Protein: KLK5
Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme)

Gene: KLK5
Organism: Homo sapiens
Interactions: 110
UniProt ID: Q9Y337

Gene Ontology (top 5):
GO:0002803 - positive regulation of antibacterial peptide production
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

270350

LRP6
Low-density lipoprotein receptor-related protein 6

2

12

High-throughput

0.811

High

1343118

ISK5
Serine protease inhibitor Kazal-type 5

2

7

Small-scale

0.754

High

1336516

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

2

6

High-throughput

0.705

High

980580

NOTC2
Neurogenic locus notch homolog protein 2

1

15

High-throughput

0.698

High

1085227

PRSS8
Prostasin

1

6

High-throughput

0.691

High

673178

CCND3
G1/S-specific cyclin-D3

3

2

High-throughput

0.667

High

933677

TBA4A
Tubulin alpha-4A chain

3

15

High-throughput

0.667

High

1175268

TBA1A
Tubulin alpha-1A chain

3

15

High-throughput

0.667

High

1236293

EFNMT
eEF1A lysine and N-terminal methyltransferase

3

1

High-throughput

0.667

High

1300888

PASK
PAS domain-containing serine/threonine-protein kinase

3

3

High-throughput

0.667

High

1377525

LOXL2
Lysyl oxidase homolog 2

3

4

High-throughput

0.667

High

506503

ARY2
Arylamine N-acetyltransferase 2

3

0

High-throughput

0.638

High

883449

CF298
Cilia- and flagella-associated protein 298

3

0

High-throughput

0.638

High

365251

FRIH
Ferritin heavy chain

2

3

High-throughput

0.628

High

546643

ARSA
Arylsulfatase A

2

8

High-throughput

0.628

High

258362

LRP5
Low-density lipoprotein receptor-related protein 5

1

11

High-throughput

0.618

High

351117

LDLR
Low-density lipoprotein receptor

1

12

High-throughput

0.618

High

1285313

SO4A1
Solute carrier organic anion transporter family member 4A1

1

2

High-throughput

0.618

High

381331

TBB4A
Tubulin beta-4A chain

2

13

High-throughput

0.611

High

59847

DEN11
DENN domain-containing protein 11

3

2

High-throughput

0.609

High

225688

PCDH7
Protocadherin-7

3

10

High-throughput

0.609

High

371115

NU1M
NADH-ubiquinone oxidoreductase chain 1

3

1

High-throughput

0.609

High

574587

ITB5
Integrin beta-5

3

4

High-throughput

0.609

High

880369

DPOE2
DNA polymerase epsilon subunit 2

3

1

High-throughput

0.609

High

1037451

TBB3
Tubulin beta-3 chain

3

13

High-throughput

0.609

High

1114269

TBB8
Tubulin beta-8 chain

3

13

High-throughput

0.609

High

1204970

FRAS1
Extracellular matrix organizing protein FRAS1

3

20

High-throughput

0.609

High

1310652

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

3

5

High-throughput

0.609

High

1377526

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

3

1

High-throughput

0.609

High

1229690

FCSK
L-fucose kinase

2

0

High-throughput

0.585

High

1306639

CPNE1
Copine-1

2

0

High-throughput

0.585

High

1347896

MKS1
Tectonic-like complex member MKS1

2

0

High-throughput

0.585

High

1034566

OS9
Protein OS-9

2

3

High-throughput

0.558

High

1133347

GT253
Inactive glycosyltransferase 25 family member 3

2

2

High-throughput

0.558

High

1267502

AP3S1
AP-3 complex subunit sigma-1

2

1

High-throughput

0.558

High

1355966

MCM8
DNA helicase MCM8

2

1

High-throughput

0.558

High

1357834

NEUR3
Sialidase-3

2

2

High-throughput

0.558

High

160870

AURKA
Aurora kinase A

1

1

High-throughput

0.541

High

314177

BAG4
BAG family molecular chaperone regulator 4

1

3

High-throughput

0.541

High

351479

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

9

High-throughput

0.541

High

370770

ESR1
Estrogen receptor

1

7

High-throughput

0.541

High

384043

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

14

High-throughput

0.541

High

1059402

CASP8
Caspase-8

1

4

High-throughput

0.541

High

1306619

TS101
Tumor susceptibility gene 101 protein

1

1

High-throughput

0.541

High

301245

RHBT3
Rho-related BTB domain-containing protein 3

1

3

High-throughput

0.536

High

313160

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

1

1

High-throughput

0.536

High

344810

TIMP1
Metalloproteinase inhibitor 1

1

2

High-throughput

0.536

High

428515

TBB5
Tubulin beta chain

1

13

High-throughput

0.536

High

502706

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.536

High

676776

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

2

High-throughput

0.536

High

713422

BMP8B
Bone morphogenetic protein 8B

1

9

High-throughput

0.536

High

805495

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

4

High-throughput

0.536

High

827665

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.536

High

934035

TBB4B
Tubulin beta-4B chain

1

13

