Protein: GSH1
Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase)

Gene: GSH1, GCLC
Organism: Homo sapiens
Interactions: 28
UniProt ID: P48506

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004357 - glutamate-cysteine ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

873702

GSH0
Glutamate--cysteine ligase regulatory subunit

5

5

Small-scale

0.720

High

241045

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

873716

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.559

High

873704

CUL3
Cullin-3

1

1

High-throughput

0.479

High

873707

NF2L2
Nuclear factor erythroid 2-related factor 2

1

1

Small-scale

0.479

High

345510

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

429504

JUN
Transcription factor Jun

1

0

Small-scale

0.458

High

464873

SP1
Transcription factor Sp1

1

0

High-throughput

0.458

High

814483

FEN1
Flap endonuclease 1

1

0

High-throughput

0.458

High

873703

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

873706

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

873709

FTM
Protein fantom

1

0

High-throughput

0.458

High

873705

CUL4A
Cullin-4A

1

1

High-throughput

0.437

High

873713

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

873715

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

873710

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

2

0

High-throughput

0.328

High

142204

CCL22
C-C motif chemokine 22

1

0

High-throughput

0.282

High

873714

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.279

Low

873708

LARGN
Protein Largen

1

0

High-throughput

0.269

Low

105548

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

588164

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

612930

EGR1
Early growth response protein 1

1

0

High-throughput

0.249

Low

694887

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

767661

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

873711

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

873712

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.249

Low

873717

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.249

Low

330074

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025