HitPredict

Interactor 1: HXD13 (P70217)
Homeobox protein Hox-D13 (Homeobox protein Hox-4.8)
Gene: Hoxd13

Interactor 2: SMAD5 (P97454)
Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (Dwarfin-C) (Dwf-C) (SMAD family member 5) (SMAD 5) (Smad5) (mSmad5)
Gene: SMAD5

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	16087734
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 339 Mm			1 465
+	Mm
		999935 HXD13_MOUSE (1-339): 8.02e-71: 225: 100.00		SMAD1_MOUSE (3-465): 0: 634: 89.46
+	Mm
		1021457 HXA13_MOUSE (101-337): 8.31e-31: 121: 47.72		SMAD5_MOUSE (1-465): 0: 651: 100.00
+	Mm
		999939 HXD13_MOUSE (1-339): 8.02e-71: 225: 100.00		SMAD2_MOUSE (4-465): 0: 545: 55.80
+	Mm
		1000229 HXA13_MOUSE (101-337): 8.31e-31: 121: 47.72		SMAD1_MOUSE (3-465): 0: 634: 89.46
+	Hs
		725055 HXC8_HUMAN (123-339): 9.82e-30: 115: 21.56		SMAD1_HUMAN (3-465): 0: 634: 89.03
+	Dm
		393629 ANTP_DROME (131-339): 1.6e-32: 126: 21.50		MAD_DROME (1-465): 0: 609: 72.04
+	Dm
		713654 ABDA_DROME (261-336): 6.38e-31: 124: 43.42		MAD_DROME (1-465): 0: 609: 72.04
+	Dm
		837131 UBX_DROME (111-336): 1.18e-28: 116: 19.03		MAD_DROME (1-465): 0: 609: 72.04
+	Hs
		211226 HXC11_HUMAN (88-332): 2.17e-33: 126: 23.79		SMAD3_HUMAN (4-465): 0: 560: 58.76
+	Hs
		893815 MEOX2_HUMAN (95-339): 1.37e-29: 116: 17.32		SMAD3_HUMAN (4-465): 0: 560: 58.76
+	Dm
		478940 ABDB_DROME (273-329): 3.85e-10: 62.8: 54.39		MAD_DROME (1-465): 0: 609: 72.04
+	Mm
		1224172 HXA13_MOUSE (101-337): 8.31e-31: 121: 47.72		SMAD2_MOUSE (4-465): 0: 545: 55.80
+	Dm
		355854 UBX_DROME (111-336): 1.18e-28: 116: 19.03		O96660_DROME (7-465): 3.64e-178: 509: 50.60
+	Dm
		1014355 UBX_DROME (111-336): 1.18e-28: 116: 19.03		Q9TZQ2_DROME (7-465): 1.94e-177: 507: 50.60
+	Hs
		724995 HXA9_HUMAN (77-332): 1.2e-30: 118: 19.10		SMAD4_HUMAN (14-461): 8.48e-151: 442: 34.52
+	Hs
		725050 HXC8_HUMAN (123-339): 9.82e-30: 115: 21.56		SMAD4_HUMAN (14-461): 8.48e-151: 442: 34.52
+	Hs
		219842 HXC8_HUMAN (123-339): 9.82e-30: 115: 21.56		SMAD6_HUMAN (37-443): 4.94e-102: 315: 26.90
+	Ce
		760668 PAL1_CAEEL (270-335): 3.6e-09: 58.9: 40.91		SMA3_CAEEL (4-200): 3.09e-55: 190: 43.63