Protein: GDF5
Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)

Gene: GDF5
Organism: Homo sapiens
Interactions: 37
UniProt ID: P43026

Gene Ontology (top 5):
GO:0002062 - chondrocyte differentiation
GO:0005125 - cytokine activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

787118

BMR1A
Bone morphogenetic protein receptor type-1A

4

20

Small-scale

0.888

High

128529

BMR1B
Bone morphogenetic protein receptor type-1B

3

20

Small-scale

0.858

High

845235

BMPR2
Bone morphogenetic protein receptor type-2

3

20

Small-scale

0.840

High

845240

LRC15
Leucine-rich repeat-containing protein 15

2

0

High-throughput

0.770

High

845226

GDF5
Growth/differentiation factor 5

1

15

Small-scale

0.647

High

845233

NOGG
Noggin

1

2

Small-scale

0.647

High

289244

SPB7
Serpin B7

2

8

High-throughput

0.628

High

424489

PAI2
Plasminogen activator inhibitor 2

2

8

High-throughput

0.628

High

787617

SPB5
Serpin B5

2

8

High-throughput

0.628

High

845244

CALL5
Calmodulin-like protein 5

2

2

High-throughput

0.628

High

845246

SPB13
Serpin B13

2

8

High-throughput

0.628

High

845247

PKP3
Plakophilin-3

2

3

High-throughput

0.628

High

690076

AVR2A
Activin receptor type-2A

1

20

Small-scale

0.618

High

845231

ACVR1
Activin receptor type-1

1

20

Small-scale

0.618

High

845234

AVR2B
Activin receptor type-2B

1

20

Small-scale

0.618

High

845228

PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

2

0

High-throughput

0.602

High

845232

SBP1
Methanethiol oxidase

2

0

High-throughput

0.602

High

845238

TM102
Transmembrane protein 102

2

0

High-throughput

0.602

High

516650

VSIG8
V-set and immunoglobulin domain-containing protein 8

2

0

High-throughput

0.596

High

384638

CRYAB
Alpha-crystallin B chain

2

1

High-throughput

0.574

High

578614

FABP4
Fatty acid-binding protein, adipocyte

2

2

High-throughput

0.574

High

711691

RABP2
Cellular retinoic acid-binding protein 2

2

2

High-throughput

0.574

High

845239

R3GEF
Guanine nucleotide exchange factor for Rab-3A

2

1

High-throughput

0.574

High

845242

RAB3I
Rab-3A-interacting protein

2

1

High-throughput

0.574

High

845230

TSG6
Tumor necrosis factor-inducible gene 6 protein

1

16

Small-scale

0.536

High

845227

LEG7
Galectin-7

1

0

High-throughput

0.513

High

692664

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.489

High

845236

TRI29
Tripartite motif-containing protein 29

1

4

High-throughput

0.489

High

612920

EGR1
Early growth response protein 1

1

3

High-throughput

0.479

High

283040

PSIP1
PC4 and SFRS1-interacting protein

1

1

High-throughput

0.470

High

845229

CTBP2
C-terminal-binding protein 2

1

2

High-throughput

0.437

High

845241

WNK4
Serine/threonine-protein kinase WNK4

1

1

High-throughput

0.437

High

845245

KS6B2
Ribosomal protein S6 kinase beta-2

1

1

High-throughput

0.437

High

326675

DUS14
Dual specificity protein phosphatase 14

2

0

High-throughput

0.328

High

845237

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.328

High

845243

SNRK
SNF-related serine/threonine-protein kinase

2

0

High-throughput

0.328

High


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Last updated: 11Aug2025