HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: SYNE2 (Q8WXH0)
Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2)
Gene: SYNE2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12118075
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Actin~CH
Common GO terms	GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 6885
+	Oc
		996588 ACTS_RABIT (1-377): 0: 599: 98.94		Q07931_RABIT (20-313): 2.31e-114: 368: 34.46
+	Hs
		953039 ACTB_HUMAN (4-377): 0: 598: 94.12		CLMN_HUMAN (18-283): 7.66e-50: 198: 47.06
+	Hs
		995607 ACTC_HUMAN (1-377): 0: 599: 100.00		PLEC_HUMAN (1306-3781): 6.32e-48: 195: 9.10
+	Hs
		996459 ACTS_HUMAN (1-377): 0: 599: 98.94		PLEC_HUMAN (1306-3781): 6.32e-48: 195: 9.10
+	Hs
		952834 ACTB_HUMAN (4-377): 0: 598: 94.12		PLEC_HUMAN (1306-3781): 6.32e-48: 195: 9.10
+	Hs
		993183 ACTG_HUMAN (4-377): 0: 598: 94.39		PLEC_HUMAN (1306-3781): 6.32e-48: 195: 9.10
+	Hs
		977703 ACTA_HUMAN (1-377): 0: 597: 98.41		PLEC_HUMAN (1306-3781): 6.32e-48: 195: 9.10
+	Dm
		305328 ACT1_DROME (1-377): 0: 598: 94.43		O77291_DROME (2-289): 1.16e-46: 190: 40.14
+	Hs
		862631 ACTC_HUMAN (1-377): 0: 599: 100.00		UTRN_HUMAN (4629-6845): 4.74e-29: 132: 9.81
+	Hs
		540248 ACTB_HUMAN (4-377): 0: 598: 94.12		SPTB1_HUMAN (3114-4757): 1.35e-27: 127: 8.99
+	Hs
		995543 ACTC_HUMAN (1-377): 0: 599: 100.00		SPTB2_HUMAN (5537-6835): 6.21e-24: 115: 9.45
+	Hs
		952750 ACTB_HUMAN (4-377): 0: 598: 94.12		SPTB2_HUMAN (5537-6835): 6.21e-24: 115: 9.45
+	Hs
		993135 ACTG_HUMAN (4-377): 0: 598: 94.39		SPTB2_HUMAN (5537-6835): 6.21e-24: 115: 9.45
+	Hs
		995549 ACTC_HUMAN (1-377): 0: 599: 100.00		DYST_HUMAN (5367-6840): 5.03e-21: 105: 10.19
+	Hs
		996432 ACTS_HUMAN (1-377): 0: 599: 98.94		DYST_HUMAN (5367-6840): 5.03e-21: 105: 10.19
+	Hs
		952759 ACTB_HUMAN (4-377): 0: 598: 94.12		DYST_HUMAN (5367-6840): 5.03e-21: 105: 10.19
+	Hs
		993139 ACTG_HUMAN (4-377): 0: 598: 94.39		DYST_HUMAN (5367-6840): 5.03e-21: 105: 10.19
+	Hs
		174729 ACTB_HUMAN (4-377): 0: 598: 94.12		SPTN2_HUMAN (3531-5279): 9.06e-16: 88.3: 8.43
+	Hs
		547432 ACTS_HUMAN (1-377): 0: 599: 98.94		DMD_HUMAN (5693-6857): 1.34e-12: 77.9: 11.20
+	Hs
		953184 ACTB_HUMAN (4-377): 0: 598: 94.12		MACF1_HUMAN (5906-6858): 3.06e-10: 70.2: 10.46