Protein: SOX2
Transcription factor SOX-2

Gene: SOX2
Organism: Mus musculus
Interactions: 128
UniProt ID: P48432

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

590263

PO5F1
POU domain, class 5, transcription factor 1

6

20

Small-scale

0.947

High

818676

SOX2
Transcription factor SOX-2

2

19

Small-scale

0.754

High

818733

NANOG
Homeobox protein NANOG

4

20

Small-scale

0.694

High

140241

HDAC1
Histone deacetylase 1

4

20

Small-scale

0.694

High

818739

SALL4
Sal-like protein 4

3

20

Small-scale

0.664

High

818695

EYA1
Eyes absent homolog 1

2

16

Small-scale

0.624

High

818720

SIX1
Homeobox protein SIX1

2

20

Small-scale

0.624

High

818710

SIN3A
Paired amphipathic helix protein Sin3a

2

8

Small-scale

0.621

High

222668

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

19

High-throughput

0.618

High

818698

CTNB1
Catenin beta-1

1

19

Small-scale

0.618

High

818696

TYY1
Transcriptional repressor protein YY1

2

13

Small-scale

0.595

High

818716

ERR2
Steroid hormone receptor ERR2

2

20

Small-scale

0.595

High

818727

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

20

Small-scale

0.594

High

818688

HDAC2
Histone deacetylase 2

2

20

Small-scale

0.588

High

818722

TFE3
Transcription factor E3

2

16

High-throughput

0.584

High

818742

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

2

6

Small-scale

0.584

High

818753

Q921K2
Poly [ADP-ribose] polymerase

2

20

Small-scale

0.584

High

818693

CBX1
Chromobox protein homolog 1

1

16

High-throughput

0.561

High

818718

CBX5
Chromobox protein homolog 5

1

16

High-throughput

0.561

High

818771

Q9DCC5
Cbx3 protein

1

16

High-throughput

0.561

High

818773

XPO4
Exportin-4

1

10

Small-scale

0.561

High

818775

Q9QX99
T-cell leukemia, homeobox 1

1

20

Small-scale

0.561

High

192289

ALX4
Homeobox protein aristaless-like 4

1

20

High-throughput

0.541

High

818684

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.541

High

818692

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.541

High

682100

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.501

High

703482

STF1
Steroidogenic factor 1

1

19

Small-scale

0.501

High

818686

UBC9
SUMO-conjugating enzyme UBC9

1

9

Small-scale

0.501

High

818702

SMCA4
Transcription activator BRG1

1

20

Small-scale

0.501

High

818723

DLX1
Homeobox protein DLX-1

1

20

Small-scale

0.501

High

56789

CUL4B
Cullin-4B

1

13

Small-scale

0.479

High

57760

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

193430

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

16

High-throughput

0.479

High

291907

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

11

High-throughput

0.479

High

399084

TBA1B
Tubulin alpha-1B chain

1

4

High-throughput

0.479

High

539724

LMNB1
Lamin-B1

1

17

High-throughput

0.479

High

541443

RLA0
Large ribosomal subunit protein uL10

1

6

High-throughput

0.479

High

588706

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

589617

VIME
Vimentin

1

5

High-throughput

0.479

High

617176

XRCC6
X-ray repair cross-complementing protein 6

1

9

High-throughput

0.479

High

620784

PCGF2
Polycomb group RING finger protein 2

1

20

High-throughput

0.479

High

725345

RFC1
Replication factor C subunit 1

1

14

High-throughput

0.479

High

794347

MSH2
DNA mismatch repair protein Msh2

1

3

High-throughput

0.479

High

818677

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

4

High-throughput

0.479

High

818678

MSH6
DNA mismatch repair protein Msh6

1

7

High-throughput

0.479

High

818680

RUVB1
RuvB-like 1

1

7

High-throughput

0.479

High

818681

MGN
Protein mago nashi homolog

1

3

High-throughput

0.479

High

818682

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.479

High

818683

H4
Histone H4

1

8

High-throughput

0.479

High

818685

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

818687

TBB4B
Tubulin beta-4B chain

1

3

High-throughput

0.479

High

818689

TBX3
T-box transcription factor TBX3

1

16

High-throughput

0.479

High

818690

ELAV1
ELAV-like protein 1

1

3

High-throughput

0.479

High

818691

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

9

High-throughput

0.479

High

818694

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

High-throughput

0.479

High

818697

CREB1
Cyclic AMP-responsive element-binding protein 1

1

7

High-throughput

0.479

High

818700

CUL4A
Cullin-4A

1

13

Small-scale

0.479

High

818701

Q3TIX6
Far upstream element

1

20

High-throughput

0.479

High

818703

FUBP2
Far upstream element-binding protein 2

1

20

High-throughput

0.479

High

818704

Q3U0X6
Zinc finger protein 217

1

5

High-throughput

0.479

High

818705

DDB1
DNA damage-binding protein 1

1

6

Small-scale

0.479

High

818706

KIF22
Kinesin-like protein KIF22

1

2

High-throughput

0.479

High

818707

DDX17
Probable ATP-dependent RNA helicase DDX17

1

12

High-throughput

0.479

High

818709

Q5SUH6
Clathrin interactor 1

1

6

High-throughput

0.479

High

818711

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

