Protein: P5CS
Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)]

Gene: P5CS, ALDH18A1
Organism: Homo sapiens
Interactions: 191
UniProt ID: P54886

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004349 - glutamate 5-kinase activity
GO:0004350 - glutamate-5-semialdehyde dehydrogenase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

932843

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

16

High-throughput

0.618

High

897181

CDK7
Cyclin-dependent kinase 7

2

2

High-throughput

0.611

High

371566

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.599

High

241202

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

403937

GCR
Glucocorticoid receptor

2

5

Small-scale

0.584

High

274999

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

2

0

High-throughput

0.580

High

932890

SYDM
Aspartate--tRNA ligase, mitochondrial

2

0

High-throughput

0.580

High

539874

RALB
Ras-related protein Ral-B

2

4

High-throughput

0.574

High

932933

TR61B
tRNA

2

1

High-throughput

0.571

High

345564

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

932862

CUL3
Cullin-3

2

4

High-throughput

0.558

High

932956

ZRAN1
Ubiquitin thioesterase ZRANB1

2

6

High-throughput

0.558

High

932853

KPCZ
Protein kinase C zeta type

1

1

High-throughput

0.536

High

932865

ICT1
Large ribosomal subunit protein mL62

1

3

High-throughput

0.536

High

932876

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.536

High

932904

MYLK4
Myosin light chain kinase family member 4

1

2

High-throughput

0.536

High

932916

CERK1
Ceramide kinase

1

1

High-throughput

0.536

High

932962

TAOK2
Serine/threonine-protein kinase TAO2

1

2

High-throughput

0.536

High

830415

CCNF
Cyclin-F

2

8

High-throughput

0.533

High

932948

ANLN
Anillin

2

2

High-throughput

0.533

High

395756

ESR1
Estrogen receptor

2

5

High-throughput

0.521

High

932854

SOS2
Son of sevenless homolog 2

2

2

High-throughput

0.521

High

932910

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.521

High

932917

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

2

5

High-throughput

0.521

High

932919

ARH40
Rho guanine nucleotide exchange factor 40

2

3

High-throughput

0.521

High

650664

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.513

High

932889

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

932893

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.513

High

932940

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

932959

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

932965

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

127656

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

5

High-throughput

0.489

High

274516

DNJB6
DnaJ homolog subfamily B member 6

1

2

High-throughput

0.489

High

483055

CLCA
Clathrin light chain A

1

3

High-throughput

0.489

High

483315

CLCB
Clathrin light chain B

1

2

High-throughput

0.489

High

932887

L2GL2
LLGL scribble cell polarity complex component 2

1

5

High-throughput

0.489

High

932929

GCP5
Gamma-tubulin complex component 5

1

1

High-throughput

0.489

High

157137

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

279709

CISY
Citrate synthase, mitochondrial

1

3

High-throughput

0.479

High

293427

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

315333

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

400537

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

411650

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.479

High

470944

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.479

High

532480

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

536829

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

547575

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

1

High-throughput

0.479

High

609972

VGFR1
Vascular endothelial growth factor receptor 1

1

6

High-throughput

0.479

High

623211

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

667680

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

786991

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

7

High-throughput

0.479

High

877308

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

3

High-throughput

0.479

High

932844

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.479

High

932847

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

932849

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

932851

VIGLN
Vigilin

1

1

High-throughput

0.479

High

932852

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

932859

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

932863

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.479

High

932871

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

932872

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

932873

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

932877

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

932885

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

932892

KAT3
Kynurenine--oxoglutarate transaminase 3

1

2

High-throughput

0.479

High

932905

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

4

High-throughput

0.479

High

932911

ARL10
ADP-ribosylation factor-like protein 10

1

3

High-throughput

0.479

High

932913

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

932931

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

932952

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

9

Small-scale

0.479

High

932954

WWOX
WW domain-containing oxidoreductase

1

4

High-throughput

0.479

High

932967

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

4

Small-scale

0.479

High

353147

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.470

High

932960

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.470

High

65725

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.458

High

175626

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

High-throughput

0.458

High

413478

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

615506

NELFE
Negative elongation factor E

1

0

High-throughput

0.458

High

760878

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

932856

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.458

High

932866

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

932875

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.458

High

932899

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

932923

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

932950

LATS2
Serine/threonine-protein kinase LATS2

1

0

High-throughput

0.458

High

932957

TES
Testin

1

0

High-throughput

0.458

High

932845

CDC42
Cell division control protein 42 homolog

1

10

High-throughput

0.457

High

429585

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

932850

SUMO1
Small ubiquitin-related modifier 1

1

2

Small-scale

0.445

High

932870

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

1

Small-scale

0.445

High

932883

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

932901

SL9B2
Sodium/hydrogen exchanger 9B2

1

3

High-throughput

0.445

High

932968

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

9

High-throughput

0.445

High

247764

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

319565

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.437

High

324672

HEXI1
Protein HEXIM1

1

1

High-throughput

0.437

High

376772

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

High-throughput

0.437

High

583841

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

3

Small-scale

0.437

High

588304

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

642749

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.437

High

695033

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

767793

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

838924

RHG25
Rho GTPase-activating protein 25

1

3

High-throughput

0.437

High

845260

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

6

High-throughput

0.437

High

932848

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

9

High-throughput

0.437

High

932855

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.437

High

932857

DPYD
Dihydropyrimidine dehydrogenase [NADP(+)]

