

3

High-throughput

0.470

High

1060620

JPH3
Junctophilin-3

1

6

High-throughput

0.470

High

1060637

ANM8
Protein arginine N-methyltransferase 8

1

20

High-throughput

0.464

High

715887

AQP1
Aquaporin-1

1

0

High-throughput

0.460

High

74117

VWC2L
von Willebrand factor C domain-containing protein 2-like

1

4

High-throughput

0.439

High

350449

GPAN1
G patch domain and ankyrin repeat-containing protein 1

1

13

High-throughput

0.439

High

949690

KR101
Keratin-associated protein 10-1

1

20

High-throughput

0.439

High

1060627

KCTD7
BTB/POZ domain-containing protein KCTD7

1

10

High-throughput

0.439

High

1060641

CTNA3
Catenin alpha-3

1

3

High-throughput

0.439

High

1060613

PAQR9
Membrane progestin receptor epsilon

1

2

Small-scale

0.437

High

1060618

ZDH23
Palmitoyltransferase ZDHHC23

1

5

Small-scale

0.437

High

1060639

ZDH18
Palmitoyltransferase ZDHHC18

1

2

Small-scale

0.437

High

441535

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

116358

CC179
Coiled-coil domain-containing protein 179

1

0

High-throughput

0.251

Low

694330

CO8A1
Collagen alpha-1(VIII) chain

1

0

High-throughput

0.251

Low

1060616

F90A1
Protein FAM90A1

1

0

High-throughput

0.251

Low

1060642

CHIC2
Cysteine-rich hydrophobic domain-containing protein 2

1

0

High-throughput

0.251

Low

1060630

EBP2
Probable rRNA-processing protein EBP2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025