Protein: DLK1
Protein delta homolog 1 (DLK-1) (pG2) [Cleaved into: Fetal antigen 1 (FA1)]

Gene: DLK1
Organism: Homo sapiens
Interactions: 173
UniProt ID: P80370

Gene Ontology (top 5):
GO:0005509 - calcium ion binding
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0016020 - membrane
GO:0030154 - cell differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1010117

EGFL7
Epidermal growth factor-like protein 7

3

19

High-throughput

0.861

High

1010022

NOTC2
Neurogenic locus notch homolog protein 2

2

19

High-throughput

0.776

High

161978

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

4

5

High-throughput

0.691

High

178769

SCAM1
Secretory carrier-associated membrane protein 1

4

2

High-throughput

0.691

High

215998

FIBP
Acidic fibroblast growth factor intracellular-binding protein

4

2

High-throughput

0.691

High

257623

PRAF2
PRA1 family protein 2

4

1

High-throughput

0.691

High

1010066

C2CD5
C2 domain-containing protein 5

4

2

High-throughput

0.691

High

1010072

AN13C
Ankyrin repeat domain-containing protein 13C

4

20

High-throughput

0.691

High

1010107

AT131
Endoplasmic reticulum transmembrane helix translocase

4

5

High-throughput

0.691

High

661256

AT2B4
Plasma membrane calcium-transporting ATPase 4

3

2

High-throughput

0.667

High

1010025

DYH14
Dynein axonemal heavy chain 14

3

4

High-throughput

0.667

High

1010030

AVR2B
Activin receptor type-2B

3

8

High-throughput

0.667

High

1010129

FND3A
Fibronectin type-III domain-containing protein 3A

3

11

High-throughput

0.667

High

207807

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

3

1

High-throughput

0.650

High

256020

S19A2
Thiamine transporter 1

3

0

High-throughput

0.638

High

328812

CSPG5
Chondroitin sulfate proteoglycan 5

3

0

High-throughput

0.638

High

1010042

ANO6
Anoctamin-6

3

0

High-throughput

0.638

High

1010074

LEMD2
LEM domain-containing protein 2

3

0

High-throughput

0.638

High

1010081

DCAKD
Dephospho-CoA kinase domain-containing protein

3

0

High-throughput

0.638

High

1010086

NCLN
BOS complex subunit NCLN

3

0

High-throughput

0.638

High

1010026

TMM94
Transmembrane protein 94

4

1

High-throughput

0.630

High

1010053

MYORG
Myogenesis-regulating glycosidase

4

1

High-throughput

0.630

High

1010060

UBE3B
Ubiquitin-protein ligase E3B

4

17

High-throughput

0.630

High

1010063

LAP4B
Lysosomal-associated transmembrane protein 4B

4

1

High-throughput

0.630

High

1010099

CABL2
CDK5 and ABL1 enzyme substrate 2

4

2

High-throughput

0.630

High

1010115

EVA1B
Protein eva-1 homolog B

2

3

High-throughput

0.628

High

178934

SCAM2
Secretory carrier-associated membrane protein 2

2

2

High-throughput

0.611

High

1010041

TBB8
Tubulin beta-8 chain

2

1

High-throughput

0.611

High

1010070

DEN6A
Protein DENND6A

2

1

High-throughput

0.611

High

1010092

ANR27
Ankyrin repeat domain-containing protein 27

2

8

High-throughput

0.611

High

65341

TCAF2
TRPM8 channel-associated factor 2

3

1

High-throughput

0.609

High

931223

AT12A
Potassium-transporting ATPase alpha chain 2

3

2

High-throughput

0.609

High

1010056

NFRKB
Nuclear factor related to kappa-B-binding protein

3

1

High-throughput

0.609

High

1010079

CABL1
CDK5 and ABL1 enzyme substrate 1

3

2

High-throughput

0.609

High

705307

GRN
Progranulin

2

1

Small-scale

0.606

High

658684

JAK1
Tyrosine-protein kinase JAK1

2

16

High-throughput

0.601

High

933386

S12A2
Solute carrier family 12 member 2

2

5

High-throughput

0.601

High

1010019

AT2C1
Calcium-transporting ATPase type 2C member 1

2

5

High-throughput

0.601

High

1010023

DDR1
