Protein: KIT
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)

Gene: KIT
Organism: Homo sapiens
Interactions: 101
UniProt ID: P10721

Gene Ontology (top 5):
GO:0001541 - ovarian follicle development
GO:0001650 - fibrillar center
GO:0001669 - acrosomal vesicle
GO:0002020 - protease binding
GO:0002244 - hematopoietic progenitor cell differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

499253

GRB2
Growth factor receptor-bound protein 2

10

20

Small-scale

0.976

High

499235

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

9

20

Small-scale

0.965

High

499230

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

5

18

Small-scale

0.918

High

499232

SCF
Kit ligand

4

1

Small-scale

0.899

High

499259

PTN11
Tyrosine-protein phosphatase non-receptor type 11

4

20

Small-scale

0.885

High

147481

SOCS6
Suppressor of cytokine signaling 6

3

20

Small-scale

0.879

High

499236

PTN6
Tyrosine-protein phosphatase non-receptor type 6

3

20

Small-scale

0.876

High

433539

LYN
Tyrosine-protein kinase Lyn

3

20

Small-scale

0.875

High

499242

TEC
Tyrosine-protein kinase Tec

3

20

Small-scale

0.870

High

499247

CRK
Adapter molecule crk

3

20

Small-scale

0.863

High

499267

GRB7
Growth factor receptor-bound protein 7

3

20

Small-scale

0.849

High

499222

SRC
Proto-oncogene tyrosine-protein kinase Src

3

20

Small-scale

0.845

High

129178

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

3

20

Small-scale

0.843

High

499238

STAT1
Signal transducer and activator of transcription 1-alpha/beta

2

13

Small-scale

0.819

High

499220

KIT
Mast/stem cell growth factor receptor Kit

2

19

Small-scale

0.806

High

181778

SOCS1
Suppressor of cytokine signaling 1

2

20

Small-scale

0.800

High

433226

YES
Tyrosine-protein kinase Yes

2

20

Small-scale

0.799

High

499293

SH2B3
SH2B adapter protein 3

2

20

Small-scale

0.799

High

411567

LCK
Tyrosine-protein kinase Lck

2

20

Small-scale

0.789

High

499241

MATK
Megakaryocyte-associated tyrosine-protein kinase

2

20

Small-scale

0.778

High

499248

CRKL
Crk-like protein

2

20

Small-scale

0.768

High

499250

STA5B
Signal transducer and activator of transcription 5B

2

13

Small-scale

0.768

High

499263

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.740

High

426980

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

17

Small-scale

0.724

High

499265

BMPR2
Bone morphogenetic protein receptor type-2

1

9

Small-scale

0.724

High

499285

DOK1
Docking protein 1

1

10

Small-scale

0.724

High

146585

SOCS2
Suppressor of cytokine signaling 2

1

20

High-throughput

0.692

High

147381

SOCS3
Suppressor of cytokine signaling 3

1

20

High-throughput

0.692

High

208982

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.692

High

256847

SOCS5
Suppressor of cytokine signaling 5

1

20

High-throughput

0.692

High

275165

GRAP2
GRB2-related adapter protein 2

1

20

High-throughput

0.692

High

275529

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

20

High-throughput

0.692

High

337322

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.692

High

426940

FES
Tyrosine-protein kinase Fes/Fps

1

20

High-throughput

0.692

High

442765

HCK
Tyrosine-protein kinase HCK

1

20

High-throughput

0.692

High

454791

FGR
Tyrosine-protein kinase Fgr

1

20

High-throughput

0.692

High

499225

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.692

High

499228

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

18

High-throughput

0.692

High

499231

RASA1
Ras GTPase-activating protein 1

1

20

High-throughput

0.692

High

499237

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.692

High

499243

TXK
Tyrosine-protein kinase TXK

1

20

High-throughput

0.692

High

499244

ABL2
Tyrosine-protein kinase ABL2

1

20

High-throughput

0.692

High

499245

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

High-throughput

0.692

High

499246

KSYK
Tyrosine-protein kinase SYK

1

20

High-throughput

0.692

High

499249

BLK
Tyrosine-protein kinase Blk

1

20

High-throughput

0.692

High

499255

3BP2
SH3 domain-binding protein 2

1

3

High-throughput

0.692

High

499256

SHC2
SHC-transforming protein 2

1

20

High-throughput

0.692

High

499266

PTK6
Protein-tyrosine kinase 6

1

20

