Protein: TYDP1
Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-)

Gene: TYDP1, TDP1
Organism: Homo sapiens
Interactions: 40
UniProt ID: Q9NUW8

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0003690 - double-stranded DNA binding
GO:0003697 - single-stranded DNA binding
GO:0004527 - exonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

446546

DPOLB
DNA polymerase beta

4

0

High-throughput

0.670

High

892634

DNLI3
DNA ligase 3

4

0

Small-scale

0.670

High

617744

XRCC1
DNA repair protein XRCC1

4

0

Small-scale

0.664

High

1309439

APLF
Aprataxin and PNK-like factor

3

0

High-throughput

0.638

High

877246

KC1D
Casein kinase I isoform delta

2

0

High-throughput

0.602

High

1086189

CETN1
Centrin-1

2

0

High-throughput

0.602

High

911127

IMA1
Importin subunit alpha-1

2

0

High-throughput

0.595

High

890407

NU153
Nuclear pore complex protein Nup153

2

0

High-throughput

0.585

High

487805

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.536

High

907600

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.513

High

1065456

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1275342

APTX
Aprataxin

1

0

High-throughput

0.513

High

1349438

POC1B
POC1 centriolar protein homolog B

1

0

High-throughput

0.513

High

1450170

CHTOP
Chromatin target of PRMT1 protein

1

0

High-throughput

0.513

High

814581

FEN1
Flap endonuclease 1

1

0

High-throughput

0.493

High

62338

A4FUJ8
MKL1 protein

1

0

High-throughput

0.493

High

297692

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.493

High

856946

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.493

High

1066033

VAC14
Protein VAC14 homolog

1

0

High-throughput

0.493

High

1150005

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.493

High

1252781

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

High-throughput

0.493

High

1307993

SPA2L
Spermatogenesis-associated protein 2-like protein

1

0

High-throughput

0.493

High

1326112

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.493

High

1419413

LDH6B
L-lactate dehydrogenase A-like 6B

1

0

High-throughput

0.493

High

1436044

DCR1B
5' exonuclease Apollo

1

0

High-throughput

0.493

High

1449063

RASF1
Ras association domain-containing protein 1

1

0

High-throughput

0.493

High

508706

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

162714

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.458

High

583900

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

0

Small-scale

0.458

High

696644

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

981130

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1054795

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

1102271

ATM
Serine-protein kinase ATM

1

0

Small-scale

0.458

High

1255758

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1448834

TMPS4
Transmembrane protease serine 4

1

0

High-throughput

0.458

High

1384394

SO4A1
Solute carrier organic anion transporter family member 4A1

1

1

High-throughput

0.445

High

1450168

SO3A1
Solute carrier organic anion transporter family member 3A1

1

1

High-throughput

0.445

High

1211874

CHCH9
Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial

1

0

High-throughput

0.426

High

1292294

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

1450169

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

Small-scale

0.426

High


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Last updated: 11Aug2025