Epithelial discoidin domain-containing receptor 1

2

16

High-throughput

0.601

High

1010071

AN13A
Ankyrin repeat domain-containing protein 13A

2

11

High-throughput

0.601

High

1010073

RN149
E3 ubiquitin-protein ligase RNF149

2

4

High-throughput

0.601

High

1010120

LCAP
Leucyl-cystinyl aminopeptidase

2

2

High-throughput

0.601

High

1010035

DIP2A
Disco-interacting protein 2 homolog A

2

0

High-throughput

0.585

High

1010050

STEA3
Metalloreductase STEAP3

2

0

High-throughput

0.585

High

1010130

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

2

0

High-throughput

0.585

High

1010047

ODR4
Protein odr-4 homolog

2

0

High-throughput

0.576

High

582156

INGR1
Interferon gamma receptor 1

1

3

High-throughput

0.575

High

857409

NOTC1
Neurogenic locus notch homolog protein 1

1

19

High-throughput

0.575

High

1010034

GAS6
Growth arrest-specific protein 6

1

20

High-throughput

0.575

High

1010084

SUSD6
Sushi domain-containing protein 6

1

1

High-throughput

0.575

High

1010040

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

2

2

High-throughput

0.558

High

1010043

WDR44
WD repeat-containing protein 44

2

4

High-throughput

0.558

High

1010044

CEP78
Centrosomal protein of 78 kDa

2

2

High-throughput

0.558

High

165566

SCAM3
Secretory carrier-associated membrane protein 3

2

2

High-throughput

0.549

High

522648

PTPRF
Receptor-type tyrosine-protein phosphatase F

2

8

High-throughput

0.549

High

1010036

LAP4A
Lysosomal-associated transmembrane protein 4A

2

1

High-throughput

0.549

High

1010095

OSMR
Oncostatin-M-specific receptor subunit beta

2

11

High-throughput

0.549

High

296349

ATRN
Attractin

1

20

High-throughput

0.536

High

1010039

MICA
MHC class I polypeptide-related sequence A

1

2

High-throughput

0.536

High

1010094

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.536

High

1010122

KDIS
Kinase D-interacting substrate of 220 kDa

1

9

High-throughput

0.536

High

1010127

RUVB2
RuvB-like 2

1

1

High-throughput

0.536

High

1010085

NICA
Nicastrin

1

0

High-throughput

0.513

High

1010093

S38A2
Sodium-coupled neutral amino acid symporter 2

1

0

High-throughput

0.513

High

1010112

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.513

High

231467

ORC4
Origin recognition complex subunit 4

1

1

High-throughput

0.489

High

787286

ACV1B
Activin receptor type-1B

1

8

High-throughput

0.489

High

1010059

ZN627
Zinc finger protein 627

1

19

High-throughput

0.489

High

157232

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

330864

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.479

High

390535

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.479

High

541435

FGFR1
Fibroblast growth factor receptor 1

1

19

High-throughput

0.479

High

565597

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

3

High-throughput

0.479

High

890723

PSN2
Presenilin-2

1

12

High-throughput

0.479

High

1010046

NU188
Nucleoporin NUP188

1

1

High-throughput

0.479

High

1010078

TBC15
TBC1 domain family member 15

1

2

High-throughput

0.479

High

1010061

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

7

High-throughput

0.470

High

932558

GAS1
Growth arrest-specific protein 1

1

0

Small-scale

0.460

High

60713

F234B
Protein FAM234B

1

0

High-throughput

0.458

High

1010052

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.458

High

1010096

ADPGK
ADP-dependent glucokinase

1

0

High-throughput

0.458

High

1010114

INT7
Integrator complex subunit 7

1

0

High-throughput

0.458

High

154567

PLPP3
Phospholipid phosphatase 3

1

3

High-throughput

0.445

High

297344

DYSF
Dysferlin

