Protein: TCP4
Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (p14)

Gene: TCP4, SUB1
Organism: Homo sapiens
Interactions: 181
UniProt ID: P53999

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001111 - RNA polymerase II promoter clearance
GO:0003697 - single-stranded DNA binding
GO:0003713 - transcription coactivator activity
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

867169

TCP4
Activated RNA polymerase II transcriptional coactivator p15

5

6

Small-scale

0.922

High

867179

CSK21
Casein kinase II subunit alpha

2

1

Small-scale

0.633

High

435020

SP1
Transcription factor Sp1

2

1

Small-scale

0.595

High

703364

CSTF2
Cleavage stimulation factor subunit 2

1

1

Small-scale

0.586

High

867176

RL11
Large ribosomal subunit protein uL5

2

0

Small-scale

0.585

High

304089

UBR5
E3 ubiquitin-protein ligase UBR5

2

2

Small-scale

0.584

High

625263

CDK2
Cyclin-dependent kinase 2

2

3

High-throughput

0.584

High

132793

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

386372

P53
Cellular tumor antigen p53

1

1

Small-scale

0.578

High

867189

EP300
Histone acetyltransferase p300

2

0

Small-scale

0.577

High

779083

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

742158

SYUA
Alpha-synuclein

2

0

High-throughput

0.547

High

867194

REST
RE1-silencing transcription factor

1

0

Small-scale

0.537

High

867244

OTUD5
OTU domain-containing protein 5

1

0

Small-scale

0.537

High

867271

RCOR1
REST corepressor 1

1

0

Small-scale

0.537

High

162540

XPO1
Exportin-1

1

2

High-throughput

0.536

High

734897

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

2

High-throughput

0.536

High

850875

HDGF
Hepatoma-derived growth factor

1

2

High-throughput

0.536

High

867185

KPCZ
Protein kinase C zeta type

1

1

High-throughput

0.536

High

867187

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

867198

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

3

High-throughput

0.536

High

867204

FL2D
Pre-mRNA-splicing regulator WTAP

1

1

High-throughput

0.536

High

867212

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

867230

MINK1
Misshapen-like kinase 1

1

1

High-throughput

0.536

High

867246

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

1

High-throughput

0.536

High

867250

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

867269

KS6B2
Ribosomal protein S6 kinase beta-2

1

1

High-throughput

0.536

High

197891

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

0

High-throughput

0.513

High

201278

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

242399

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

High-throughput

0.513

High

281194

RL1D1
Ribosomal L1 domain-containing protein 1

1

0

High-throughput

0.513

High

328781

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.513

High

337407

ABL1
Tyrosine-protein kinase ABL1

1

0

High-throughput

0.513

High

362967

FINC
Fibronectin

1

0

High-throughput

0.513

High

403133

LA
Lupus La protein

1

0

High-throughput

0.513

High

452692

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

528825

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

540938

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

0

High-throughput

0.513

High

543007

GLNA
Glutamine synthetase

1

0

High-throughput

0.513

High

790719

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.513

High

805888

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

834697

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.513

High

845914

RB27A
Ras-related protein Rab-27A

1

0

High-throughput

0.513

High

867186

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.513

High

867191

ILF3
Interleukin enhancer-binding factor 3

1

0

High-throughput

0.513

High

867195

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

0

High-throughput

0.513

High

867202

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.513

High

867210

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.513

High

867222

COMD6
COMM domain-containing protein 6

1

0

High-throughput

0.513

High

867232

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.513

High

867236

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.513

High

867247

TRIB3
Tribbles homolog 3

1

0

High-throughput

0.513

High

867251

GNL3
Guanine nucleotide-binding protein-like 3

1

0

High-throughput

0.513

High

867253

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

867255

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.513

High

867256

SLK
STE20-like serine/threonine-protein kinase

1

0

High-throughput

0.513

High

867258

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.513

High

867261

NOP10
H/ACA ribonucleoprotein complex subunit 3

1

0

High-throughput

0.513

High

867262

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.513

High

867266

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

0

High-throughput

0.513

High

265974

PSIP1
PC4 and SFRS1-interacting protein

1

2

Small-scale

0.501

High

782505

HNF4A
Hepatocyte nuclear factor 4-alpha

1

1

Small-scale

0.501

High

867200

AAMP
Angio-associated migratory cell protein

1

2

High-throughput

0.489

High

394397

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

624827

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.480

High

676845

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

Small-scale

0.480

High

800324

CBX5
Chromobox protein homolog 5

1

0

Small-scale

0.480

High

867211

OBF1
POU domain class 2-associating factor 1

1

0

Small-scale

0.480

High

301697

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

331753

NSD2
Histone-lysine N-methyltransferase NSD2

1

1

Small-scale

0.479

High

346317

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

379163

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

501023

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.479

High

569453

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

683918

1433S
14-3-3 protein sigma

1

2

Small-scale

0.479

High

808422

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

823751

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

841107

CDK7
Cyclin-dependent kinase 7

1

3

High-throughput

0.479

High

867171

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

867173

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

867175

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

867182

CDK5
Cyclin-dependent kinase 5

1

3

High-throughput

0.479

High

867183

SP3
Transcription factor Sp3

1

1

Small-scale

0.479

High

867184

1433F
14-3-3 protein eta

1

2