11

High-throughput

0.479

High

818712

RBBP4
Histone-binding protein RBBP4

1

20

High-throughput

0.479

High

818713

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

818714

LAP2B
Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma

1

6

High-throughput

0.479

High

818715

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

8

High-throughput

0.479

High

818717

HIRA
Protein HIRA

1

20

High-throughput

0.479

High

818719

RBM38
RNA-binding protein 38

1

11

High-throughput

0.479

High

818721

TIF1B
Transcription intermediary factor 1-beta

1

20

High-throughput

0.479

High

818725

Q6P5E3
Sal-like 1

1

18

High-throughput

0.479

High

818726

SRSF1
Serine/arginine-rich splicing factor 1

1

16

High-throughput

0.479

High

818728

NUP98
Nuclear pore complex protein Nup98-Nup96

1

4

High-throughput

0.479

High

818729

DCAF5
DDB1- and CUL4-associated factor 5

1

20

Small-scale

0.479

High

818730

PUM2
Pumilio homolog 2

1

1

High-throughput

0.479

High

818731

UBN2
Ubinuclein-2

1

20

High-throughput

0.479

High

818732

KDM5B
Lysine-specific demethylase 5B

1

6

High-throughput

0.479

High

818734

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

9

Small-scale

0.479

High

818735

ARI5B
AT-rich interactive domain-containing protein 5B

1

20

High-throughput

0.479

High

818736

RFOX2
RNA binding protein fox-1 homolog 2

1

11

High-throughput

0.479

High

818737

KAT6B
Histone acetyltransferase KAT6B

1

20

High-throughput

0.479

High

818738

Q8BTS0
Probable ATP-dependent RNA helicase DDX5

1

12

High-throughput

0.479

High

818740

TREF1
Transcriptional-regulating factor 1

1

20

High-throughput

0.479

High

818741

RCOR2
REST corepressor 2

1

20

Small-scale

0.479

High

818743

MATR3
Matrin-3

1

15

High-throughput

0.479

High

818744

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

18

High-throughput

0.479

High

818745

RFC3
Replication factor C subunit 3

1

11

High-throughput

0.479

High

818746

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

818747

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

20

High-throughput

0.479

High

818748

P66B
Transcriptional repressor p66-beta

1

14

High-throughput

0.479

High

818749

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

11

High-throughput

0.479

High

818750

FUBP1
Far upstream element-binding protein 1

1

20

High-throughput

0.479

High

818751

SP16H
FACT complex subunit SPT16

1

7

High-throughput

0.479

High

818752

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

818754

GLYR1
Cytokine-like nuclear factor N-PAC

1

12

High-throughput

0.479

High

818757

PRP19
Pre-mRNA-processing factor 19

1

20

High-throughput

0.479

High

818759

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

3

High-throughput

0.479

High

818760

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

High-throughput

0.479

High

818761

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

818762

SMC1A
Structural maintenance of chromosomes protein 1A

1

7

High-throughput

0.479

High

818763

SMC3
Structural maintenance of chromosomes protein 3

1

6

High-throughput

0.479

High

818764

RBM8A
RNA-binding protein 8A

1

11

High-throughput

0.479

High

818765

RL11
Large ribosomal subunit protein uL5

1

3

High-throughput

0.479

High

818766

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

6

High-throughput

0.479

High

818767

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

6

High-throughput

0.479

High

818768

ING5
Inhibitor of growth protein 5

1

9

High-throughput

0.479

High

818769

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

8

Small-scale

0.479

High

818770

AKAP8
A-kinase anchor protein 8

1

6

High-throughput

0.479

High

818772

RBP2
E3 SUMO-protein ligase RanBP2

1

9

High-throughput

0.479

High

818774

DAZP1
DAZ-associated protein 1

1

12

High-throughput

0.479

High

818776

TFEB
Transcription factor EB

1

8

High-throughput

0.479

High

818777

RUVB2
RuvB-like 2

1

7

High-throughput

0.479

High

818778

KLF5
Krueppel-like factor 5

1

20

High-throughput

0.479

High

818779

ILF3
Interleukin enhancer-binding factor 3

1

20

High-throughput

0.479

High

818780

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

14

High-throughput

0.479

High

818781

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

14

High-throughput

0.479

High

818679

RD23B
UV excision repair protein RAD23 homolog B

1

3

Small-scale

0.445

High

82750

B9EKJ1
Spna2 protein

1

10

High-throughput

0.437

High

818708

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

High-throughput

0.437

High

818724

NOP58
Nucleolar protein 58

1

7

High-throughput

0.437

High

818755

ATAD3
ATPase family AAA domain-containing protein 3

1

7

High-throughput

0.437

High

818756

Q99JL6
Ribosomal protein

1

4

High-throughput

0.437

High

506785

FINC
Fibronectin

1

0

High-throughput

0.249

Low

818699

RCN1
Reticulocalbin-1

1

0

High-throughput

0.249

Low

818758

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024