Protein: MED8
Mediator of RNA polymerase II transcription subunit 8 (Mediator complex subunit 8)

Gene: MED8
Organism: Drosophila melanogaster
Interactions: 75
UniProt ID: A1ZBT5

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003712 - transcription coregulator activity
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex
GO:0070847 - core mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

58476

MED6
Mediator of RNA polymerase II transcription subunit 6

2

1

High-throughput

0.737

High

58486

MED7
Mediator of RNA polymerase II transcription subunit 7

2

1

High-throughput

0.737

High

58514

MED11
Mediator of RNA polymerase II transcription subunit 11

2

2

High-throughput

0.737

High

58525

MED18
Mediator of RNA polymerase II transcription subunit 18

2

1

High-throughput

0.737

High

58470

MED29
Mediator of RNA polymerase II transcription subunit 29

3

1

High-throughput

0.629

High

58473

MED31
Mediator of RNA polymerase II transcription subunit 31

1

1

High-throughput

0.575

High

58489

MED22
Mediator of RNA polymerase II transcription subunit 22

1

1

High-throughput

0.575

High

58471

MED13
Mediator of RNA polymerase II transcription subunit 13

2

2

High-throughput

0.571

High

58481

EBI
F-box-like/WD repeat-containing protein ebi

2

1

High-throughput

0.571

High

58485

MED10
Mediator of RNA polymerase II transcription subunit 10

2

1

High-throughput

0.571

High

58496

MED17
Mediator of RNA polymerase II transcription subunit 17

2

1

High-throughput

0.571

High

58497

Q9VF03
Brahma associated protein 155 kDa

2

2

High-throughput

0.571

High

58502

MED27
Mediator of RNA polymerase II transcription subunit 27

2

1

High-throughput

0.571

High

58507

MED4
Mediator of RNA polymerase II transcription subunit 4

2

1

High-throughput

0.571

High

58511

CDK8
Cyclin-dependent kinase 8

2

3

High-throughput

0.571

High

58517

BAP60
Brahma-associated protein of 60 kDa

2

1

High-throughput

0.571

High

58519

MED30
Mediator of RNA polymerase II transcription subunit 30

2

2

High-throughput

0.571

High

58520

MED14
Mediator of RNA polymerase II transcription subunit 14

2

1

High-throughput

0.571

High

58521

MED23
Mediator of RNA polymerase II transcription subunit 23

2

1

High-throughput

0.571

High

58522

MED16
Mediator of RNA polymerase II transcription subunit 16

2

1

High-throughput

0.571

High

58460

BRM
ATP-dependent helicase brm

2

0

High-throughput

0.547

High

58465

Q24090
GH08712p

2

0

High-throughput

0.547

High

58466

Q7JQT8
LD41464p

2

0

High-throughput

0.547

High

58493

MED25
Mediator of RNA polymerase II transcription subunit 25

2

0

High-throughput

0.547

High

58501

Q9VNF8
Protein transport protein SEC23

2

1

High-throughput

0.521

High

58509

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

1

High-throughput

0.521

High

58512

Q9VUB7
PAX-interacting protein 1

2

1

High-throughput

0.521

High

58459

DORS
Embryonic polarity protein dorsal

1

0

High-throughput

0.486

High

58526

MED15
Mediator of RNA polymerase II transcription subunit 15

1

1

High-throughput

0.479

High

54826

A1Z904
Dystrobrevin

1

3

High-throughput

0.451

High

58462

MED20
Mediator of RNA polymerase II transcription subunit 20

1

2

High-throughput

0.445

High

58492

MED28
Mediator of RNA polymerase II transcription subunit 28

1

1

High-throughput

0.445

High

58503

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

High-throughput

0.445

High

58508

MED24
Mediator of RNA polymerase II transcription subunit 24

1

1

High-throughput

0.445

High

58513

MED19
Mediator of RNA polymerase II transcription subunit 19

1

2

High-throughput

0.445

High

58515

MED12
Mediator of RNA polymerase II transcription subunit 12

1

2

High-throughput

0.445

High

58464

Q0E9B2
Dystrobrevin

1

3

High-throughput

0.439

High

58472

DMDE
Dystrophin, isoform E

1

3

High-throughput

0.439

High

56969

A1ZAK9
P-element somatic inhibitor, isoform A

1

1

High-throughput

0.437

High

58458

O18353
CHIP

1

0

High-throughput

0.426

High

58469

Q7K012
Brahma associated protein 55kD

1

0

High-throughput

0.426

High

58474

OSA
Trithorax group protein osa

1

0

High-throughput

0.426

High

58467

Q7JWD6
Elongin-C

1

1

High-throughput

0.417

High

58494

DMDA
Dystrophin, isoforms A/C/F/G/H

1

3

High-throughput

0.417

High

53546

A1Z813
Secretory 24AB, isoform A

1

1

High-throughput

0.407

High

56925

A1ZAK7
LD35640p

1

1

High-throughput

0.407

High

58504

TR112
Multifunctional methyltransferase subunit TRM112-like protein

3

0

High-throughput

0.340

High

58488

VPS28
Vacuolar protein sorting-associated protein 28 homolog

2

0

High-throughput

0.310

High

58491

Q9VAY6
Pre-mRNA-splicing factor SPF27

2

0

High-throughput

0.310

High

58461

DSH
Segment polarity protein dishevelled

2

0

High-throughput

0.298

High

58480

MESD
LDLR chaperone boca

2

0

High-throughput

0.298

High

58483

Q960F7
SD03629p

2

0

High-throughput

0.298

High

58487

LAR4
La-related protein Larp4B

2

0

High-throughput

0.298

High

58500

Q9VL29
GEO11246p1

2

0

High-throughput

0.298

High

58518

Q9W0L7
ubiquitinyl hydrolase 1

2

0

High-throughput

0.298

High

58478

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.265

Low

58490

Q9VA10
FI21270p1

1

0

High-throughput

0.265

Low

58498

Q9VG03
GH08448p

1

0

High-throughput

0.265

Low

58510

Q9VSZ1
GH05942p

1

0

High-throughput

0.265

Low

58505

Q9VR42
Serine/threonine-protein kinase RIO3

1

0

High-throughput

0.249

Low

58499

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.238

Low

58456

B7Z126
non-specific serine/threonine protein kinase

1

0

High-throughput

0.232

Low

58457

H33A
Histone H3.3A

1

0

High-throughput

0.232

Low

58463

Q0E996
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.232

Low

58468

Q7JWU9
AT07420p

1

0

High-throughput

0.232

Low

58475

ENC
Protein encore

1

0

High-throughput

0.232

Low

58477

Q8SXP8
TAR DNA-binding protein 43

1

0

High-throughput

0.232

Low

58479

Q8T485
AT10995p

1

0

High-throughput

0.232

Low

58482

Q95TT5
LD24616p

1

0

High-throughput

0.232

Low

58484

Q9BIW6
Brahma-associated protein 111kD

1

0

High-throughput

0.232

Low

58495

Q9VEB9
Sequence-specific single-stranded DNA-binding protein, isoform A

1

0

High-throughput

0.232

Low

58506

Q9VR43
AT09986p

1

0

High-throughput

0.232

Low

58516

Q9VXZ3
Ben, isoform C

1

0

High-throughput

0.232

Low

58523

Q9W2Y5
YLP motif-containing protein 1

1

0

High-throughput

0.232

Low

58524

Q9W3G1
Uncharacterized protein, isoform A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025