Protein: TLX1
T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)

Gene: TLX1
Organism: Homo sapiens
Interactions: 174
UniProt ID: P31314

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

129968

MEIS1
Homeobox protein Meis1

2

20

Small-scale

0.783

High

154467

MEIS2
Homeobox protein Meis2

2

20

Small-scale

0.783

High

679068

PBX2
Pre-B-cell leukemia transcription factor 2

2

20

Small-scale

0.757

High

679067

PBX1
Pre-B-cell leukemia transcription factor 1

1

20

Small-scale

0.653

High

679064

TLX1
T-cell leukemia homeobox protein 1

1

16

Small-scale

0.647

High

679065

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

7

Small-scale

0.629

High

679096

TLE1
Transducin-like enhancer protein 1

2

20

Small-scale

0.624

High

567816

HXB9
Homeobox protein Hox-B9

1

18

High-throughput

0.618

High

679066

CUX1
Homeobox protein cut-like 1

1

20

High-throughput

0.618

High

679073

MNX1
Motor neuron and pancreas homeobox protein 1

1

18

High-throughput

0.618

High

679095

SATB1
DNA-binding protein SATB1

1

7

High-throughput

0.618

High

679107

MEF2D
Myocyte-specific enhancer factor 2D

1

1

High-throughput

0.618

High

679110

ZFHX3
Zinc finger homeobox protein 3

1

12

High-throughput

0.618

High

679132

ZFHX4
Zinc finger homeobox protein 4

1

16

High-throughput

0.618

High

679187

SIX4
Homeobox protein SIX4

1

20

High-throughput

0.618

High

679192

SATB2
DNA-binding protein SATB2

1

7

High-throughput

0.618

High

679069

PBX3
Pre-B-cell leukemia transcription factor 3

1

20

Small-scale

0.590

High

679081

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

7

Small-scale

0.573

High

679084

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

8

Small-scale

0.573

High

586585

CSK22
Casein kinase II subunit alpha'

