Protein: U520
U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Protein lethal (3) 72Ab)

Gene: U520, Brr2
Organism: Drosophila melanogaster
Interactions: 44
UniProt ID: Q9VUV9

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000381 - regulation of alternative mRNA splicing, via spliceosome
GO:0000388 - spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
GO:0000398 - mRNA splicing, via spliceosome
GO:0003676 - nucleic acid binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

54637

A1Z8U0
Pre-mRNA-processing-splicing factor 8

3

9

Small-scale

0.817

High

614383

SGG
Protein kinase shaggy

2

14

High-throughput

0.635

High

1486965

ECD
Protein ecdysoneless

3

2

Small-scale

0.633

High

1471286

Q9VD52
Pre-mRNA-processing factor 17

1

20

High-throughput

0.618

High

356911

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

1

16

High-throughput

0.575

High

1268425

Q7KNF1
Ribonuclease 3

1

7

High-throughput

0.575

High

1472099

INO80
Chromatin-remodeling ATPase INO80

1

9

High-throughput

0.575

High

1478222

Q9VJ74
Probable ATP-dependent RNA helicase DDX23

1

19

High-throughput

0.575

High

1483305

Q9VPL0
U5 small nuclear ribonucleoprotein 40 kDa protein

1

20

High-throughput

0.575

High

55551

SYF1
Pre-mRNA-splicing factor syf1 homolog

2

20

High-throughput

0.571

High

1468605

Q9VAX8
116 kDa U5 small nuclear ribonucleoprotein component

2

11

High-throughput

0.571

High

1477191

Q9VI54
LD29489p

2

5

High-throughput

0.571

High

1486016

Q9VT74
U5 small nuclear ribonucleoprotein TSSC4

2

0

High-throughput

0.547

High

1069419

Q0E8K8
FI21816p1

1

9

High-throughput

0.536

High

1047204

KELC
Ring canal kelch protein [Cleaved into: Kelch short protein]

1

1

Small-scale

0.504

High

1440339

Q9I7K8
FI07222p

1

9

High-throughput

0.489

High

1475220

Q9VGU4
FI02822p

1

9

High-throughput

0.489

High

120393

M9PD17
Gigas, isoform B

1

1

High-throughput

0.479

High

305016

CRY1
Cryptochrome-1

1

8

High-throughput

0.479

High

357433

O97454
Protein BUD31 homolog

1

3

High-throughput

0.479

High

814174

BX42
Puff-specific protein Bx42

1

9

High-throughput

0.479

High

1172692

SIMA
Protein similar

1

1

High-throughput

0.479

High

1267795

Q7KMQ6
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

High-throughput

0.479

High

1484674

Q9VR61
non-specific serine/threonine protein kinase

1

4

High-throughput

0.479

High

609152

CRN
Protein crooked neck

1

20

High-throughput

0.445

High

1303631

OSA
Trithorax group protein osa

1

3

High-throughput

0.445

High

1321525

ENC
Protein encore

1

2

High-throughput

0.445

High

1377243

Q95RB1
Pre-mRNA-splicing factor RBM22

1

18

High-throughput

0.445

High

1470134

RRP5
rRNA biogenesis protein RRP5

1

20

High-throughput

0.445

High

1472441

Q9VEA6
Protein AAR2 homolog

1

4

High-throughput

0.445

High

1479861

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2 homolog

1

4

High-throughput

0.445

High

1481118

Q9VLS7
LD21067p

1

2

High-throughput

0.445

High

1470244

Q9VCC9
LD23779p

1

9

High-throughput

0.437

High

1486963

Q9VWJ6
FI03615p

1

2

High-throughput

0.437

High

1486964

DOS
Protein daughter of sevenless

1

18

High-throughput

0.437

High

1304850

Q8IPU8
BNIP3, isoform B

1

0

High-throughput

0.426

High

757183

FAS2
Fasciclin-2

1

1

High-throughput

0.407

High

929597

PDI
Protein disulfide-isomerase

1

2

High-throughput

0.407

High

1266147

Q7K3W2
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.407

High

1268996

Q7KSA2
HIT-type domain-containing protein

1

1

High-throughput

0.407

High

1466578

EPB41
Protein 4.1 homolog

1

3

High-throughput

0.407

High

1480577

PESC
Pescadillo homolog

1

3

High-throughput

0.407

High

1486966

Q9W4M7
Twenty-four, isoform B

1

3

High-throughput

0.407

High

1470643

Q9VCQ7
LD40758p

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025