Protein: CAST1
Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3)

Gene: CAST1, CASTOR1
Organism: Homo sapiens
Interactions: 17
UniProt ID: Q8WTX7

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0034198 - cellular response to amino acid starvation
GO:0034618 - arginine binding
GO:0042802 - identical protein binding
GO:0140299 - molecular sensor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

65853

CAST2
Cytosolic arginine sensor for mTORC1 subunit 2

4

2

Small-scale

0.914

High

1356203

CAST1
Cytosolic arginine sensor for mTORC1 subunit 1

4

2

Small-scale

0.904

High

1356208

MIOS
GATOR2 complex protein MIOS

7

3

Small-scale

0.746

High

1356206

WDR24
GATOR2 complex protein WDR24

5

3

Small-scale

0.720

High

1245316

WDR59
GATOR2 complex protein WDR59

5

3

Small-scale

0.718

High

1356205

ZC21A
Zinc finger C2HC domain-containing protein 1A

6

1

High-throughput

0.674

High

1157408

PSMD5
26S proteasome non-ATPase regulatory subunit 5

2

0

High-throughput

0.580

High

1216355

ZC21B
Zinc finger C2HC domain-containing protein 1B

2

1

High-throughput

0.553

High

488133

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

1

High-throughput

0.536

High

625834

RXRA
Retinoic acid receptor RXR-alpha

1

1

High-throughput

0.536

High

1356209

PLAT4
Phospholipase A and acyltransferase 4

1

1

High-throughput

0.515

High

728348

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.480

High

167168

T4S5
Transmembrane 4 L6 family member 5

1

0

Small-scale

0.458

High

945677

SESN2
Sestrin-2

1

0

Small-scale

0.458

High

1356207

RN167
E3 ubiquitin-protein ligase RNF167

1

0

Small-scale

0.458

High

1356204

TMA16
Translation machinery-associated protein 16

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025