Protein: FADD
FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)

Gene: FADD
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q13158

Gene Ontology (top 5):
GO:0001822 - kidney development
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002020 - protease binding
GO:0002821 - positive regulation of adaptive immune response
GO:0005123 - death receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1026619

CASP8
Caspase-8

59

20

Small-scale

0.997

High

632266

TNR6
Tumor necrosis factor receptor superfamily member 6

35

20

Small-scale

0.994

High

1026616

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

33

20

Small-scale

0.993

High

181608

CFLAR
CASP8 and FADD-like apoptosis regulator

13

16

Small-scale

0.981

High

1026623

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

14

5

Small-scale

0.980

High

121480

TR10A
Tumor necrosis factor receptor superfamily member 10A

13

20

Small-scale

0.977

High

154354

TR10B
Tumor necrosis factor receptor superfamily member 10B

13

20

Small-scale

0.977

High

1026611

FADD
FAS-associated death domain protein

10

16

Small-scale

0.970

High

1026639

CASPA
Caspase-10

7

20

Small-scale

0.968

High

1026669

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

7

18

Small-scale

0.949

High

584395

TNR1A
Tumor necrosis factor receptor superfamily member 1A

6

20

Small-scale

0.928

High

271698

DEDD
Death effector domain-containing protein

3

6

Small-scale

0.857

High

1026645

MYD88
Myeloid differentiation primary response protein MyD88

3

7

Small-scale

0.829

High

861730

PLK1
Serine/threonine-protein kinase PLK1

1

2

Small-scale

0.794

High

1026621

PEA15
Astrocytic phosphoprotein PEA-15

2

1

Small-scale

0.768

High

841068

TNF10
Tumor necrosis factor ligand superfamily member 10

16

16

Small-scale

0.759

High

862033

DAPK1
Death-associated protein kinase 1

2

10

Small-scale

0.754

High

1026654

PIDD1
p53-induced death domain-containing protein 1

2

5

Small-scale

0.754

High

815677

TNFL6
Tumor necrosis factor ligand superfamily member 6

6

16

Small-scale

0.726

High

167533

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

9

High-throughput

0.691

High

822007

KC1A
Casein kinase I isoform alpha

1

2

High-throughput

0.691

High

822252

KC1D
Casein kinase I isoform delta

1

2

High-throughput

0.691

High

1026627

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

Small-scale

0.691

High

1026657

IL37
Interleukin-37

3

3

High-throughput

0.667

High

983821

KPCZ
Protein kinase C zeta type

1

4

Small-scale

0.665

High

1026629

ULK3
Serine/threonine-protein kinase ULK3

1

0

High-throughput

0.656

High

599655

TNAP3
Tumor necrosis factor alpha-induced protein 3

3

11

Small-scale

0.656

High

1026670

NEMO
NF-kappa-B essential modulator

2

9

Small-scale

0.628

High

848359

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

Small-scale

0.618

High

1026650

HIPK3
Homeodomain-interacting protein kinase 3

1

6

Small-scale

0.618

High

1026656

NLRC4
NLR family CARD domain-containing protein 4

1

4

Small-scale

0.618

High

1026638

TANK
TRAF family member-associated NF-kappa-B activator

2

4

Small-scale

0.611

High

132844

SDCB1
Syntenin-1

2

2

High-throughput

0.606

High

940847

RNF4
E3 ubiquitin-protein ligase RNF4

2

2

High-throughput

0.606

High

1026632

MAVS
Mitochondrial antiviral-signaling protein

2

4

Small-scale

0.601

High

1026618

NACA
Nascent polypeptide-associated complex subunit alpha

2

0

Small-scale

0.598

High

1026643

PARK7
Parkinson disease protein 7

1

1

Small-scale

0.597

High

846100

RT29
Small ribosomal subunit protein mS29

2

0

Small-scale

0.593

High

547032

EZRI
Ezrin

2

12

Small-scale

0.588

High

1026648

ATG5
Autophagy protein 5

1

4

Small-scale

0.586

High

912786

BTG1
Protein BTG1

2

0

High-throughput

0.580

High

1026641

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

584943

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

Small-scale

0.578

High

1026664

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.578

High

658921

MK01
Mitogen-activated protein kinase 1

1

3

High-throughput

0.575

High

800768

MK08
Mitogen-activated protein kinase 8

1

6

Small-scale

0.575

High

854782

GDIR1
Rho GDP-dissociation inhibitor 1

1

2

Small-scale

0.575

High

214248

SPOP
Speckle-type POZ protein

2

0

Small-scale

0.561

High

919621

RAP1A
Ras-related protein Rap-1A

1

5

Small-scale

0.561

High

1026660

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

1

Small-scale

0.561

High

1026665

FAF1
FAS-associated factor 1

1

2

Small-scale

0.561

High

1026668

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.561

High

1026615

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.537

High

564506

RHOQ
Rho-related GTP-binding protein RhoQ

1

9

High-throughput

0.536

High

929842

ACTG
Actin, cytoplasmic 2

1

5

High-throughput

0.536

High

1026612

PRDX4
Peroxiredoxin-4

1

1

High-throughput

0.536

High

1026620

TNIP1
TNFAIP3-interacting protein 1