1

1

High-throughput

0.437

High

932858

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

4

High-throughput

0.437

High

932860

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

High-throughput

0.437

High

932861

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.437

High

932864

TRI14
Tripartite motif-containing protein 14

1

3

High-throughput

0.437

High

932879

SMU1
WD40 repeat-containing protein SMU1

1

7

High-throughput

0.437

High

932880

ANR55
Ankyrin repeat domain-containing protein 55

1

4

High-throughput

0.437

High

932884

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.437

High

932894

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

932897

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

932900

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

932903

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

Small-scale

0.437

High

932908

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.437

High

932909

RHG18
Rho GTPase-activating protein 18

1

3

High-throughput

0.437

High

932915

COP1
E3 ubiquitin-protein ligase COP1

1

9

High-throughput

0.437

High

932918

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.437

High

932920

FBXW7
F-box/WD repeat-containing protein 7

1

7

High-throughput

0.437

High

932924

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.437

High

932927

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

932928

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.437

High

932930

RUFY1
RUN and FYVE domain-containing protein 1

1

3

High-throughput

0.437

High

932934

FACD2
Fanconi anemia group D2 protein

1

8

High-throughput

0.437

High

932935

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

932936

TRI55
Tripartite motif-containing protein 55

1

10

High-throughput

0.437

High

932939

RHG39
Rho GTPase-activating protein 39

1

4

High-throughput

0.437

High

932942

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.437

High

932943

SENP3
Sentrin-specific protease 3

1

1

Small-scale

0.437

High

932944

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

932946

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

932949

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.437

High

932953

TLS1
Splicing factor C9orf78

1

2

High-throughput

0.437

High

932958

UBQL2
Ubiquilin-2

1

4

High-throughput

0.437

High

932963

TRI33
E3 ubiquitin-protein ligase TRIM33

1

3

High-throughput

0.437

High

932964

HDAC5
Histone deacetylase 5

1

1

High-throughput

0.437

High

294677

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

932868

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

254908

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.407

High

260848

RAMP3
Receptor activity-modifying protein 3

1

2

High-throughput

0.407

High

397921

ANGI
Angiogenin

1

1

High-throughput

0.407

High

628401

KLK2
Kallikrein-2

1

9

High-throughput

0.407

High

844744

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.407

High

932881

S39AC
Zinc transporter ZIP12

1

2

High-throughput

0.407

High

932922

SO4A1
Solute carrier organic anion transporter family member 4A1

1

1

High-throughput

0.407

High

932938

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.407

High

932961

SO3A1
Solute carrier organic anion transporter family member 3A1

1

3

High-throughput

0.407

High

932891

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.299

High

932925

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.299

High

932906

UBR2
E3 ubiquitin-protein ligase UBR2

2

0

Small-scale

0.298

High

932914

DOCK8
Dedicator of cytokinesis protein 8

2

0

High-throughput

0.298

High

66788

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

0

High-throughput

0.279

Low

866932

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

932874

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

0

High-throughput

0.279

Low

932878

VATF
V-type proton ATPase subunit F

1

0

High-throughput

0.279

Low

932888

EDC4
Enhancer of mRNA-decapping protein 4

1

0

High-throughput

0.279

Low

932896

HAKAI
E3 ubiquitin-protein ligase Hakai

1

0

Small-scale

0.279

Low

932898

ATS13
A disintegrin and metalloproteinase with thrombospondin motifs 13

1

0

High-throughput

0.279

Low

932926

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.279

Low

932937

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

932941

KDM4C
Lysine-specific demethylase 4C

1

0

High-throughput

0.279

Low

932947

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.279

Low

932955

EMC3
ER membrane protein complex subunit 3

1

0

High-throughput

0.279

Low

932966

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

70829

SYC1L
Synaptonemal complex central element protein 1-like

1

0

High-throughput

0.251

Low

125353

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

128889

MEN1
Menin

1

0

High-throughput

0.249

Low

297524

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.249

Low

458345

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.249

Low

587434

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.249

Low

878835

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

886381

CTCF
Transcriptional repressor CTCF

1

0

Small-scale

0.249

Low

932846

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.249

Low

932867

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.249

Low

932869

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

932882

AKIR2
Akirin-2

1

0

Small-scale

0.249

Low

932886

ANO7
Anoctamin-7

1

0

Small-scale

0.249

Low

932895

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

932907

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.249

Low

932912

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

932921

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.249

Low

932932

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.249

Low

932951

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

619640

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low

932902

OSTB
Organic solute transporter subunit beta

1

0

High-throughput

0.232

Low

932945

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025