High-throughput

0.536

High

1040781

PEX6
Peroxisomal ATPase PEX6

1

1

High-throughput

0.536

High

1069197

PON2
Serum paraoxonase/arylesterase 2

1

4

High-throughput

0.536

High

1294410

SYNM
Asparaginyl-tRNA synthetase

1

2

High-throughput

0.536

High

1343435

TSSP
Thymus-specific serine protease

1

2

High-throughput

0.536

High

1356252

FBX2
F-box only protein 2

1

2

High-throughput

0.536

High

960678

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.513

High

1202310

TRXR3
Thioredoxin reductase 3

1

0

High-throughput

0.513

High

1252021

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

0

High-throughput

0.513

High

1273376

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

1

0

High-throughput

0.513

High

1300052

TPPC9
Trafficking protein particle complex subunit 9

1

0

High-throughput

0.513

High

596336

FILA
Filaggrin

1

9

Small-scale

0.501

High

836622

CAMP
Cathelicidin antimicrobial peptide

1

2

Small-scale

0.501

High

435809

IGF1R
Insulin-like growth factor 1 receptor

1

15

High-throughput

0.494

High

531010

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

6

High-throughput

0.489

High

1034817

TMED1
Transmembrane emp24 domain-containing protein 1

1

3

High-throughput

0.489

High

1046624

TBB2A
Tubulin beta-2A chain

1

13

High-throughput

0.489

High

1069993

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

8

High-throughput

0.489

High

1115437

FUT11
Alpha-(1,3)-fucosyltransferase 11

1

2

High-throughput

0.489

High

1128139

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

5

High-throughput

0.489

High

1139011

GP107
Protein GPR107

1

3

High-throughput

0.489

High

1152281

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

3

High-throughput

0.489

High

1154119

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

15

High-throughput

0.489

High

1159585

TTC27
Tetratricopeptide repeat protein 27

1

4

High-throughput

0.489

High

1162578

TXD11
Thioredoxin domain-containing protein 11

1

8

High-throughput

0.489

High

1199308

OAF
Out at first protein homolog

1

1

High-throughput

0.489

High

1216307

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

5

High-throughput

0.489

High

1220711

MIRO2
Mitochondrial Rho GTPase 2

1

8

High-throughput

0.489

High

1220737

MIRO1
Mitochondrial Rho GTPase 1

1

8

High-throughput

0.489

High

1262017

ZDH19
Palmitoyltransferase ZDHHC19

1

2

High-throughput

0.489

High

1266816

TM9S4
Transmembrane 9 superfamily member 4

1

8

High-throughput

0.489

High

1288849

ERLEC
Endoplasmic reticulum lectin 1

1

3

High-throughput

0.489

High

1300418

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.489

High

1309540

TBA1C
Tubulin alpha-1C chain

1

15

High-throughput

0.489

High

1309857

CSTN3
Calsyntenin-3

1

14

High-throughput

0.489

High

1312839

TBB6
Tubulin beta-6 chain

1

13

High-throughput

0.489

High

1354370

SE1L1
Protein sel-1 homolog 1

1

7

High-throughput

0.489

High

1356688

SARDH
Sarcosine dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1357301

DD19B
ATP-dependent RNA helicase DDX19B

1

3

High-throughput

0.489

High

1203243

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

3

High-throughput

0.479

High

513649

PYC
Pyruvate carboxylase, mitochondrial

1

0

High-throughput

0.458

High

1219981

BBS7
Bardet-Biedl syndrome 7 protein

1

0

High-throughput

0.458

High

1229902

TTC5
Tetratricopeptide repeat protein 5

1

0

High-throughput

0.458

High

787703

PI4KA
Phosphatidylinositol 4-kinase alpha

1

5

High-throughput

0.445

High

1117818

Q4LE69
1-phosphatidylinositol 4-kinase

1

5

High-throughput

0.437

High

1132306

FREM2
FRAS1-related extracellular matrix protein 2

1

9

High-throughput

0.437

High

1237711

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

5

High-throughput

0.407

High

1284711

EME1
Crossover junction endonuclease EME1

3

0

High-throughput

0.347

High

1223353

TRM44
Probable tRNA

2

0

High-throughput

0.318

High

1343446

MANBL
Protein MANBAL

2

0

High-throughput

0.316

High

596713

PRPS3
Ribose-phosphate pyrophosphokinase 3

1

0

High-throughput

0.279

Low

1153834

ACD10
Acyl-CoA dehydrogenase family member 10

1

0

High-throughput

0.279

Low

1290002

T3HPD
Trans-3-hydroxy-L-proline dehydratase

1

0

High-throughput

0.279

Low

1315842

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.279

Low

1346596

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.279

Low

1355923

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.279

Low

1302609

INT14
Integrator complex subunit 14

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024