Protein: UBP33
Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)

Gene: UBP33, USP33
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q8TEY7

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476097

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.778

High

228159

PRKN
E3 ubiquitin-protein ligase parkin

1

20

Small-scale

0.747

High

686017

ARRB2
Beta-arrestin-2

4

4

Small-scale

0.707

High

1257050

ROBO1
Roundabout homolog 1

4

2

Small-scale

0.683

High

199937

SPIT2
Kunitz-type protease inhibitor 2

3

6

High-throughput

0.667

High

310736

VAPB
Vesicle-associated membrane protein-associated protein B/C

3

6

High-throughput

0.667

High

1257031

STN1
CST complex subunit STN1

3

2

High-throughput

0.667

High

772077

VHL
von Hippel-Lindau disease tumor suppressor

2

2

Small-scale

0.654

High

1257019

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

19

High-throughput

0.647

High

1257044

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

19

High-throughput

0.647

High

1257047

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

17

High-throughput

0.647

High

1257022

CGRF1
Cell growth regulator with RING finger domain protein 1

3

0

High-throughput

0.638

High

429091

ADRB2
Beta-2 adrenergic receptor

3

3

Small-scale

0.633

High

237507

TLR2
Toll-like receptor 2

2

2

High-throughput

0.628

High

1257004

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

7

High-throughput

0.628

High

1257023

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

2

4

High-throughput

0.628

High

1257026

PCGF6
Polycomb group RING finger protein 6

2

20

High-throughput

0.628

High

1257028

TKTL2
Transketolase-like protein 2

2

4

High-throughput

0.628

High

1257043

VAPA
Vesicle-associated membrane protein-associated protein A

2

6

High-throughput

0.628

High

1072394

ELOB
Elongin-B

1

1

Small-scale

0.618

High

1257045

FBW1A
F-box/WD repeat-containing protein 1A

1

10

Small-scale

0.618

High

1257046

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

18

Small-scale

0.618

High

1257007

IOD2
Type II iodothyronine deiodinase

3

1

Small-scale

0.616

High

885449

VSX2
Visual system homeobox 2

3

5

High-throughput

0.609

High

1074520

SP17
Sperm surface protein Sp17

2

0

High-throughput

0.585

High

717228

CTNB1
Catenin beta-1

2

20

Small-scale

0.584

High

890292

SC61B
Protein transport protein Sec61 subunit beta

2

1

High-throughput

0.584

High

338741

EGFR
Epidermal growth factor receptor

1

10

Small-scale

0.582

High

1028257

SBP1
Methanethiol oxidase

1

1

Small-scale

0.573

High

1072255

ELOC
Elongin-C

2

0

Small-scale

0.569

High

200634

CP110
Centriolar coiled-coil protein of 110 kDa

1

1

Small-scale

0.561

High

506408

RALA
Ras-related protein Ral-A

1

10

Small-scale

0.552

High

506467

RALB
Ras-related protein Ral-B

1

10

Small-scale

0.552

High

1257041

DDX56
Probable ATP-dependent RNA helicase DDX56

1

14

High-throughput

0.541

High

271973

CTAG2
Cancer/testis antigen 2

1

1

High-throughput

0.536

High

1031238

SKP2
S-phase kinase-associated protein 2

1

3

High-throughput

0.536

High

1167725

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

6

High-throughput

0.536

High

1189613

K1C27
Keratin, type I cytoskeletal 27

1

14

High-throughput

0.536

High

1257003

CT55
Cancer/testis antigen 55

1

1

High-throughput

0.536

High

1257009

SPSB4
SPRY domain-containing SOCS box protein 4

1

20

High-throughput

0.536

High

1257013

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.536

High

1257032

TM134
Transmembrane protein 134

1

1

High-throughput

0.536

High

1031826

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

2

High-throughput

0.515

High

1040628

KRR1
KRR1 small subunit processome component homolog

1

2

High-throughput

0.515

High

1257017

ZFR
Zinc finger RNA-binding protein

1

7

High-throughput

0.515

High

351179

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.513

High

621555

IL32
Interleukin-32

1

0

High-throughput

0.513

High

1018904

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

0

High-throughput

0.513

High

1257008

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.501

High

1257027

TRI54
Tripartite motif-containing protein 54

1

20

High-throughput

0.501

High

445789

ACM5
Muscarinic acetylcholine receptor M5

1

6

High-throughput

0.494

High

259504

LRRN2
Leucine-rich repeat neuronal protein 2

1

5

High-throughput

0.489

High

558763

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

2

High-throughput

0.489

High

577442

GBRG2
Gamma-aminobutyric acid receptor subunit gamma-2

1

1

High-throughput

0.489

High

1031027

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

4

High-throughput

0.489

High

1037185

TRPC3
Short transient receptor potential channel 3

1

2

High-throughput

0.489

High

1199482

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

6

High-throughput

0.489

High

1257020

CRML
Protein cramped-like

1

1

High-throughput

0.489

High

1257030

TMX1
