Protein: SHRPN
Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1)

Gene: SHRPN, SHARPIN
Organism: Homo sapiens
Interactions: 186
UniProt ID: Q9H0F6

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005829 - cytosol
GO:0007005 - mitochondrion organization
GO:0010803 - regulation of tumor necrosis factor-mediated signaling pathway
GO:0030262 - apoptotic nuclear changes

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1327693

SHRPN
Sharpin

3

4

Small-scale

0.847

High

1290057

RNF31
E3 ubiquitin-protein ligase RNF31

32

4

Small-scale

0.770

High

1317079

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

15

5

Small-scale

0.762

High

352701

TNFA
Tumor necrosis factor

17

3

Small-scale

0.762

High

1327728

NEMO
NF-kappa-B essential modulator

9

3

Small-scale

0.754

High

1285700

OTUL
Ubiquitin thioesterase otulin

5

1

Small-scale

0.702

High

476348

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

3

Small-scale

0.686

High

738697

TNR3
Tumor necrosis factor receptor superfamily member 3

3

5

High-throughput

0.667

High

890838

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

3

1

Small-scale

0.664

High

595505

ITAL
Integrin alpha-L

2

7

Small-scale

0.657

High

1327698

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

3

1

Small-scale

0.656

High

584470

TNR1A
Tumor necrosis factor receptor superfamily member 1A

3

5

Small-scale

0.640

High

599730

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

2

Small-scale

0.635

High

638396

RBTN2
Rhombotin-2

2

3

High-throughput

0.628

High

1327713

RABX5
Rab5 GDP/GTP exchange factor

2

1

High-throughput

0.628

High

1023793

TRAF1
TNF receptor-associated factor 1

2

5

Small-scale

0.624

High

1327702

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

3

0

Small-scale

0.613

High

509730

UBL4A
Ubiquitin-like protein 4A

2

4

Small-scale

0.611

High

566901

ITA2
Integrin alpha-2

1

7

Small-scale

0.597

High

1134077

DCA12
DDB1- and CUL4-associated factor 12

2

0

Small-scale

0.585

High

1184858

GET4
Golgi to ER traffic protein 4 homolog

2

0

Small-scale

0.585

High

330284

BCL10
B-cell lymphoma/leukemia 10

2

1

Small-scale

0.584

High

1327712

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

2

1

Small-scale

0.584

High

1327715

SPAT2
Spermatogenesis-associated protein 2

2

1

Small-scale

0.584

High

1109263

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.580

High

443096

ITA5
Integrin alpha-5

2

7

Small-scale

0.574

High

439939

ITA2B
Integrin alpha-IIb

1

7

Small-scale

0.561

High

880218

ITA1
Integrin alpha-1

1

7

Small-scale

0.561

High

1075985

PCH2
Pachytene checkpoint protein 2 homolog

2

1

High-throughput

0.553

High

1174105

UBP54
Inactive ubiquitin carboxyl-terminal hydrolase 54

2

1

High-throughput

0.553

High

1327727

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

4

Small-scale

0.552

High

843896

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.541

High

989114

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.541

High

1316278

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

4

High-throughput

0.541

High

896969

ARP2
Actin-related protein 2

1

0

Small-scale

0.537

High

396654

ITB2
Integrin beta-2

1

2

Small-scale

0.536

High

158541

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

3

Small-scale

0.536

High

167615

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

3

Small-scale

0.536

High

201430

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

2

High-throughput

0.536

High

335314

DYR
Dihydrofolate reductase

1

1

High-throughput

0.536

High

337124

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

1

High-throughput

0.536

High

649157

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

1

High-throughput

0.536

High

845720

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.536

High

872212

RD23A
UV excision repair protein RAD23 homolog A

1

1

High-throughput

0.536

High

906788

NCS1
Neuronal calcium sensor 1

1

1

High-throughput

0.536

High

1024759

TRAF3
TNF receptor-associated factor 3

1

9

High-throughput

0.536

High

1064128

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.536

High

1114226

TBB8
Tubulin beta-8 chain

1

1

High-throughput

0.536

High

1161520

ULK3
Serine/threonine-protein kinase ULK3

1

1

High-throughput

0.536

High

1162058

TRI65
E3 ubiquitin-protein ligase TRIM65

1

4

High-throughput

0.536

High

1205694

PDPN
Podoplanin

1

1

High-throughput

0.536

High

1206221

HIPK1
Homeodomain-interacting protein kinase 1

1

1

High-throughput

0.536

High

1220111

UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

1

2

High-throughput

0.536

High

1245176

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.536

High

1326982

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

2

High-throughput

0.536

High

1327709

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

2

High-throughput

0.536

High

1327718

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

