Protein: LIN2
Protein lin-2 (Abnormal cell lineage protein 2)

Gene: LIN2, lin-2
Organism: Caenorhabditis elegans
Interactions: 74
UniProt ID: P54936

Gene Ontology (top 5):
GO:0004713 - protein tyrosine kinase activity
GO:0005102 - signaling receptor binding
GO:0005159 - insulin-like growth factor receptor binding
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

933112

Q9U245
Protein lin-7 homolog

6

20

Small-scale

0.947

High

196162

LIN10
Protein lin-10

6

20

Small-scale

0.945

High

111354

G5ED33
Epidermal growth factor receptor pathway substrate 8 splice variant A

4

11

Small-scale

0.875

High

562921

GLP1
Protein glp-1 [Cleaved into: glp-1/Notch intracellular domain]

2

5

High-throughput

0.743

High

933089

SPK1
Serine/threonine-protein kinase spk-1

2

9

High-throughput

0.743

High

113202

UBQL
Ubiquilin

3

6

High-throughput

0.733

High

661899

UN104
Kinesin-like protein unc-104

1

15

Small-scale

0.713

High

933097

LIPA
Liprin-alpha

1

6

Small-scale

0.713

High

933110

INSR
Insulin-like receptor

1

20

Small-scale

0.621

High

113765

HIF1
Hypoxia-inducible factor 1

3

1

High-throughput

0.599

High

759461

CHTB1
Chitin binding domain

3

6

High-throughput

0.599

High

933090

Q17746
ZZ-type domain-containing protein

3

3

High-throughput

0.599

High

933102

MIG5
Segment polarity protein dishevelled homolog mig-5

1

20

High-throughput

0.590

High

304303

PPN1
Papilin

1

3

High-throughput

0.587

High

232481

O44490
ELKS/RAB6-interacting/CAST family member 2

2

5

High-throughput

0.584

High

232201

O44444
RRM domain-containing protein

1

0

High-throughput

0.584

High

67192

A6PVA5
ATP synthase subunit s, mitochondrial

3

1

High-throughput

0.583

High

760738

KTNA1
Meiotic spindle formation protein mei-1

2

1

High-throughput

0.576

High

790968

UNC87
Protein unc-87

2

2

High-throughput

0.559

High

933111

Q9TZK8
J domain-containing protein

2

1

High-throughput

0.553

High

109588

G5EBE3
CBF1-interacting co-repressor CIR N-terminal domain-containing protein

2

1

High-throughput

0.542

High

933091

Q17796
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

3

High-throughput

0.542

High

933106

TOP2
DNA topoisomerase 2 top-2

1

1

High-throughput

0.541

High

198215

O18672
F15C11.2

1

11

High-throughput

0.528

High

933093

Q18529
Chitin-binding type-2 domain-containing protein

2

7

High-throughput

0.526

High

933099

Q21225
Protein VAC14 homolog

2

1

High-throughput

0.526

High

933114

LIN41
Protein lin-41

2

14

High-throughput

0.526

High

933115

OSTA3
Organic solute transporter alpha-like protein 3

1

0

High-throughput

0.518

High

144524

O01331
Galectin

1

4

High-throughput

0.494

High

933095

NDUS6
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

1

High-throughput

0.494

High

116185

H2L2C8
Alpha-actinin, sarcomeric

1

12

High-throughput

0.481

High

196545

O17905
Moesin/ezrin/radixin homolog 1

1

20

Small-scale

0.481

High

933103

Q22387
Centrosomal protein of 162 kDa

1

4

High-throughput

0.464

High

933104

Q23158
Alpha-actinin, sarcomeric

1

12

High-throughput

0.457

High

933117

Q9XVU8
Alpha-actinin, sarcomeric

1

12

High-throughput

0.457

High

91967

D0IMZ6
FiLamiN

1

4

High-throughput

0.439

High

113251

G5EFG1
PDZ and LIM domain protein Zasp

1

2

High-throughput

0.439

High

196657

O17977
Cell wall protein DAN4

1

1

High-throughput

0.439

High

232029

HMP2
Beta-catenin-like protein hmp-2

1

7

High-throughput

0.439

High

933100

EPI1
Laminin-like protein epi-1

1

10

High-throughput

0.439

High

96272

E9P875
Neurexin-3-beta

1

1

High-throughput

0.437

High

84492

B7WNA3
Cell wall protein DAN4

1

1

High-throughput

0.417

High

91959

D0IMZ5
Calponin-homology

1

14

High-throughput

0.417

High

112851

G5EEV6
Laminin alpha

1

10

High-throughput

0.417

High

116248

H2L2I2
Armadillo/beta-catenin-like repeat protein

1

7

High-throughput

0.417

High

195392

O16314
ATP synthase subunit s, mitochondrial

1

1

High-throughput

0.417

High

933096

VPS39
Vacuolar protein sorting-associated protein 39 homolog

1

7

High-throughput

0.417

High

933094

Q18624
SAND domain-containing protein

5

0

High-throughput

0.375

High

263786

O61711
RRM domain-containing protein

3

0

High-throughput

0.342

High

604319

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

3

0

High-throughput

0.342

High

758557

TYR1
Putative tyrosinase-like protein tyr-1

3

0

High-throughput

0.342

High

759831

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

3

0

High-throughput

0.342

High

857670

SUMV1
Protein sumv-1

3

0

High-throughput

0.342

High

933101

MEP1
MOG interacting and ectopic P-granules protein 1

3

0

High-throughput

0.342

High

933107

Q93831
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

3

0

High-throughput

0.342

High

234227

CPL1
Cathepsin L-like

2

0

High-throughput

0.300

High

759693

EI2BA
Translation initiation factor eIF2B subunit alpha

2

0

High-throughput

0.300

High

933108

HYLS1
Centriolar and ciliogenesis-associated protein hyls-1

2

0

High-throughput

0.300

High

933113

GYS
Glycogen [starch] synthase

2

0

High-throughput

0.300

High

111512

G5ED81
C09G4.4 protein

1

0

High-throughput

0.282

High

195240

O16208
PAN-3 domain-containing protein

1

0

High-throughput

0.282

High

303846

O76412
G_PROTEIN_RECEP_F1_2 domain-containing protein

1

0

High-throughput

0.282

High

933092

Q18238
Intrinsically Disordered Protein, class B

1

0

High-throughput

0.282

High

933098

Q21083
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.282

High

933105

Q23615
SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein

1

0

High-throughput

0.282

High

933109

Q95YA5
DYnein Light chain, Axonemal p28 type

1

0

High-throughput

0.282

High

933116

Q9XV58
ShKT domain-containing protein

1

0

High-throughput

0.282

High

438856

VIT5
Vitellogenin-5

1

0

High-throughput

0.265

Low

84497

B7WNB1
Geranylgeranyl transferase type I subunit beta

1

0

High-throughput

0.251

Low

86646

B9WRT8
C3H1-type domain-containing protein

1

0

High-throughput

0.251

Low

109122

G4SL51
DUF1080 domain-containing protein

1

0

High-throughput

0.251

Low

84494

B7WNB0
Geranylgeranyl transferase type I subunit beta

1

0

High-throughput

0.238

Low

231910

O44144
PERMeable eggshell

1

0

High-throughput

0.238

Low

933088

LST1
Lateral signaling target 1 protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025