Protein: RFX6
DNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1)

Gene: RFX6
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q8HWS3

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

574357

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

4

0

High-throughput

0.673

High

871755

RFX2
DNA-binding protein RFX2

3

9

High-throughput

0.667

High

1127355

CASL
Enhancer of filamentation 1

3

0

High-throughput

0.646

High

274018

CREST
Calcium-responsive transactivator

3

0

High-throughput

0.639

High

750441

CSTF2
Cleavage stimulation factor subunit 2

2

1

High-throughput

0.606

High

1301004

TEKT4
Tektin-4

2

1

High-throughput

0.606

High

1301008

TEKT3
Tektin-3

2

1

High-throughput

0.606

High

1289227

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

1

High-throughput

0.590

High

1301006

TET5B
Terminal nucleotidyltransferase 5B

2

0

High-throughput

0.580

High

1301009

DUS21
Dual specificity protein phosphatase 21

2

0

High-throughput

0.580

High

1301010

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

2

0

High-throughput

0.580

High

1301012

DMRT3
Doublesex- and mab-3-related transcription factor 3

2

0

High-throughput

0.580

High

1301014

MEMO1
Protein MEMO1

2

0

High-throughput

0.580

High

930743

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.573

High

1095404

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

High-throughput

0.573

High

291830

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.549

High

1061762

TLE5
TLE family member 5

1

0

High-throughput

0.549

High

871788

RFX3
Transcription factor RFX3

1

9

High-throughput

0.541

High

1005611

PITX1
Pituitary homeobox 1

1

1

High-throughput

0.541

High

1116525

FHL3
Four and a half LIM domains protein 3

1

3

High-throughput

0.541

High

1301005

ESR2
Estrogen receptor beta

1

3

High-throughput

0.541

High

1301011

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

2

High-throughput

0.541

High

1193118

PKHN1
Pleckstrin homology domain-containing family N member 1

1

1

High-throughput

0.523

High

297007

CCNK
Cyclin-K

1

0

High-throughput

0.518

High

1301003

LMO3
LIM domain only protein 3

1

0

High-throughput

0.518

High

1301015

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

0

High-throughput

0.518

High

169636

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

High-throughput

0.494

High

480211

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.481

High

505734

ZN688
Zinc finger protein 688

1

1

High-throughput

0.481

High

1120862

DGCR6
Protein DGCR6

1

1

High-throughput

0.481

High

1301013

OCAD1
OCIA domain-containing protein 1

1

2

High-throughput

0.470

High

1215272

Q5TAL4
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.470

High

1301017

X5DP31
Aryl hydrocarbon receptor nuclear translocator 2

1

2

High-throughput

0.457

High

3386

A0A0S2Z4Q4
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

High-throughput

0.417

High

3550

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

1

High-throughput

0.417

High

1301016

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

1

High-throughput

0.417

High

220268

FRS3
Fibroblast growth factor receptor substrate 3

3

0

High-throughput

0.352

High

1301002

CTSR1
Cation channel sperm-associated protein 1

3

0

High-throughput

0.352

High

288459

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

0

High-throughput

0.316

High

638855

AGT1
Alanine--glyoxylate aminotransferase

2

0

High-throughput

0.316

High

940784

LEG4
Galectin-4

2

0

High-throughput

0.316

High

1271367

KCTD9
BTB/POZ domain-containing protein KCTD9

2

0

High-throughput

0.316

High

1279447

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.316

High

1301007

ZMY19
Zinc finger MYND domain-containing protein 19

2

0

High-throughput

0.316

High

63226

VP37C
Vacuolar protein sorting-associated protein 37C

1

0

High-throughput

0.299

High

1085090

KIF1A
Kinesin-like protein KIF1A

1

0

High-throughput

0.282

High

1272173

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

0

High-throughput

0.282

High

955350

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025