HitPredict

Interactor 1: Q95SH2 (Q95SH2)
Charged multivesicular body protein 1, isoform A (Charged multivesicular body protein 1, isoform B) (GH26351p)
Gene: Chmp1

Interactor 2: Q9VBI3 (Q9VBI3)
RH72336p (Vacuolar protein sorting 2)
Gene: Vps2

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Snf7~Snf7
Common GO terms	GO:0000815 - ESCRT III complex GO:0015031 - protein transport GO:0032509 - endosome transport via multivesicular body sorting pathway GO:0045324 - late endosome to vacuole transport
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 203 Dm			1 256
+	Dm
		1469211 Q9VRJ5_DROME (4-202): 2.12e-39: 136: 19.10		Q9VBI3_DROME (1-256): 2.33e-43: 149: 100.00
+	At
		1082300 CHM1A_ARATH (2-200): 1.09e-40: 138: 43.72		VPS2B_ARATH (3-213): 2.37e-38: 135: 31.82
+	At
		1082317 VPS2A_ARATH (3-201): 7.18e-40: 137: 23.59		VPS2B_ARATH (3-213): 2.37e-38: 135: 31.82
+	Hs
		221896 CHMP3_HUMAN (4-201): 2.42e-36: 128: 16.27		CHM2A_HUMAN (1-190): 1.62e-41: 143: 77.90
+	Sc
		781314 DID4_YEAST (4-201): 3.93e-36: 127: 22.33		DID4_YEAST (2-256): 6.38e-41: 142: 39.45
+	Hs
		1462769 CHMP3_HUMAN (4-201): 2.42e-36: 128: 16.27		CHM2B_HUMAN (7-212): 4.1e-40: 139: 33.50
+	At
		1082319 CHM1B_ARATH (2-200): 3.1e-37: 129: 43.72		VPS2B_ARATH (3-213): 2.37e-38: 135: 31.82
+	Hs
		1491233 CHMP3_HUMAN (4-201): 2.42e-36: 128: 16.27		CHMP3_HUMAN (4-194): 7.45e-39: 136: 23.83
+	Dm
		1482281 Q9VRJ5_DROME (4-202): 2.12e-39: 136: 19.10		Q9VN02_DROME (4-208): 7.13e-35: 126: 23.19
+	Dm
		1377977 Q9VRJ5_DROME (4-202): 2.12e-39: 136: 19.10		Q95SH2_DROME (14-215): 1.39e-34: 124: 26.73
+	At
		1424668 VPS2A_ARATH (3-201): 7.18e-40: 137: 23.59		VP241_ARATH (3-209): 2.63e-33: 122: 25.12
+	Dm
		1484931 Q9VRJ5_DROME (4-202): 2.12e-39: 136: 19.10		CHMP5_DROME (1-206): 1.7e-33: 123: 18.31
+	Dm
		1377975 Q95SH2_DROME (1-203): 5.12e-38: 132: 100.00		Q9VN02_DROME (4-208): 7.13e-35: 126: 23.19
+	Hs
		1453653 CHMP3_HUMAN (4-201): 2.42e-36: 128: 16.27		CHMP5_HUMAN (1-203): 2.24e-36: 129: 19.05
+	Dm
		1377979 Q95SH2_DROME (1-203): 5.12e-38: 132: 100.00		CHMP5_DROME (1-206): 1.7e-33: 123: 18.31
+	Hs
		1439653 CHMP3_HUMAN (4-201): 2.42e-36: 128: 16.27		CHM1A_HUMAN (15-212): 1.26e-31: 117: 19.19
+	Sc
		781005 DID4_YEAST (4-201): 3.93e-36: 127: 22.33		VPS24_YEAST (8-208): 8.55e-32: 118: 19.31
+	Hs
		1273187 CHMP3_HUMAN (4-201): 2.42e-36: 128: 16.27		CHM1B_HUMAN (15-208): 9.58e-31: 114: 26.29
+	Ce
		1166323 Q9U2F6_CAEEL (3-187): 2.95e-38: 133: 24.87		Q18886_CAEEL (2-206): 2.46e-27: 106: 19.73