Protein: SGPL1
Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase)

Gene: SGPL1
Organism: Homo sapiens
Interactions: 190
UniProt ID: O95470

Gene Ontology (top 5):
GO:0001553 - luteinization
GO:0001570 - vasculogenesis
GO:0001822 - kidney development
GO:0004068 - aspartate 1-decarboxylase activity
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

315023

TARG1
Trafficking regulator of GLUT4 1

4

1

High-throughput

0.634

High

314937

ESR1
Estrogen receptor

3

5

High-throughput

0.633

High

315039

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

1

High-throughput

0.628

High

314931

EGFR
Epidermal growth factor receptor

2

1

High-throughput

0.611

High

315015

BT2A1
Butyrophilin subfamily 2 member A1

3

2

High-throughput

0.609

High

314982

PLP2
Proteolipid protein 2

2

3

High-throughput

0.606

High

315016

FA2H
Fatty acid 2-hydroxylase

2

1

High-throughput

0.606

High

315012

ANR12
Ankyrin repeat domain-containing protein 12

3

3

High-throughput

0.599

High

315021

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.586

High

226150

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

314955

MIP
Lens fiber major intrinsic protein

2

0

High-throughput

0.580

High

314956

HMOX2
Heme oxygenase 2

2

0

High-throughput

0.580

High

314992

FXYD3
FXYD domain-containing ion transport regulator 3

2

0

High-throughput

0.580

High

315000

SGMR2
Sigma intracellular receptor 2

2

0

High-throughput

0.580

High

315042

B2CL2
Bcl-2-like protein 2

2

0

High-throughput

0.580

High

315076

MARH5
E3 ubiquitin-protein ligase MARCHF5

2

0

High-throughput

0.580

High

315085

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.580

High

315089

STX8
Syntaxin-8

2

0

High-throughput

0.580

High

259515

SEM7A
Semaphorin-7A

2

2

High-throughput

0.574

High

314929

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

3

High-throughput

0.574

High

314958

CADH5
Cadherin-5

2

2

High-throughput

0.574

High

315062

TRIM9
E3 ubiquitin-protein ligase TRIM9

2

6

High-throughput

0.574

High

315081

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

2

High-throughput

0.574

High

314973

RHOA
Transforming protein RhoA

2

1

High-throughput

0.571

High

156128

TSN4
Tetraspanin-4

2

1

High-throughput

0.553

High

201079

AQP9
Aquaporin-9

2

2

High-throughput

0.553

High

315013

MFSD6
Major facilitator superfamily domain-containing protein 6

2

1

High-throughput

0.553

High

315034

SCAM5
Secretory carrier-associated membrane protein 5

2

1

High-throughput

0.553

High

315040

AQP3
Aquaporin-3

2

1

High-throughput

0.553

High

196709

CYB5B
Cytochrome b5 type B

1

1

High-throughput

0.536

High

314949

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.536

High

314952

CALX
Calnexin

1

1

High-throughput

0.536

High

314960

APJ
Apelin receptor

1

1

High-throughput

0.536

High

314961

BASI
Basigin

1

1

High-throughput

0.536

High

315046

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.536

High

315066

CSTN2
Calsyntenin-2

1

3

High-throughput

0.536

High

315069

CHODL
Chondrolectin

1

2

High-throughput

0.536

High

315096

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

314986

PTK6
Protein-tyrosine kinase 6

2

5

High-throughput

0.521

High

314930

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.513

High

314944

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.513

High

314950

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

314988

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

315001

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

315006

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.513

High

315045

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

315056

MBOA7
Lysophospholipid acyltransferase 7

1

0

High-throughput

0.513

High

315059

SEC62
Translocation protein SEC62

1

0

High-throughput

0.513

High

315064

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

119058

LEG9
Galectin-9

1

1

High-throughput

0.489

High

155872

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

1

High-throughput

0.489

High

171914

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.489

High

314934

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

2

High-throughput

0.489

High

314945

CADH1
Cadherin-1

1

4

High-throughput

0.489

High

314972

CXCR4
C-X-C chemokine receptor type 4

1

1

High-throughput

0.489

High

314974

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.489

High

314980

IDD
Integral membrane protein DGCR2/IDD

1

1

High-throughput

0.489

High

314984

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.489

High

314989

RBM39
RNA-binding protein 39

1

3

High-throughput

0.489

High

314994

P2RY6
P2Y purinoceptor 6

1

3

High-throughput

0.489

High

314995

PKN2
Serine/threonine-protein kinase N2

1

4

High-throughput

0.489

High

314996

DDB1
DNA damage-binding protein 1

1

2

High-throughput

0.489

High

315019

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

1

High-throughput

0.489

High

315020

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

1

1

High-throughput

0.489

High

315087

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.489

High

315094

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

315095

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

155230

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

163703

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

314946

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.479

High

315018

CNTRL
Centriolin

1

4

High-throughput

0.479

High

315031

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

315058

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

315061

DERL1
Derlin-1

1

2

High-throughput

0.479

High

61004

A5PKU2
TUSC5 protein

1

1

High-throughput

0.470

High

314962

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

314971

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

315044

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

315054

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

314979

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.457

High

314998

DDR2
Discoidin domain-containing receptor 2

1

7

High-throughput

0.457

High

150797

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

4

High-throughput

0.437

High

160305

AURKA
Aurora kinase A

1

5

High-throughput

0.437

High

314928

ERR2
Steroid hormone receptor ERR2

1

4

High-throughput

0.437

High

314933

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

314935

HBD
Hemoglobin subunit delta

1

1

High-throughput

0.437

High

314940

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

314943

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.437

High

314948

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

314951

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

314963

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