1

4

High-throughput

0.536

High

1026626

SDK2
Protein sidekick-2

1

5

High-throughput

0.536

High

1026633

CCD50
Coiled-coil domain-containing protein 50

1

1

High-throughput

0.536

High

1026636

DAAF1
Dynein axonemal assembly factor 1

1

2

High-throughput

0.536

High

1026644

KIF2C
Kinesin-like protein KIF2C

1

2

High-throughput

0.536

High

1026649

E41LB
Band 4.1-like protein 4B

1

12

High-throughput

0.536

High

1026651

RNF41
E3 ubiquitin-protein ligase NRDP1

1

13

High-throughput

0.536

High

1026655

ROBO2
Roundabout homolog 2

1

5

High-throughput

0.536

High

1026667

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.518

High

1026662

C8AP2
CASP8-associated protein 2

1

2

Small-scale

0.515

High

181194

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.513

High

204491

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.513

High

296611

TPPP
Tubulin polymerization-promoting protein

1

0

High-throughput

0.513

High

304719

S1PR2
Sphingosine 1-phosphate receptor 2

1

0

High-throughput

0.513

High

1026625

GOG7B
Golgin subfamily A member 7B

1

0

High-throughput

0.513

High

1026666

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.513

High

1026624

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

1

High-throughput

0.508

High

315249

ABCA1
Phospholipid-transporting ATPase ABCA1

1

0

Small-scale

0.504

High

521903

CADH1
Cadherin-1

1

2

Small-scale

0.501

High

1017372

CDC20
Cell division cycle protein 20 homolog

1

1

Small-scale

0.501

High

499725

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.493

High

589527

SDHL
L-serine dehydratase/L-threonine deaminase

1

0

High-throughput

0.493

High

930187

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.481

High

179934

TLR3
Toll-like receptor 3

1

4

Small-scale

0.479

High

296719

ATG12
Ubiquitin-like protein ATG12

1

1

Small-scale

0.479

High

352602

TNFA
Tumor necrosis factor

1

16

Small-scale

0.479

High

517798

NFH
Neurofilament heavy polypeptide

1

8

High-throughput

0.479

High

672823

CDC27
Cell division cycle protein 27 homolog

1

1

Small-scale

0.479

High

991745

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

3

Small-scale

0.479

High

1020635

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

1021720

GNDS
Ral guanine nucleotide dissociation stimulator

1

5

Small-scale

0.479

High

1026613

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.479

High

1026614

SQSTM
Sequestosome-1

1

9

Small-scale

0.479

High

1026617

CUL3
Cullin-3

1

6

Small-scale

0.479

High

1026630

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1026634

AN13A
Ankyrin repeat domain-containing protein 13A

1

10

Small-scale

0.479

High

1026635

RYBP
RING1 and YY1-binding protein

1

3

Small-scale

0.479

High

1026640

IRF7
Interferon regulatory factor 7

1

4

Small-scale

0.479

High

1026642

CLIP3
CAP-Gly domain-containing linker protein 3

1

7

Small-scale

0.479

High

1026652

XPO5
Exportin-5

1

2

Small-scale

0.479

High

1026653

TNR27
Tumor necrosis factor receptor superfamily member 27

1

3

Small-scale

0.479

High

1026658

DAXX
Death domain-associated protein 6

1

2

Small-scale

0.479

High

1026659

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

1026663

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

20

Small-scale

0.479

High

81894

B7ZLH0
FAM22F protein

1

1

High-throughput

0.470

High

1026631

Q7KZS0
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.470

High

304824

MFN2
Mitofusin-2

1

0

High-throughput

0.458

High

1026646

LRCC1
Leucine-rich repeat and coiled-coil domain-containing protein 1

1

5

High-throughput

0.457

High

354059

IGHA1
Immunoglobulin heavy constant alpha 1

1

2

High-throughput

0.445

High

640096

MOES
Moesin

1

11

Small-scale

0.445

High

879517

BID
BH3-interacting domain death agonist

1

2

Small-scale

0.445

High

900432

RHOA
Transforming protein RhoA

1

9

Small-scale

0.445

High

968299

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

9

High-throughput

0.445

High

50821

NTM2F
NUT family member 2F

1

1

High-throughput

0.439

High

816355

PPCE
Prolyl endopeptidase

1

0

High-throughput

0.426

High

1026647

DDX24
ATP-dependent RNA helicase DDX24

1

4

High-throughput

0.417

High

203124

P52K
52 kDa repressor of the inhibitor of the protein kinase

3

0

High-throughput

0.347

High

1026622

TCEA2
Transcription elongation factor A protein 2

2

0

High-throughput

0.316

High

1026628

ZCH12
Zinc finger CCHC domain-containing protein 12

2

0

High-throughput

0.316

High

1026661

ZMYM5
Zinc finger MYM-type protein 5

2

0

High-throughput

0.316

High

309396

MBD4
Methyl-CpG-binding domain protein 4

1

0

Small-scale

0.305

High

519776

KCRU
Creatine kinase U-type, mitochondrial

1

0

High-throughput

0.279

Low

710106

NTF4
Neurotrophin-4

1

0

High-throughput

0.279

Low

1026637

NDNF
Protein NDNF

1

0

High-throughput

0.279

Low

452759

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024