High-throughput

0.692

High

499269

SHB
SH2 domain-containing adapter protein B

1

20

High-throughput

0.692

High

499272

TENS2
Tensin-2

1

14

High-throughput

0.692

High

499274

SHC4
SHC-transforming protein 4

1

20

High-throughput

0.692

High

499277

BLNK
B-cell linker protein

1

20

High-throughput

0.692

High

499279

SHC3
SHC-transforming protein 3

1

20

High-throughput

0.692

High

499280

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

20

High-throughput

0.692

High

499284

HSH2D
Hematopoietic SH2 domain-containing protein

1

20

High-throughput

0.692

High

499287

SLAP2
Src-like-adapter 2

1

20

High-throughput

0.692

High

499288

TENS1
Tensin-1

1

14

High-throughput

0.692

High

499289

SH22A
SH2 domain-containing protein 2A

1

20

High-throughput

0.692

High

499291

VAV3
Guanine nucleotide exchange factor VAV3

1

20

High-throughput

0.692

High

499226

CTLA4
Cytotoxic T-lymphocyte protein 4

1

1

High-throughput

0.691

High

499227

IL7RA
Interleukin-7 receptor subunit alpha

1

0

Small-scale

0.687

High

499264

GRAP
GRB2-related adapter protein

1

20

Small-scale

0.681

High

499234

CBL
E3 ubiquitin-protein ligase CBL

4

20

Small-scale

0.680

High

499251

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.647

High

499261

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

19

High-throughput

0.647

High

499282

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

7

Small-scale

0.647

High

499271

PTN20
Tyrosine-protein phosphatase non-receptor type 20

1

20

High-throughput

0.621

High

155828

SH21B
SH2 domain-containing protein 1B

1

20

High-throughput

0.619

High

243125

SH21A
SH2 domain-containing protein 1A

1

20

High-throughput

0.619

High

499273

TENS3
Tensin-3

1

13

High-throughput

0.619

High

499275

SH2D3
SH2 domain-containing protein 3C

1

20

High-throughput

0.619

High

499292

STAP1
Signal-transducing adaptor protein 1

1

3

High-throughput

0.619

High

238337

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

411962

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.618

High

499224

PGFRA
Platelet-derived growth factor receptor alpha

1

19

Small-scale

0.618

High

499239

STA5A
Signal transducer and activator of transcription 5A

1

13

Small-scale

0.618

High

499270

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

16

Small-scale

0.618

High

499278

SOCS4
Suppressor of cytokine signaling 4

1

20

Small-scale

0.618

High

499281

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

15

Small-scale

0.618

High

499283

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

Small-scale

0.618

High

499258

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

Small-scale

0.553

High

499286

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

12

High-throughput

0.541

High

499229

INAR1
Interferon alpha/beta receptor 1

1

9

High-throughput

0.536

High

499268

IRF3
Interferon regulatory factor 3

1

1

High-throughput

0.536

High

280015

MPDZ
Multiple PDZ domain protein

1

7

Small-scale

0.527

High

499276

STYX
Serine/threonine/tyrosine-interacting protein

1

13

High-throughput

0.494

High

296263

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

1

Small-scale

0.479

High

445999

CD63
CD63 antigen

1

7

Small-scale

0.479

High

499221

BCR
Breakpoint cluster region protein

1

16

Small-scale

0.479

High

499223

ENPL
Endoplasmin

1

16

Small-scale

0.479

High

499233

CD9
CD9 antigen

1

7

Small-scale

0.479

High

499240

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

19

Small-scale

0.479

High

499252

CD81
CD81 antigen

1

8

Small-scale

0.479

High

499254

ACTS
Actin, alpha skeletal muscle

1

3

Small-scale

0.479

High

499257

CLH1
Clathrin heavy chain 1

1

2

Small-scale

0.479

High

499262

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

Small-scale

0.479

High

499290

PLCE1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

1

18

Small-scale

0.479

High

130709

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.458

High

499260

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

Small-scale

0.458

High

496159

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High


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Last updated: 15 Jul 2024