Thioredoxin-related transmembrane protein 1

1

7

High-throughput

0.489

High

1257034

RXFP1
Relaxin receptor 1

1

7

High-throughput

0.489

High

1257040

ASIC5
Acid-sensing ion channel 5

1

6

High-throughput

0.489

High

160680

AURKA
Aurora kinase A

1

19

Small-scale

0.479

High

163898

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

6

High-throughput

0.479

High

273910

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.479

High

319940

HERC2
E3 ubiquitin-protein ligase HERC2

1

16

Small-scale

0.479

High

347416

MYC
Myc proto-oncogene protein

1

18

Small-scale

0.479

High

348819

RASN
GTPase NRas

1

10

High-throughput

0.479

High

350387

RASK
GTPase KRas

1

9

High-throughput

0.479

High

360201

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

17

High-throughput

0.479

High

390404

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

436427

RHOC
Rho-related GTP-binding protein RhoC

1

6

High-throughput

0.479

High

444763

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

10

High-throughput

0.479

High

592398

RAB5A
Ras-related protein Rab-5A

1

5

High-throughput

0.479

High

659305

DUS1
Dual specificity protein phosphatase 1

1

7

Small-scale

0.479

High

681948

AKT1
RAC-alpha serine/threonine-protein kinase

1

8

Small-scale

0.479

High

736275

ARRC
Arrestin-C

1

4

Small-scale

0.479

High

786037

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

814286

GLR
Glucagon receptor

1

1

Small-scale

0.479

High

827251

ARRB1
Beta-arrestin-1

1

4

Small-scale

0.479

High

839008

EMD
Emerin

1

1

High-throughput

0.479

High

845105

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.479

High

900729

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

990572

CKAP4
Cytoskeleton-associated protein 4

1

20

High-throughput

0.479

High

1017727

STX4
Syntaxin-4

1

2

High-throughput

0.479

High

1042126

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1054169

BECN1
Beclin-1

1

2

Small-scale

0.479

High

1088424

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

1

5

Small-scale

0.479

High

1240221

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.479

High

1240696

RN149
E3 ubiquitin-protein ligase RNF149

1

8

High-throughput

0.479

High

1257006

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.479

High

1257011

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.479

High

1257014

NEUL4
Neuralized-like protein 4

1

3

Small-scale

0.479

High

1257016

EXOC2
Exocyst complex component 2

1

1

Small-scale

0.479

High

1257018

SNX27
Sorting nexin-27

1

11

High-throughput

0.479

High

1257024

EPAS1
Endothelial PAS domain-containing protein 1

1

9

Small-scale

0.479

High

1257038

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.479

High

1257042

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.479

High

1257048

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

1138134

PR38B
Pre-mRNA-splicing factor 38B

1

1

High-throughput

0.470

High

880980

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.460

High

847575

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

1188321

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1257005

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.458

High

1257033

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1257035

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1257039

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1032252

CENPR
Centromere protein R

1

1

High-throughput

0.457

High

1257037

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.457

High

170556

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

1

1

High-throughput

0.437

High

723741

DRD3
D(3) dopamine receptor

1

4

Small-scale

0.437

High

795212

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.437

High

1040181

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.437

High

1230295

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.437

High

1257015

DNJC1
DnaJ homolog subfamily C member 1

1

11

High-throughput

0.437

High

1257021

SEC62
Translocation protein SEC62

1

1

High-throughput

0.437

High

1257025

DERL1
Derlin-1

1

2

High-throughput

0.437

High

886311

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

1145408

LPCT4
Lysophospholipid acyltransferase LPCAT4

2

0

High-throughput

0.328

High

1125075

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1224487

MCLN2
Mucolipin-2

1

0

High-throughput

0.279

Low

1257012

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

132544

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

179445

MPPD1
Metallophosphoesterase domain-containing protein 1

1

0

High-throughput

0.249

Low

391047

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

1257010

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1257029

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

1257036

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1257049

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low

1139846

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024