Protein: TYW3
tRNA wybutosine-synthesizing protein 3 homolog (tRNA-yW-synthesizing protein 3) (EC 2.1.1.282) (tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase)

Gene: TYW3
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q6IPR3

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0008175 - tRNA methyltransferase activity
GO:0030488 - tRNA methylation
GO:0031591 - wybutosine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

122791

KIF2A
Kinesin-like protein KIF2A

2

2

High-throughput

0.628

High

1234701

NELL1
Protein kinase C-binding protein NELL1

2

2

High-throughput

0.628

High

1234707

NELL2
Protein kinase C-binding protein NELL2

2

3

High-throughput

0.628

High

1234708

KIF2C
Kinesin-like protein KIF2C

2

2

High-throughput

0.628

High

1234709

ZKSC3
Zinc finger protein with KRAB and SCAN domains 3

2

1

High-throughput

0.628

High

251774

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

2

0

High-throughput

0.602

High

480824

LEG1
Galectin-1

2

0

High-throughput

0.602

High

944817

PCBP3
Poly(rC)-binding protein 3

2

0

High-throughput

0.602

High

1234705

DCAF5
DDB1- and CUL4-associated factor 5

2

0

High-throughput

0.602

High

1234710

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

2

0

High-throughput

0.602

High

1234717

KIF3A
Kinesin-like protein KIF3A

2

0

High-throughput

0.602

High

1234704

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

1234713

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

270560

LRP4
Low-density lipoprotein receptor-related protein 4

2

2

High-throughput

0.574

High

376511

LDLR
Low-density lipoprotein receptor

2

2

High-throughput

0.574

High

654518

FBLN1
Fibulin-1

2

1

High-throughput

0.574

High

1234700

SORL
Sortilin-related receptor

2

2

High-throughput

0.574

High

1234702

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

2

1

High-throughput

0.574

High

270821

ROCK2
Rho-associated protein kinase 2

1

0

High-throughput

0.513

High

329937

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.513

High

736885

GBP1
Guanylate-binding protein 1

1

0

High-throughput

0.513

High

867795

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

High-throughput

0.513

High

1034106

PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

1

0

High-throughput

0.513

High

1150867

CIP4
Cdc42-interacting protein 4

1

0

High-throughput

0.513

High

1216366

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

1234692

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

0

High-throughput

0.513

High

1234695

MTURN
Maturin

1

0

High-throughput

0.513

High

1234696

KCD17
BTB/POZ domain-containing protein KCTD17

1

0

High-throughput

0.513

High

1234697

DDHD1
Phospholipase DDHD1

1

0

High-throughput

0.513

High

1234698

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

1234712

AGO4
Protein argonaute-4

1

0

High-throughput

0.513

High

1234718

HCFC2
Host cell factor 2

1

0

High-throughput

0.513

High

74129

VWC2L
von Willebrand factor C domain-containing protein 2-like

1

3

High-throughput

0.489

High

1180105

VWC2
Brorin

1

3

High-throughput

0.489

High

1213614

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

3

High-throughput

0.489

High

1234711

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1234714

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

873710

GSH1
Glutamate--cysteine ligase catalytic subunit

2

0

High-throughput

0.328

High

1218402

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

2

0

High-throughput

0.328

High

1234693

SYDE1
Rho GTPase-activating protein SYDE1

2

0

High-throughput

0.328

High

1234715

TINAG
Tubulointerstitial nephritis antigen

2

0

High-throughput

0.328

High

1234716

NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

2

0

High-throughput

0.328

High

287311

RF1M
Peptide chain release factor 1, mitochondrial

1

0

High-throughput

0.279

Low

298856

LYZL6
Lysozyme-like protein 6

1

0

High-throughput

0.279

Low

653726

PROZ
Vitamin K-dependent protein Z

1

0

High-throughput

0.279

Low

1090346

EPS8
Epidermal growth factor receptor kinase substrate 8

1

0

High-throughput

0.279

Low

1234694

ALPK2
Alpha-protein kinase 2

1

0

High-throughput

0.279

Low

1234699

SCFD2
Sec1 family domain-containing protein 2

1

0

High-throughput

0.279

Low

1234703

INT12
Integrator complex subunit 12

1

0

High-throughput

0.279

Low

1234706

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.279

Low

317861

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025