1

14

High-throughput

0.536

High

679099

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.536

High

416937

IF4E
Eukaryotic translation initiation factor 4E

1

4

Small-scale

0.501

High

128041

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

6

High-throughput

0.500

High

403094

LA
Lupus La protein

1

1

High-throughput

0.500

High

518590

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.500

High

523542

XRCC6
X-ray repair cross-complementing protein 6

1

12

High-throughput

0.500

High

524803

XRCC5
X-ray repair cross-complementing protein 5

1

12

High-throughput

0.500

High

650463

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.500

High

679072

DNLI3
DNA ligase 3

1

3

High-throughput

0.500

High

679079

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.500

High

679085

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.500

High

679087

CSK21
Casein kinase II subunit alpha

1

8

High-throughput

0.500

High

679093

TFAM
Transcription factor A, mitochondrial

1

20

High-throughput

0.500

High

679123

UBN2
Ubinuclein-2

1

20

High-throughput

0.500

High

679126

DHX30
ATP-dependent RNA helicase DHX30

1

4

High-throughput

0.500

High

679170

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.500

High

679181

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

6

High-throughput

0.500

High

445292

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.479

High

679077

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.479

High

679082

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.479

High

679083

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.479

High

679117

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.479

High

135082

NFIB
Nuclear factor 1 B-type

1

14

High-throughput

0.479

High

146163

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

152596

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

164190

ZN609
Zinc finger protein 609

1

19

High-throughput

0.479

High

167140

ZN536
Zinc finger protein 536

1

12

High-throughput

0.479

High

183070

KDM6A
Lysine-specific demethylase 6A

1

7

High-throughput

0.479

High

231209

ZEB2
Zinc finger E-box-binding homeobox 2

1

7

High-throughput

0.479

High

245566

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

11

High-throughput

0.479

High

260360

ZN217
Zinc finger protein 217

1

7

High-throughput

0.479

High

261413

NCOR1
Nuclear receptor corepressor 1

1

20

High-throughput

0.479

High

277947

PIAS1
E3 SUMO-protein ligase PIAS1

1

5

High-throughput

0.479

High

318579

EYA4
Eyes absent homolog 4

1

17

High-throughput

0.479

High

321714

WIZ
Protein Wiz

1

8

High-throughput

0.479

High

443136

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

473475

ATX1L
Ataxin-1-like

1

5

High-throughput

0.479

High

525285

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

20

High-throughput

0.479

High

541985

ETS1
Protein C-ets-1

1

17

Small-scale

0.479

High

550324

ZEP1
Zinc finger protein 40

1

6

High-throughput

0.479

High

679075

SMCA2
Probable global transcription activator SNF2L2

1

20

High-throughput

0.479

High

679076

ATN1
Atrophin-1

1

17

High-throughput

0.479

High

679078

DCAF7
DDB1- and CUL4-associated factor 7

1

12

High-throughput

0.479

High

679088

SSBP2
Single-stranded DNA-binding protein 2

1

5

High-throughput

0.479

High

679092

FOXK1
Forkhead box protein K1

1

20

High-throughput

0.479

High

679094

TFAP4
Transcription factor AP-4

1

1

High-throughput

0.479

High

679097

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

679098

TLE4
Transducin-like enhancer protein 4

1

20

High-throughput

0.479

High

679100

RING1
E3 ubiquitin-protein ligase RING1

1

19

High-throughput

0.479

High

679101

TLE5
TLE family member 5

1

20

High-throughput

0.479

High

679102

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

679103

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.479

High

679104

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

679105

FOXC1
Forkhead box protein C1

1

20

High-throughput

0.479

High

679108

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

1

Small-scale

0.479

High

679109

NCOA2
Nuclear receptor coactivator 2

1

15

High-throughput

0.479

High

679113

ZN260
Zinc finger protein 260

1

1

High-throughput

0.479

High

679114

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

679115

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

High-throughput

0.479

High

679119

NIPBL
Nipped-B-like protein

1

13

High-throughput

0.479

High

679121

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

20

High-throughput

0.479

High

679122

BCOR
BCL-6 corepressor

1

20

High-throughput

0.479

High

679124

PAXI1
PAX-interacting protein 1

1

17

High-throughput

0.479

High

679127

POGZ
Pogo transposable element with ZNF domain

1

8

High-throughput

0.479

High

679128

I2BP2
Interferon regulatory factor 2-binding protein 2

1

1

High-throughput

0.479

High

679129

PCGF5
Polycomb group RING finger protein 5

1

20

High-throughput

0.479

High

679130

LDB1
LIM domain-binding protein 1

1

7

High-throughput

0.479

High

679131

PB1
Protein polybromo-1

1

19

High-throughput

0.479

High

679133

I2BP1
Interferon regulatory factor 2-binding protein 1

1

1

High-throughput

0.479

High

679134

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

679135

ARI3B
AT-rich interactive domain-containing protein 3B

1

20

High-throughput

0.479

High

679136

HOMEZ
Homeobox and leucine zipper protein Homez

1

20

High-throughput

0.479

High

679137

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

679138

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

679139

KDM2B
Lysine-specific demethylase 2B

1

5

High-throughput

0.479

High

679140

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

2

High-throughput

0.479

High

679141

AUTS2
Autism susceptibility gene 2 protein

1

20

High-throughput

0.479

High