High-throughput

0.536

High

1022449

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

0

High-throughput

0.518

High

164269

ZN609
Zinc finger protein 609

1

0

High-throughput

0.513

High

203410

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

0

High-throughput

0.513

High

504733

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

665329

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.513

High

670890

GFRP
GTP cyclohydrolase 1 feedback regulatory protein

1

0

High-throughput

0.513

High

678392

GDIA
Rab GDP dissociation inhibitor alpha

1

0

High-throughput

0.513

High

830192

PRI2
DNA primase large subunit

1

0

High-throughput

0.513

High

997669

DMWD
Dystrophia myotonica WD repeat-containing protein

1

0

High-throughput

0.513

High

1077951

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.513

High

1079697

ADIPO
Adiponectin

1

0

High-throughput

0.513

High

1102018

CTC1
CST complex subunit CTC1

1

0

High-throughput

0.513

High

1160506

MEAK7
MTOR-associated protein MEAK7

1

0

High-throughput

0.513

High

1199097

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

0

High-throughput

0.513

High

1253715

ZN507
Zinc finger protein 507

1

0

High-throughput

0.513

High

1268164

LAR4B
La-related protein 4B

1

0

High-throughput

0.513

High

1305251

PHB2
Prohibitin-2

1

0

High-throughput

0.513

High

1305688

ATX2
Ataxin-2

1

0

High-throughput

0.513

High

1313242

TCAB1
Telomerase Cajal body protein 1

1

0

High-throughput

0.513

High

1318090

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.513

High

1327697

ZN703
Zinc finger protein 703

1

0

High-throughput

0.513

High

1327708

MIOS
GATOR2 complex protein MIOS

1

0

High-throughput

0.513

High

1327711

DNJB4
DnaJ homolog subfamily B member 4

1

0

High-throughput

0.513

High

1327721

NISCH
Nischarin

1

0

High-throughput

0.513

High

87314

UMAD1
UBAP1-MVB12-associated

1

1

High-throughput

0.489

High

1165080

MOXD1
DBH-like monooxygenase protein 1

1

1

High-throughput

0.489

High

1204888

VP37D
Vacuolar protein sorting-associated protein 37D

1

1

High-throughput

0.489

High

1245412

O52N4
Olfactory receptor 52N4

1

1

High-throughput

0.489

High

1245492

O52N5
Olfactory receptor 52N5

1

1

High-throughput

0.489

High

1274343

MED12
Mediator of RNA polymerase II transcription subunit 12

1

2

High-throughput

0.489

High

1318270

ULBP3
UL16-binding protein 3

1

1

High-throughput

0.489

High

1327710

TEN3
Teneurin-3

1

1

High-throughput

0.489

High

1138861

OTU1
Ubiquitin thioesterase OTU1

1

1

Small-scale

0.481

High

896818

ARP3
Actin-related protein 3

1

0

Small-scale

0.480

High

156354

PSA7
Proteasome subunit alpha type-7

1

4

Small-scale

0.479

High

179961

TLR3
Toll-like receptor 3

1

1

Small-scale

0.479

High

370402

ESR1
Estrogen receptor

1

1

Small-scale

0.479

High

422098

LDHB
L-lactate dehydrogenase B chain

1

2

Small-scale

0.479

High

637549

PSA1
Proteasome subunit alpha type-1

1

5

Small-scale

0.479

High

638005

PSA3
Proteasome subunit alpha type-3

1

4

Small-scale

0.479

High

638194

PSA4
Proteasome subunit alpha type-4

1

5

Small-scale

0.479

High

667488

CASP1
Caspase-1

1

1

Small-scale

0.479

High

782294

NAA10
N-alpha-acetyltransferase 10

1

1

Small-scale

0.479

High

803737

BAG6
Large proline-rich protein BAG6

1

1

Small-scale

0.479

High

808913

YAP1
Transcriptional coactivator YAP1

1

3

Small-scale

0.479

High

832161

PSB2
Proteasome subunit beta type-2

1

1

Small-scale

0.479

High

893748

PSA6
Proteasome subunit alpha type-6

1

5

Small-scale

0.479

High

1025549

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

Small-scale

0.479

High

1042506

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1242650

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

2

Small-scale

0.479

High

1291573

OTUB1
Ubiquitin thioesterase OTUB1

1

1

Small-scale

0.479

High

1327694

ZBP1
Z-DNA-binding protein 1

1

1

Small-scale

0.479

High

1327703

PDLI7
PDZ and LIM domain protein 7

1

1

Small-scale

0.479

High

1327704

PRDC1
Phosphoribosyltransferase domain-containing protein 1

1

1

Small-scale

0.479

High

1327714

AGO2
Protein argonaute-2

1

1

Small-scale

0.479

High

1327716

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.479

High

1327722

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

5

Small-scale

0.479

High

1327725

TRAF6
TNF receptor-associated factor 6

1

9

Small-scale

0.479

High

1327726

RN114
E3 ubiquitin-protein ligase RNF114

1

8

Small-scale

0.479

High

2778

A0A0C4DGF1
Zinc finger and BTB domain containing 32

1

1

High-throughput

0.470

High

1306342

THIOM
Thioredoxin, mitochondrial

1

0

High-throughput

0.460

High

122086

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

Small-scale

0.458

High

153786

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.458

High

168973

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.458

High

202681

TXNL1
Thioredoxin-like protein 1