1

2

High-throughput

0.445

High

299146

FLOT1
Flotillin-1

1

4

High-throughput

0.445

High

361692

F13A
Coagulation factor XIII A chain

1

1

High-throughput

0.445

High

463057

YES
Tyrosine-protein kinase Yes

1

9

High-throughput

0.445

High

484102

PGFRB
Platelet-derived growth factor receptor beta

1

11

High-throughput

0.445

High

505635

ELFN1
Protein ELFN1

1

7

High-throughput

0.445

High

593333

PGFRA
Platelet-derived growth factor receptor alpha

1

13

High-throughput

0.445

High

622583

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

High-throughput

0.445

High

690082

AVR2A
Activin receptor type-2A

1

8

High-throughput

0.445

High

716021

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

1

High-throughput

0.445

High

787146

BMR1A
Bone morphogenetic protein receptor type-1A

1

8

High-throughput

0.445

High

788895

TGFR2
TGF-beta receptor type-2

1

8

High-throughput

0.445

High

828199

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

11

High-throughput

0.445

High

861562

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

17

High-throughput

0.445

High

889966

PSN1
Presenilin-1

1

12

High-throughput

0.445

High

919887

PLK1
Serine/threonine-protein kinase PLK1

1

6

High-throughput

0.445

High

1010021

ATP7A
Copper-transporting ATPase 1

1

2

High-throughput

0.445

High

1010027

SEPR
Prolyl endopeptidase FAP

1

2

High-throughput

0.445

High

1010031

BMPR2
Bone morphogenetic protein receptor type-2

1

12

High-throughput

0.445

High

1010032

DSG2
Desmoglein-2

1

7

High-throughput

0.445

High

1010033

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

1

High-throughput

0.445

High

1010045

PPR29
Protein phosphatase 1 regulatory subunit 29

1

6

High-throughput

0.445

High

1010057

LRRN1
Leucine-rich repeat neuronal protein 1

1

4

High-throughput

0.445

High

1010058

TM1L2
TOM1-like protein 2

1

2

High-throughput

0.445

High

1010068

ZDH13
Palmitoyltransferase ZDHHC13

1

20

High-throughput

0.445

High

1010080

S35F5
Solute carrier family 35 member F5

1

1

High-throughput

0.445

High

1010090

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

17

High-throughput

0.445

High

1010102

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

17

High-throughput

0.445

High

1010103

PCX3
Pecanex-like protein 3

1

5

High-throughput

0.445

High

1010106

KC1G1
Casein kinase I isoform gamma-1

1

4

High-throughput

0.445

High

1010108

IL1AP
Interleukin-1 receptor accessory protein

1

16

High-throughput

0.445

High

1010109

AT132
Polyamine-transporting ATPase 13A2

1

5

High-throughput

0.445

High

1010113

RN19A
E3 ubiquitin-protein ligase RNF19A

1

4

High-throughput

0.445

High

1010119

S12A6
Solute carrier family 12 member 6

1

9

High-throughput

0.445

High

1010121

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

1

High-throughput

0.445

High

1010125

MYO6
Unconventional myosin-VI

1

1

High-throughput

0.445

High

1010126

PCDGK
Protocadherin gamma-C3

1

3

High-throughput

0.445

High

1010131

LRP12
Low-density lipoprotein receptor-related protein 12

1

19

High-throughput

0.445

High

1010132

PCDB2
Protocadherin beta-2

1

3

High-throughput

0.445

High

1010134

KC1G3
Casein kinase I isoform gamma-3

1

5

High-throughput

0.445

High

1010135

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

7

High-throughput

0.445

High

1010069

ZDH17
Palmitoyltransferase ZDHHC17

1

20

High-throughput

0.439

High

779702

MOT8
Monocarboxylate transporter 8

1

6

High-throughput

0.437

High

1010024

GOGA2
Golgin subfamily A member 2

1

3

High-throughput

0.437

High

1010038

OCLN
Occludin