679144

MAML1
Mastermind-like protein 1

1

20

High-throughput

0.479

High

679145

ZN516
Zinc finger protein 516

1

10

High-throughput

0.479

High

679146

RREB1
Ras-responsive element-binding protein 1

1

3

High-throughput

0.479

High

679147

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

679148

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

679149

CBP
CREB-binding protein

1

20

High-throughput

0.479

High

679150

KAT6A
Histone acetyltransferase KAT6A

1

20

High-throughput

0.479

High

679151

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

High-throughput

0.479

High

679152

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

7

High-throughput

0.479

High

679153

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

1

4

High-throughput

0.479

High

679154

ZN503
Zinc finger protein 503

1

6

High-throughput

0.479

High

679155

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

3

High-throughput

0.479

High

679156

ZN462
Zinc finger protein 462

1

3

High-throughput

0.479

High

679157

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

20

High-throughput

0.479

High

679158

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

679160

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

679161

EYA3
Eyes absent homolog 3

1

4

High-throughput

0.479

High

679162

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

679164

PCGF1
Polycomb group RING finger protein 1

1

19

High-throughput

0.479

High

679166

SSBP3
Single-stranded DNA-binding protein 3

1

10

High-throughput

0.479

High

679167

SP130
Histone deacetylase complex subunit SAP130

1

15

High-throughput

0.479

High

679168

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

4

High-throughput

0.479

High

679169

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.479

High

679171

ZN644
Zinc finger protein 644

1

13

High-throughput

0.479

High

679172

ZN703
Zinc finger protein 703

1

16

High-throughput

0.479

High

679173

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

20

High-throughput

0.479

High

679176

SHCAF
SIN3-HDAC complex-associated factor

1

3

High-throughput

0.479

High

679177

HM20A
High mobility group protein 20A

1

20

High-throughput

0.479

High

679178

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

679179

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.479

High

679180

SALL1
Sal-like protein 1

1

18

High-throughput

0.479

High

679182

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

15

High-throughput

0.479

High

679183

RCOR3
REST corepressor 3

1

20

High-throughput

0.479

High

679184

TCF20
Transcription factor 20

1

20

High-throughput

0.479

High

679185

TRPS1
Zinc finger transcription factor Trps1

1

14

High-throughput

0.479

High

679188

RCOR1
REST corepressor 1

1

20

High-throughput

0.479

High

679189

ZN608
Zinc finger protein 608

1

9

High-throughput

0.479

High

679190

PRR12
Proline-rich protein 12

1

20

High-throughput

0.479

High

679193

SMC3
Structural maintenance of chromosomes protein 3

1

5

High-throughput

0.479

High

679196

ZN281
Zinc finger protein 281

1

9

High-throughput

0.479

High

679199

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

4

High-throughput

0.479

High

679200

NCOR2
Nuclear receptor corepressor 2

1

20

High-throughput

0.479

High

679202

NCOA3
Nuclear receptor coactivator 3

1

15

High-throughput

0.479

High

679120

LIN54
Protein lin-54 homolog

1

0

High-throughput

0.458

High

679143

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

679165

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

High-throughput

0.458

High

679186

DACH1
Dachshund homolog 1

1

0

High-throughput

0.458

High

216458

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

6

High-throughput

0.457

High

451197

TPM1
Tropomyosin alpha-1 chain

1

3

High-throughput

0.457

High

679074

EMD
Emerin

1

3

High-throughput

0.457

High

679086

TPM4
Tropomyosin alpha-4 chain

1

2

High-throughput

0.457

High

679089

RT22
Small ribosomal subunit protein mS22

1

3

High-throughput

0.457

High

679090

RT09
Small ribosomal subunit protein uS9m

1

2

High-throughput

0.457

High

679116

RRP12
RRP12-like protein

1

3

High-throughput

0.457

High

679142

RT27
Small ribosomal subunit protein mS27

1

2

High-throughput

0.457

High

679191

G3BP2
Ras GTPase-activating protein-binding protein 2

1

1

High-throughput

0.457

High

679194

RT28
Small ribosomal subunit protein bS1m

1

1

High-throughput

0.457

High

679195

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.457

High

679197

RT23
Small ribosomal subunit protein mS23

1

2

High-throughput

0.457

High

679201

RT18B
Small ribosomal subunit protein mS40

1

2

High-throughput

0.457

High

131695

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.437

High

679106

GSE1
Genetic suppressor element 1

1

2

High-throughput

0.437

High

679112

QSER1
Glutamine and serine-rich protein 1

1

20

High-throughput

0.437

High

679118

ZMYM4
Zinc finger MYM-type protein 4

1

4

High-throughput

0.437

High

679125

ASXL2
Putative Polycomb group protein ASXL2

1

9

High-throughput

0.437

High

679163

PYGO2
Pygopus homolog 2

1

3

High-throughput

0.437

High

679174

FBRS
Probable fibrosin-1

1

8

High-throughput

0.437

High

679175

FBSL
Fibrosin-1-like protein

1

8

High-throughput

0.437

High

679198

PYGO1
Pygopus homolog 1

1

15

High-throughput

0.437

High

679111

CTF1
Cardiotrophin-1

1

0

Small-scale

0.261

Low

240955

RT14
Small ribosomal subunit protein uS14m

1

0

High-throughput

0.261

Low

679070

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.261

Low

679071

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.261

Low

679080

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.261

Low

679159

PEO1
Twinkle mtDNA helicase

1

0

High-throughput

0.261

Low

679091

RL36A
Large ribosomal subunit protein eL42

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024