Protein: GCH1
GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I)

Gene: GCH1
Organism: Homo sapiens
Interactions: 67
UniProt ID: P30793

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0003934 - GTP cyclohydrolase I activity
GO:0005509 - calcium ion binding
GO:0005525 - GTP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

675815

GCH1
GTP cyclohydrolase 1

3

7

Small-scale

0.829

High

670882

GFRP
GTP cyclohydrolase 1 feedback regulatory protein

1

1

Small-scale

0.656

High

675845

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

1

High-throughput

0.628

High

155537

TNPO2
Transportin-2

2

1

High-throughput

0.606

High

675865

TNPO3
Transportin-3

2

1

High-throughput

0.606

High

675822

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.561

High

675835

RBP10
Ran-binding protein 10

1

2

High-throughput

0.536

High

675836

MAEA
E3 ubiquitin-protein transferase MAEA

1

4

High-throughput

0.536

High

675837

ARMC8
Armadillo repeat-containing protein 8

1

1

High-throughput

0.536

High

675848

RANB9
Ran-binding protein 9

1

2

High-throughput

0.536

High

675854

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

3

High-throughput

0.536

High

675859

GID8
Glucose-induced degradation protein 8 homolog

1

4

High-throughput

0.536

High

314239

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.529

High

675831

GIT2
ARF GTPase-activating protein GIT2

1

0

High-throughput

0.518

High

675819

MK12
Mitogen-activated protein kinase 12

1

1

Small-scale

0.515

High

675820

MK10
Mitogen-activated protein kinase 10

1

1

Small-scale

0.515

High

63067

RHG42
Rho GTPase-activating protein 42

1

0

High-throughput

0.513

High

585409

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

High-throughput

0.513

High

621222

RIR1
Ribonucleoside-diphosphate reductase large subunit

1

0

High-throughput

0.513

High

675826

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

High-throughput

0.513

High

675827

RHG01
Rho GTPase-activating protein 1

1

0

High-throughput

0.513

High

675830

SQSTM
Sequestosome-1

1

0

High-throughput

0.513

High

675832

ELOB
Elongin-B

1

0

High-throughput

0.513

High

675833

SIX1
Homeobox protein SIX1

1

0

High-throughput

0.513

High

675839

DEN6A
Protein DENND6A

1

0

High-throughput

0.513

High

675843

DAAF4
Dynein axonemal assembly factor 4

1

0

High-throughput

0.513

High

675846

MOCOS
Molybdenum cofactor sulfurase

1

0

High-throughput

0.513

High

675850

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

0

High-throughput

0.513

High

675853

WDR26
WD repeat-containing protein 26

1

0

High-throughput

0.513

High

675856

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.513

High

675857

EI2BG
Translation initiation factor eIF2B subunit gamma

1

0

High-throughput

0.513

High

675858

BCD1
Box C/D snoRNA protein 1

1

0

High-throughput

0.513

High

675861

DCDC2
Doublecortin domain-containing protein 2

1

0

High-throughput

0.513

High

675866

SNX9
Sorting nexin-9

1

0

High-throughput

0.513

High

631096

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.493

High

675824

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.493

High

675849

OSBL9
Oxysterol-binding protein-related protein 9

1

0

High-throughput

0.493

High

503521

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.486

High

675825

SP3
Transcription factor Sp3

1

0

Small-scale

0.486

High

675828

RLF
Zinc finger protein Rlf

1

0

Small-scale

0.486

High

675834

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.486

High

675847

CNRP1
CB1 cannabinoid receptor-interacting protein 1

1

0

Small-scale

0.486

High

675851

SH3G2
Endophilin-A1

1

0

High-throughput

0.486

High

675863

RAB26
Ras-related protein Rab-26

1

0

Small-scale

0.486

High

533794

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

Small-scale

0.479

High

675816

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

1

Small-scale

0.479

High

675817

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

1

Small-scale

0.479

High

675855

KC1G1
Casein kinase I isoform gamma-1

1

1

Small-scale

0.479

High

675862

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

1

Small-scale

0.479

High

273376

PPM1B
Protein phosphatase 1B

1

0

Small-scale

0.458

High

675818

RGS19
Regulator of G-protein signaling 19

1

0

Small-scale

0.458

High

675821

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

675823

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.458

High

675840

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

0

Small-scale

0.458

High

675841

CALL6
Calmodulin-like protein 6

1

0

Small-scale

0.458

High

675860

CALL5
Calmodulin-like protein 5

1

0

Small-scale

0.458

High

675864

RP3A
Rabphilin-3A

1

0

Small-scale

0.458

High

675844

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

1

High-throughput

0.445

High

675829

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

1

Small-scale

0.437

High

675838

GID4
Glucose-induced degradation protein 4 homolog

1

1

High-throughput

0.437

High

675842

SCTM1
Secreted and transmembrane protein 1

1

1

High-throughput

0.437

High

111366

J3KSN0
Secreted and transmembrane 1

1

1

High-throughput

0.407

High

111613

K7ENE2
GID complex subunit 4 homolog

1

1

High-throughput

0.407

High

129896

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

0

High-throughput

0.279

Low

675852

CABL2
CDK5 and ABL1 enzyme substrate 2

1

0

High-throughput

0.279

Low

393420

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

0

Small-scale

0.251

Low


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Last updated: 15 Jul 2024