HitPredict

Interactor 1: H33 (P84244)
Histone H3.3
Gene: H3-3a

Interactor 2: ATRX (Q61687)
Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (HP1 alpha-interacting protein) (HP1-BP38 protein) (Heterochromatin protein 2) (X-linked nuclear protein)
Gene: ATRX

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	20211137
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0006334 - nucleosome assembly GO:0007283 - spermatogenesis GO:0031509 - subtelomeric heterochromatin formation and 1 others more... GO:0035264 - multicellular organism growth
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Mm			1 2476
+	Hs
		802419 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		ATRX_HUMAN (1-2476): 0: 1016: 80.87
+	Hs
		802423 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		ATRX_HUMAN (1-2476): 0: 1016: 80.87
+	Hs
		935281 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		HELLS_HUMAN (1332-2228): 3.15e-146: 480: 18.76
+	Hs
		935234 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SMRCD_HUMAN (1051-2192): 2.58e-135: 454: 17.47
+	Hs
		934759 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		HLTF_HUMAN (1320-2193): 4.48e-126: 427: 16.10
+	Hs
		952334 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		HLTF_HUMAN (1320-2193): 4.48e-126: 427: 16.10
+	Hs
		846921 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SMCA4_HUMAN (1995-2258): 1.13e-68: 259: 25.50
+	Hs
		846925 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		SMCA4_HUMAN (1995-2258): 1.13e-68: 259: 25.50
+	Hs
		935434 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		RA54B_HUMAN (2066-2199): 7.81e-24: 112: 41.26
+	Hs
		934683 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		ERCC6_HUMAN (1544-1837): 3.88e-17: 90.9: 27.36
+	Hs
		952286 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		ERCC6_HUMAN (1544-1837): 3.88e-17: 90.9: 27.36
+	Mm
		935460 H31_MOUSE (1-136): 3.08e-60: 183: 96.32		SMCA5_MOUSE (1572-1872): 5.17e-14: 80.5: 28.29
+	Mm
		952763 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		SMCA5_MOUSE (1572-1872): 5.17e-14: 80.5: 28.29
+	Hs
		229359 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SMCA5_HUMAN (1572-1872): 1.16e-13: 79.3: 27.96
+	Hs
		229363 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		SMCA5_HUMAN (1572-1872): 1.16e-13: 79.3: 27.96
+	Hs
		934770 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CHD4_HUMAN (166-378): 7.45e-13: 76.9: 14.29
+	Hs
		935016 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CHD5_HUMAN (166-370): 1.06e-12: 76.6: 14.67
+	Mm
		56901 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		CHD5_MOUSE (99-370): 5e-12: 74.3: 13.61
+	Hs
		934705 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CHD3_HUMAN (166-377): 2.11e-11: 72.3: 13.87
+	Hs
		952302 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		CHD3_HUMAN (166-377): 2.11e-11: 72.3: 13.87