1

3

High-throughput

0.437

High

1010089

P121A
Nuclear envelope pore membrane protein POM 121

1

1

High-throughput

0.437

High

1010104

ZN696
Zinc finger protein 696

1

18

High-throughput

0.437

High

1010124

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.437

High

873385

LSS
Lanosterol synthase

1

0

High-throughput

0.426

High

908002

VAMP7
Vesicle-associated membrane protein 7

1

0

High-throughput

0.426

High

1010020

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.426

High

1010037

SNX17
Sorting nexin-17

1

0

High-throughput

0.426

High

1010049

DAB2P
Disabled homolog 2-interacting protein

1

0

High-throughput

0.426

High

1010064

T200A
Transmembrane protein 200A

1

0

High-throughput

0.426

High

1010067

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.426

High

1010076

TM104
Transmembrane protein 104

1

0

High-throughput

0.426

High

1010082

CANT1
Soluble calcium-activated nucleotidase 1

1

0

High-throughput

0.426

High

163278

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

1

High-throughput

0.407

High

175355

PLXB2
Plexin-B2

1

12

High-throughput

0.407

High

648479

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.407

High

659015

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

9

High-throughput

0.407

High

931937

EPHB4
Ephrin type-B receptor 4

1

9

High-throughput

0.407

High

1010028

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

11

High-throughput

0.407

High

1010029

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

8

High-throughput

0.407

High

1010048

HECD3
E3 ubiquitin-protein ligase HECTD3

1

19

High-throughput

0.407

High

1010077

VANG1
Vang-like protein 1

1

1

High-throughput

0.407

High

1010088

CLIP3
CAP-Gly domain-containing linker protein 3

1

2

High-throughput

0.407

High

1010091

KIRR1
Kin of IRRE-like protein 1

1

18

High-throughput

0.407

High

1010101

RAB34
Ras-related protein Rab-34

1

5

High-throughput

0.407

High

1010111

LRC4B
Leucine-rich repeat-containing protein 4B

1

5

High-throughput

0.407

High

1010123

VANG2
Vang-like protein 2

1

1

High-throughput

0.407

High

1010133

S12A7
Solute carrier family 12 member 7

1

9

High-throughput

0.407

High

1010054

TM214
Transmembrane protein 214

4

0

High-throughput

0.360

High

1010083

BRI3B
BRI3-binding protein

3

0

High-throughput

0.347

High

1010110

OSTC
Oligosaccharyltransferase complex subunit OSTC

3

0

High-throughput

0.347

High

1010051

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

2

0

High-throughput

0.318

High

1010055

M18BP
Mis18-binding protein 1

2

0

High-throughput

0.318

High

1010075

SMG8
Nonsense-mediated mRNA decay factor SMG8

2

0

High-throughput

0.318

High

1010100

SGPP1
Sphingosine-1-phosphate phosphatase 1

2

0

High-throughput

0.318

High

1010105

PGES2
Prostaglandin E synthase 2

2

0

High-throughput

0.318

High

1010118

PCYOX
Prenylcysteine oxidase 1

2

0

High-throughput

0.318

High

1010062

NLRX1
NLR family member X1

1

0

High-throughput

0.249

Low

1010087

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.249

Low

336267

BRI3
Membrane protein BRI3

1

0

High-throughput

0.232

Low

935670

MFAP3
Microfibril-associated glycoprotein 3

1

0

High-throughput

0.232

Low

1010065

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.232

Low

1010097

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.232

Low

1010098

SYT11
Synaptotagmin-11

1

0

High-throughput

0.232

Low

1010116

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.232

Low

1010128

MYRF
Myelin regulatory factor

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025