Protein: PTN11
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2)

Gene: PTN11, Ptpn11
Organism: Mus musculus
Interactions: 55
UniProt ID: P35235

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0001784 - phosphotyrosine residue binding
GO:0004721 - phosphoprotein phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

719305

GRB2
Growth factor receptor-bound protein 2

3

20

Small-scale

0.827

High

643059

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.806

High

719297

IL6RB
Interleukin-6 receptor subunit beta

2

18

Small-scale

0.754

High

719295

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

7

13

Small-scale

0.738

High

719322

ITSN1
Intersectin-1

1

9

Small-scale

0.713

High

546284

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.691

High

719319

GAB1
GRB2-associated-binding protein 1

4

14

Small-scale

0.676

High

719288

STA5A
Signal transducer and activator of transcription 5A

1

17

Small-scale

0.665

High

719300

TIE2
Angiopoietin-1 receptor

1

20

Small-scale

0.647

High

719293

LIRB3
Leukocyte immunoglobulin-like receptor subfamily B member 3

5

20

Small-scale

0.641

High

719303

Q3ZB59
Growth factor receptor bound protein 2-associated protein 2

3

15

Small-scale

0.640

High

193376

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.625

High

337619

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.618

High

562607

FES
Tyrosine-protein kinase Fes/Fps

1

20

Small-scale

0.618

High

710124

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.618

High

719296

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.618

High

719299

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

719315

ITCH
E3 ubiquitin-protein ligase Itchy

1

1

Small-scale

0.618

High

719318

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

2

Small-scale

0.618

High

719302

CBLB
E3 ubiquitin-protein ligase CBL-B

2

13

Small-scale

0.584

High

719314

FRS2
Fibroblast growth factor receptor substrate 2

2

6

Small-scale

0.584

High

719286

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

17

Small-scale

0.575

High

719306

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.575

High

610552

CBL
E3 ubiquitin-protein ligase CBL

2

12

Small-scale

0.571

High

677626

CTND1
Catenin delta-1

1

20

Small-scale

0.561

High

660216

I23O1
Indoleamine 2,3-dioxygenase 1

1

1

Small-scale

0.536

High

682308

CEAM1
Carcinoembryonic antigen-related cell adhesion molecule 1

1

20

Small-scale

0.536

High

719287

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

13

High-throughput

0.536

High

719301

PECA1
Platelet endothelial cell adhesion molecule

1

18

Small-scale

0.536

High

719311

BTLA
B- and T-lymphocyte attenuator

2

2

Small-scale

0.533

High

719307

LRB4A
Leukocyte immunoglobulin-like receptor subfamily B member 4A

2

20

Small-scale

0.514

High

93618

E9Q604
Integrin alpha M

1

11

High-throughput

0.501

High

719298

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

14

High-throughput

0.500

High

719309

RIGI
Antiviral innate immune response receptor RIG-I

1

4

Small-scale

0.484

High

192915

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

5

High-throughput

0.479

High

291442

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

8

Small-scale

0.479

High

562609

GHR
Growth hormone receptor

1

20

Small-scale

0.479

High

580492

FAS
Fatty acid synthase

1

2

Small-scale

0.479

High

679054

HXA10
Homeobox protein Hox-A10

1

3

Small-scale

0.479

High

719289

LEPR
Leptin receptor

1

18

Small-scale

0.479

High

719291

TRAF6
TNF receptor-associated factor 6

1

9

Small-scale

0.479

High

719292

DAB1
Disabled homolog 1

1

7

Small-scale

0.479

High

719312

TNR14
Tumor necrosis factor receptor superfamily member 14

1

11

Small-scale

0.479

High

719317

1433B
14-3-3 protein beta/alpha

1

9

Small-scale

0.479

High

719321

TBK1
Serine/threonine-protein kinase TBK1

1

11

Small-scale

0.479

High

719294

SMRC1
SWI/SNF complex subunit SMARCC1

1

2

High-throughput

0.457

High

719316

Q8K4V6
Paired immunoglobulin-like receptor B

1

20

Small-scale

0.457

High

719290

CAV3
Caveolin-3

1

5

High-throughput

0.445

High

719323

GAB2
GRB2-associated-binding protein 2

1

15

High-throughput

0.445

High

719313

SIG10
Sialic acid-binding Ig-like lectin 10

1

20

Small-scale

0.442

High

719304

LC7L3
Luc7-like protein 3

1

0

High-throughput

0.438

High

719310

CLM8
CMRF35-like molecule 8

1

5

Small-scale

0.437

High

719320

COP1
E3 ubiquitin-protein ligase COP1

1

5

Small-scale

0.437

High

719308

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024