Protein: FEN1
Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1)

Gene: FEN1
Organism: Homo sapiens
Interactions: 171
UniProt ID: P39748

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0003684 - damaged DNA binding
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

550900

PCNA
Proliferating cell nuclear antigen

34

6

Small-scale

0.995

High

814524

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

4

2

Small-scale

0.717

High

253190

RAD1
Cell cycle checkpoint protein RAD1

4

0

Small-scale

0.651

High

814494

BLM
RecQ-like DNA helicase BLM

2

2

Small-scale

0.646

High

814515

EP300
Histone acetyltransferase p300

3

0

Small-scale

0.645

High

261704

HUS1
Checkpoint protein HUS1

3

0

Small-scale

0.639

High

355152

ACL6A
Actin-like protein 6A

2

1

High-throughput

0.628

High

708929

T2EB
Transcription initiation factor IIE subunit beta

2

1

High-throughput

0.628

High

814562

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

1

High-throughput

0.628

High

814478

FEN1
Flap endonuclease 1

1

3

High-throughput

0.618

High

814498

WDR4
tRNA

1

1

Small-scale

0.604

High

814551

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

240955

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

814479

CCNF
Cyclin-F

2

9

High-throughput

0.584

High

814506

H31
Histone H3.1

2

4

High-throughput

0.584

High

629076

CCNA2
Cyclin-A2

1

6

Small-scale

0.578

High

814565

RAD9A
Cell cycle checkpoint control protein RAD9A

2

0

Small-scale

0.569

High

697029

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

Small-scale

0.561

High

484969

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

Small-scale

0.549

High

667603

CDK2
Cyclin-dependent kinase 2

1

6

Small-scale

0.536

High

362897

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.536

High

484415

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

487036

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.536

High

541870

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

563348

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

814480

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.536

High

814493

MSH6
DNA mismatch repair protein Msh6

1

7

High-throughput

0.536

High

814497

FOXA3
Hepatocyte nuclear factor 3-gamma

1

1

High-throughput

0.536

High

814511

FOXO4
Forkhead box protein O4

1

1

High-throughput

0.536

High

814514

SSRP1
FACT complex subunit SSRP1

1

3

High-throughput

0.536

High

814516

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.536

High

814523

TRA2A
Transformer-2 protein homolog alpha

1

3

High-throughput

0.536

High

814535

H2B2E
Histone H2B type 2-E

1

3

High-throughput

0.536

High

814563

MUS81
Structure-specific endonuclease subunit MUS81

1

1

Small-scale

0.536

High

814571

FOXP3
Forkhead box protein P3

1

3

High-throughput

0.536

High

814577

GSX1
GS homeobox 1

1

1

High-throughput

0.536

High

687914

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.518

High

814492

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

High-throughput

0.518

High

292897

RNH2A
Ribonuclease H2 subunit A

1

0

High-throughput

0.513

High

361154

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

455713

H10
Histone H1.0

1

0

High-throughput

0.513

High

542364

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

611789

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

652286

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.513

High

814481

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

814491

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.513

High

814509

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

814513

HXC5
Homeobox protein Hox-C5

1

0

High-throughput

0.513

High

814522

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

814534

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.513

High

814540

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.513

High

814564

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

814566

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

814487

GSK3B
Glycogen synthase kinase-3 beta

1

5

High-throughput

0.508

High

443240

CDK1
Cyclin-dependent kinase 1

1

4

Small-scale

0.501

High

271230

CPNE3
Copine-3

1

0

High-throughput

0.493

High

814581

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.493

High

389113

FINC
Fibronectin

1

1

High-throughput

0.489

High

814495

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.481

High

185494

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

421632

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

238420

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.479

High

355444

NSD2
Histone-lysine N-methyltransferase NSD2

1

1

Small-scale

0.479

High

371359

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

400412

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

588086

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

606353

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

615495

NELFE
Negative elongation factor E

1

1

High-throughput

0.479

High

694801

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

767579

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

814482

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

814485

CENPA
Histone H3-like centromeric protein A

1

4

High-throughput

0.479

High

814489

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

7

Small-scale

0.479

High

814490

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

814496

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

814499

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

814501

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

814503

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

814504

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

814507

MAP1A
Microtubule-associated protein 1A

1

2

High-throughput

0.479

High

814508

RED1
Double-stranded RNA-specific editase 1

1

1

High-throughput

0.479

High

814510

H33
Histone H3.3

1

4

High-throughput

0.479

High

814518

RFA4
