Protein: MED18
Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) (dp28b)

Gene: MED18
Organism: Drosophila melanogaster
Interactions: 66
UniProt ID: Q9XZT1

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex
GO:0060261 - positive regulation of transcription initiation by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1019312

MED20
Mediator of RNA polymerase II transcription subunit 20

5

1

High-throughput

0.912

High

58525

MED8
Mediator of RNA polymerase II transcription subunit 8

2

1

High-throughput

0.737

High

1487445

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.737

High

1465345

MED22
Mediator of RNA polymerase II transcription subunit 22

1

1

High-throughput

0.575

High

1267083

MED29
Mediator of RNA polymerase II transcription subunit 29

2

1

High-throughput

0.571

High

1269651

MED13
Mediator of RNA polymerase II transcription subunit 13

2

2

High-throughput

0.571

High

1302907

MED31
Mediator of RNA polymerase II transcription subunit 31

2

1

High-throughput

0.571

High

1321595

MED6
Mediator of RNA polymerase II transcription subunit 6

2

2

High-throughput

0.571

High

1428015

MED10
Mediator of RNA polymerase II transcription subunit 10

2

1

High-throughput

0.571

High

1428122

MED7
Mediator of RNA polymerase II transcription subunit 7

2

1

High-throughput

0.571

High

1472626

MED17
Mediator of RNA polymerase II transcription subunit 17

2

1

High-throughput

0.571

High

1473461

Q9VF03
Brahma associated protein 155 kDa

2

2

High-throughput

0.571

High

1482752

MED27
Mediator of RNA polymerase II transcription subunit 27

2

1

High-throughput

0.571

High

1485357

MED4
Mediator of RNA polymerase II transcription subunit 4

2

1

High-throughput

0.571

High

1485625

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

1

High-throughput

0.571

High

1485971

CDK8
Cyclin-dependent kinase 8

2

3

High-throughput

0.571

High

1488721

BAP60
Brahma-associated protein of 60 kDa

2

1

High-throughput

0.571

High

1489435

MED30
Mediator of RNA polymerase II transcription subunit 30

2

1

High-throughput

0.571

High

1489444

MED14
Mediator of RNA polymerase II transcription subunit 14

2

1

High-throughput

0.571

High

1489653

MED23
Mediator of RNA polymerase II transcription subunit 23

2

1

High-throughput

0.571

High

1489730

MED16
Mediator of RNA polymerase II transcription subunit 16

2

1

High-throughput

0.571

High

1490402

MED15
Mediator of RNA polymerase II transcription subunit 15

2

1

High-throughput

0.571

High

674073

BRM
ATP-dependent helicase brm

2

0

High-throughput

0.547

High

900694

DSH
Segment polarity protein dishevelled

2

0

High-throughput

0.547

High

1171950

Q24090
GH08712p

2

0

High-throughput

0.547

High

1261449

Q7JQT8
LD41464p

2

0

High-throughput

0.547

High

1263913

Q7K012
Brahma associated protein 55kD

2

0

High-throughput

0.547

High

1303646

OSA
Trithorax group protein osa

2

0

High-throughput

0.547

High

1377822

EBI
F-box-like/WD repeat-containing protein ebi

2

0

High-throughput

0.547

High

1472599

Q9VEB9
Sequence-specific single-stranded DNA-binding protein, isoform A

2

0

High-throughput

0.547

High

1480285

Q9VL29
GEO11246p1

2

0

High-throughput

0.547

High

53618

A1Z813
Secretory 24AB, isoform A

2

1

High-throughput

0.521

High

57007

A1ZAK9
P-element somatic inhibitor, isoform A

1

1

High-throughput

0.479

High

1484631

Q9VR42
Serine/threonine-protein kinase RIO3

1

0

High-throughput

0.458

High

56967

A1ZAK7
LD35640p

1

1

High-throughput

0.445

High

1471853

MED25
Mediator of RNA polymerase II transcription subunit 25

1

1

High-throughput

0.445

High

1485583

MED24
Mediator of RNA polymerase II transcription subunit 24

1

1

High-throughput

0.445

High

1487356

MED19
Mediator of RNA polymerase II transcription subunit 19

1

1

High-throughput

0.445

High

1487594

MED12
Mediator of RNA polymerase II transcription subunit 12

1

2

High-throughput

0.445

High

1485840

Q9VSY2
Cleavage and polyadenylation specificity factor subunit 5

1

1

High-throughput

0.437

High

85002

B7Z126
non-specific serine/threonine protein kinase

1

0

High-throughput

0.426

High

197502

O18353
CHIP

1

0

High-throughput

0.426

High

1306470

INDRA
Zinc finger protein indra

1

0

High-throughput

0.426

High

1322109

Q8MZI3
RNA helicase

1

0

High-throughput

0.426

High

1343942

Q8SXP8
TAR DNA-binding protein 43

1

0

High-throughput

0.426

High

1409412

Q9BIW6
Brahma-associated protein 111kD

1

0

High-throughput

0.426

High

1488755

Q9VYK0
Smrter, isoform D

1

0

High-throughput

0.426

High

1489820

Q9W2Y5
YLP motif-containing protein 1

1

0

High-throughput

0.426

High

1489868

Q9W3G1
Uncharacterized protein, isoform A

1

0

High-throughput

0.426

High

1069271

Q0E8G6
Cleavage and polyadenylation specificity factor subunit 5

1

1

High-throughput

0.407

High

1482727

Q9VNF8
Protein transport protein SEC23

1

1

High-throughput

0.407

High

1321540

ENC
Protein encore

2

0

High-throughput

0.298

High

1345942

Q8T4A8
AT07769p

2

0

High-throughput

0.298

High

1346471

MESD
LDLR chaperone boca

2

0

High-throughput

0.298

High

1378968

Q960F7
SD03629p

2

0

High-throughput

0.298

High

1440721

LAR4
La-related protein Larp4B

2

0

High-throughput

0.298

High

1486613

Q9VUB7
PAX-interacting protein 1

2

0

High-throughput

0.298

High

1489403

Q9W0L7
ubiquitinyl hydrolase 1

2

0

High-throughput

0.298

High

1482425

Q9VN89
Katanin p60 ATPase-containing subunit A1

1

0

High-throughput

0.265

Low

1488892

Q9VYZ8
GEO08286p1

1

0

High-throughput

0.249

Low

84739

UNR
RNA-binding protein Unr

1

0

High-throughput

0.232

Low

1069951

Q0E996
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.232

Low

1346043

ENA
Protein enabled

1

0

High-throughput

0.232

Low

1378349

Q95TT5
LD24616p

1

0

High-throughput

0.232

Low

1484635

Q9VR43
AT09986p

1

0

High-throughput

0.232

Low

1489846

FRDA
Frataxin homolog, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025