High-throughput

0.479

High

867193

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

867206

IRF4
Interferon regulatory factor 4

1

1

Small-scale

0.479

High

867208

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

867213

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.479

High

867223

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

867238

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

867240

H2B1H
Histone H2B type 1-H

1

2

High-throughput

0.479

High

867241

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

867254

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

867257

CLK4
Dual specificity protein kinase CLK4

1

1

High-throughput

0.479

High

867259

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

1

High-throughput

0.479

High

133394

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

239317

CC14B
Dual specificity protein phosphatase CDC14B

1

0

High-throughput

0.458

High

244165

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

263424

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

0

Small-scale

0.458

High

268429

BAF
Barrier-to-autointegration factor

1

0

Small-scale

0.458

High

298313

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

338176

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

450783

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

455256

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

499644

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

503746

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

523623

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

547485

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

552322

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

650765

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

720055

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

785786

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

832258

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

867172

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

867174

H4
Histone H4

1

0

High-throughput

0.458

High

867177

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.458

High

867178

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

867180

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.458

High

867181

H33
Histone H3.3

1

0

High-throughput

0.458

High

867190

TF3C1
General transcription factor 3C polypeptide 1

1

0

Small-scale

0.458

High

867192

FOXC1
Forkhead box protein C1

1

0

High-throughput

0.458

High

867199

CUL3
Cullin-3

1

0

High-throughput

0.458

High

867205

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

867207

TAF7
Transcription initiation factor TFIID subunit 7

1

0

Small-scale

0.458

High

867209

SEPT7
Septin-7

1

0

High-throughput

0.458

High

867215

TET2
Methylcytosine dioxygenase TET2

1

0

Small-scale

0.458

High

867216

TEN4
Teneurin-4

1

0

High-throughput

0.458

High

867224

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

867225

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

867228

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

867235

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

867237

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

867239

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.458

High

867242

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.458

High

867243

OPTN
Optineurin

1

0

High-throughput

0.458

High

867245

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

867248

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.458

High

867249

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.458

High

867252

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

867263

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

867265

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

867272

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.458

High

867273

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.458

High

867274

FAN1
Fanconi-associated nuclease 1

1

0

High-throughput

0.458

High

867276

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

551097

ITF2
Transcription factor 4

1

1

High-throughput

0.445

High

867234

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.437

High

496631

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

717595

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

867188

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.426

High

867197

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

867220

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.426

High

867217

Q6NSK7
RIN3 protein

1

2

High-throughput

0.417

High

831138

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

330925

PAK4
Serine/threonine-protein kinase PAK 4

2

0

High-throughput

0.313

High

867268

RHG20
Rho GTPase-activating protein 20

2

0

High-throughput

0.298

High

128502

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.279

Low

867214

CSCL2
CSC1-like protein 2

1

0

High-throughput

0.279

Low

867226

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.279

Low

867227

MYLK4
Myosin light chain kinase family member 4

1

0

High-throughput

0.279

Low

867229

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.279

Low

867260

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.279

Low

867264

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.279

Low

867267

PIM2
Serine/threonine-protein kinase pim-2

1

0

High-throughput

0.279

Low

867196

PTK7
Inactive tyrosine-protein kinase 7

1

0

High-throughput

0.269

Low

657318

ABCD3
ATP-binding cassette sub-family D member 3

1

0

High-throughput

0.268

Low

867219

PBIR3
PABIR family member 1

1

0

High-throughput

0.268

Low

124805

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

Small-scale

0.249

Low

390796

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

867170

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.249

Low

867203

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

867218

SCYL2
SCY1-like protein 2

1

0

High-throughput

0.249

Low

867221

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

867231

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

867233

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

867270

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.249

Low

867275

SHLB1
Endophilin-B1

1

0

High-throughput

0.249

Low

255081

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.232

Low

267388

ECI2
Enoyl-CoA delta isomerase 2

1

0

High-throughput

0.232

Low

867201

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024