1

0

Small-scale

0.458

High

276098

CBR3
Carbonyl reductase [NADPH] 3

1

0

Small-scale

0.458

High

324022

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.458

High

352969

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

670860

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

Small-scale

0.458

High

717338

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

739407

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

0

Small-scale

0.458

High

772157

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

798758

PRS6B
26S proteasome regulatory subunit 6B

1

0

Small-scale

0.458

High

832040

PSB3
Proteasome subunit beta type-3

1

0

Small-scale

0.458

High

839119

EMD
Emerin

1

0

Small-scale

0.458

High

849268

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

0

Small-scale

0.458

High

863130

PGTB2
Geranylgeranyl transferase type-2 subunit beta

1

0

Small-scale

0.458

High

864257

CCHL
Holocytochrome c-type synthase

1

0

Small-scale

0.458

High

888216

TPIS
Triosephosphate isomerase

1

0

Small-scale

0.458

High

906121

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

Small-scale

0.458

High

916367

RL23A
Large ribosomal subunit protein uL23

1

0

Small-scale

0.458

High

916846

RS6
Small ribosomal subunit protein eS6

1

0

Small-scale

0.458

High

962967

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

1057107

EPN4
Clathrin interactor 1

1

0

Small-scale

0.458

High

1252756

NANP
N-acylneuraminate-9-phosphatase

1

0

Small-scale

0.458

High

1255591

NEK7
Serine/threonine-protein kinase Nek7

1

0

Small-scale

0.458

High

1292211

AURKB
Aurora kinase B

1

0

High-throughput

0.458

High

1293810

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

Small-scale

0.458

High

1304870

TSNAX
Translin-associated protein X

1

0

Small-scale

0.458

High

1305765

METH
Methionine synthase

1

0

Small-scale

0.458

High

1327696

STEEP
STING ER exit protein

1

0

Small-scale

0.458

High

1327699

RAB18
Ras-related protein Rab-18

1

0

Small-scale

0.458

High

1327700

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

Small-scale

0.458

High

1327701

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

0

Small-scale

0.458

High

1327707

DECR2
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

1

0

Small-scale

0.458

High

1327717

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

Small-scale

0.458

High

1034268

MKRN4
Putative E3 ubiquitin-protein ligase makorin-4

1

2

High-throughput

0.445

High

1036065

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

Small-scale

0.445

High

1036343

BIRC2
Baculoviral IAP repeat-containing protein 2

1

3

Small-scale

0.445

High

1327723

ZBT32
Zinc finger and BTB domain-containing protein 32

1

1

High-throughput

0.439

High

1270266

AP2C
Transcription factor AP-2 gamma

1

0

High-throughput

0.438

High

973994

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

2

Small-scale

0.437

High

789184

HELZ
Probable helicase with zinc finger domain

1

0

High-throughput

0.426

High

506135

ITAM
Integrin alpha-M

1

7

Small-scale

0.408

High

1032205

ITAD
Integrin alpha-D

1

7

Small-scale

0.408

High

1327720

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

4

Small-scale

0.408

High

421290

LIPF
Gastric triacylglycerol lipase

3

0

High-throughput

0.347

High

1216074

KRA71
Keratin-associated protein 7-1

2

0

High-throughput

0.316

High

254192

FZD7
Frizzled-7

1

0

High-throughput

0.279

Low

304727

S1PR2
Sphingosine 1-phosphate receptor 2

1

0

High-throughput

0.279

Low

1057857

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.279

Low

1102954

QRIC1
Transcriptional regulator QRICH1

1

0

High-throughput

0.279

Low

1145630

F91A1
Protein FAM91A1

1

0

High-throughput

0.279

Low

1148612

C19L1
CWF19-like protein 1

1

0

High-throughput

0.279

Low

1152470

RTL6
Retrotransposon Gag-like protein 6

1

0

High-throughput

0.279

Low

1167308

BCOR
BCL-6 corepressor

1

0

High-throughput

0.279

Low

1204148

NIT1
Deaminated glutathione amidase

1

0

High-throughput

0.279

Low

1287784

ORAI1
Calcium release-activated calcium channel protein 1

1

0

High-throughput

0.279

Low

1298909

SAM11
Sterile alpha motif domain-containing protein 11

1

0

High-throughput

0.279

Low

1301849

CSRN1
Cysteine/serine-rich nuclear protein 1

1

0

High-throughput

0.279

Low

1327705

SEM4G
Semaphorin-4G

1

0

High-throughput

0.279

Low

1327706

ZCHC3
Zinc finger CCHC domain-containing protein 3

1

0

High-throughput

0.279

Low

1327719

SATB2
DNA-binding protein SATB2

1

0

High-throughput

0.279

Low

1327724

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.279

Low

1327695

PPIL3
Peptidyl-prolyl cis-trans isomerase-like 3

1

0

Small-scale

0.261

Low

521301

SKI
Ski oncogene

1

0

Small-scale

0.249

Low

1166718

WDR82
WD repeat-containing protein 82

1

0

Small-scale

0.249

Low

673765

BKRB2
B2 bradykinin receptor

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024