314968

ATX1
Ataxin-1

1

1

High-throughput

0.437

High

314978

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

315008

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

315009

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

315014

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

315025

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

315041

ESR2
Estrogen receptor beta

1

5

High-throughput

0.437

High

315048

OTUL
Ubiquitin thioesterase otulin

1

1

Small-scale

0.437

High

315051

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

315063

BRD8
Bromodomain-containing protein 8

1

3

High-throughput

0.437

High

315067

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

315071

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.437

High

315074

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

315078

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.437

High

315082

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

315088

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.437

High

275357

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

315004

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

99533

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

314939

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.407

High

314941

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

314977

HBB
Hemoglobin subunit beta

1

1

High-throughput

0.407

High

315010

Q6PG48
ANKRD12 protein

1

1

High-throughput

0.407

High

146309

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

0

High-throughput

0.347

High

315091

VSIG4
V-set and immunoglobulin domain-containing protein 4

3

0

High-throughput

0.347

High

314966

P2RX1
P2X purinoceptor 1

2

0

High-throughput

0.328

High

314985

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

High-throughput

0.328

High

314990

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.328

High

315068

PACC1
Proton-activated chloride channel

2

0

High-throughput

0.328

High

314936

STAT
Statherin

2

0

High-throughput

0.316

High

314967

EFNA5
Ephrin-A5

2

0

High-throughput

0.316

High

314981

IFM3
Interferon-induced transmembrane protein 3

2

0

High-throughput

0.316

High

314983

STX4
Syntaxin-4

2

0

High-throughput

0.316

High

314999

UNC50
Protein unc-50 homolog

2

0

High-throughput

0.316

High

315002

RNS10
Inactive ribonuclease-like protein 10

2

0

High-throughput

0.316

High

315003

RTP2
Receptor-transporting protein 2

2

0

High-throughput

0.316

High

315007

PLPP4
Phospholipid phosphatase 4

2

0

High-throughput

0.316

High

315011

BRID5
BRICHOS domain-containing protein 5

2

0

High-throughput

0.316

High

315026

PAQRA
Monocyte to macrophage differentiation factor 2

2

0

High-throughput

0.316

High

315027

F177A
Protein FAM177A1

2

0

High-throughput

0.316

High

315030

CLD19
Claudin-19

2

0

High-throughput

0.316

High

315033

CC4L
C-C motif chemokine 4-like

2

0

High-throughput

0.316

High

315053

T176A
Transmembrane protein 176A

2

0

High-throughput

0.316

High

315060

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

2

0

High-throughput

0.316

High

315075

TM242
Transmembrane protein 242

2

0

High-throughput

0.316

High

315077

PAQR5
Membrane progestin receptor gamma

2

0

High-throughput

0.316

High

314953

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.298

High

315043

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.298

High

176086

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.279

Low

245297

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

314938

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.279

Low

314942

NPM
Nucleophosmin

1

0

High-throughput

0.279

Low

314947

GPIX
Platelet glycoprotein IX

1

0

High-throughput

0.279

Low

314954

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

314957

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

314964

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

314969

ARSF
Arylsulfatase F

1

0

High-throughput

0.279

Low

314993

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.279

Low

315005

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

315017

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

315022

INLR1
Interferon lambda receptor 1

1

0

High-throughput

0.279

Low

315028

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

315032

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.279

Low

315035

GPBAR
G-protein coupled bile acid receptor 1

1

0

High-throughput

0.279

Low

315037

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

315038

ITLN1
Intelectin-1

1

0

High-throughput

0.279

Low

315047

ARRD3
Arrestin domain-containing protein 3

1

0

High-throughput

0.279

Low

315049

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

315050

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

315052

CREL1
Protein disulfide isomerase CRELD1

1

0

High-throughput

0.279

Low

315057

OPALI
Opalin

1

0

High-throughput

0.279

Low

315065

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

315080

MO4L1
Mortality factor 4-like protein 1

1

0

High-throughput

0.279

Low

315083

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

315084

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

315086

NP1L2
Nucleosome assembly protein 1-like 2

1

0

High-throughput

0.279

Low

315090

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

0

High-throughput

0.279

Low

315092

NGN3
Neurogenin-3

1

0

High-throughput

0.279

Low

315093

PCDB3
Protocadherin beta-3

1

0

High-throughput

0.279

Low

314991

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.269

Low

122426

MEN1
Menin

1

0

High-throughput

0.249

Low

125068

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.249

Low

204877

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

314932

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

314959

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

314965

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.249

Low

314970

TPTE
Putative tyrosine-protein phosphatase TPTE

1

0

High-throughput

0.249

Low

314975

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

314976

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.249

Low

314997

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

315024

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

315036

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

315055

TXD15
Thioredoxin domain-containing protein 15

1

0

High-throughput

0.249

Low

315070

LFG4
Protein lifeguard 4

1

0

High-throughput

0.249

Low

315072

ANLN
Anillin

1

0

High-throughput

0.249

Low

315073

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

315079

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

314987

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low

315029

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024