Replication protein A 30 kDa subunit

1

3

High-throughput

0.479

High

814520

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

814525

NUCG
Endonuclease G, mitochondrial

1

1

Small-scale

0.479

High

814526

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

814528

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

1

High-throughput

0.479

High

814530

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

814531

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

814532

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.479

High

814533

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

814542

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.479

High

814543

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

814555

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

814556

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

814559

DDX11
ATP-dependent DNA helicase DDX11

1

3

Small-scale

0.479

High

814572

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

814578

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.479

High

814579

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

814580

ANLN
Anillin

1

1

High-throughput

0.479

High

814582

CHPF2
Chondroitin sulfate glucuronyltransferase

1

1

High-throughput

0.479

High

814583

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

814584

FND3A
Fibronectin type-III domain-containing protein 3A

1

2

High-throughput

0.479

High

171842

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

246276

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

0

High-throughput

0.458

High

276071

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.458

High

385518

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

411498

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

426451

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.458

High

519803

ANDR
Androgen receptor

1

0

High-throughput

0.458

High

521571

H14
Histone H1.4

1

0

High-throughput

0.458

High

536650

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

557914

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

575120

IDE
Insulin-degrading enzyme

1

0

High-throughput

0.458

High

773811

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.458

High

785804

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

790991

TALDO
Transaldolase

1

0

High-throughput

0.458

High

791143

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

814483

GSH1
Glutamate--cysteine ligase catalytic subunit

1

0

High-throughput

0.458

High

814484

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

814488

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.458

High

814500

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.458

High

814505

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

814512

VIGLN
Vigilin

1

0

High-throughput

0.458

High

814519

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

814521

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

814527

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.458

High

814529

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

814544

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

814546

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

814548

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

814549

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

814552

MADD
MAP kinase-activating death domain protein

1

0

High-throughput

0.458

High

814553

DGCR8
Microprocessor complex subunit DGCR8

1

0

Small-scale

0.458

High

814567

CND3
Condensin complex subunit 3

1

0

Small-scale

0.458

High

814568

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

0

Small-scale

0.458

High

814569

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

814573

RHG39
Rho GTPase-activating protein 39

1

0

High-throughput

0.458

High

814574

AICDA
Single-stranded DNA cytosine deaminase

1

0

Small-scale

0.458

High

814575

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

814585

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

814586

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

814587

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

Small-scale

0.458

High

62400

EME2
Structure-specific endonuclease subunit EME2

1

1

Small-scale

0.445

High

429440

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

814502

1433G
14-3-3 protein gamma

1

10

High-throughput

0.445

High

814517

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

814557

EME1
Structure-specific endonuclease subunit EME1

1

1

Small-scale

0.445

High

277208

BCAS1
Breast carcinoma-amplified sequence 1

1

2

High-throughput

0.437

High

814541

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

814554

TITIN
Titin

1

1

High-throughput

0.437

High

814558

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.437

High

814576

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

529252

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

814545

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

814560

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

814561

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.426

High

814486

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

109562

G5E9W2
Hexosyltransferase

1

1

High-throughput

0.407

High

354578

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.407

High

814550

DUS19
Dual specificity protein phosphatase 19

3

0

High-throughput

0.347

High

387804

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.328

High

814538

PTCRA
Pre T-cell antigen receptor alpha

2

0

High-throughput

0.328

High

317805

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

814547

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

105486

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

814536

DOC11
Dedicator of cytokinesis protein 11

1

0

High-throughput

0.249

Low

814537

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

814539

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

814570

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025