Protein: RBL1
Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)

Gene: RBL1
Organism: Homo sapiens
Interactions: 116
UniProt ID: P28749

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

660145

E2F4
Transcription factor E2F4

11

20

Small-scale

0.970

High

660118

E2F1
Transcription factor E2F1

9

20

Small-scale

0.967

High

660137

TFDP2
Transcription factor Dp-2

2

11

Small-scale

0.802

High

625138

CDK2
Cyclin-dependent kinase 2

13

9

Small-scale

0.762

High

135214

E2F3
Transcription factor E2F3

2

20

Small-scale

0.754

High

660124

RBL2
Retinoblastoma-like protein 2

2

2

Small-scale

0.754

High

590128

CCNA2
Cyclin-A2

8

7

Small-scale

0.748

High

660129

CTBP1
C-terminal-binding protein 1

3

2

High-throughput

0.667

High

660136

TFDP1
Transcription factor Dp-1

1

11

Small-scale

0.665

High

486873

MYBB
Myb-related protein B

3

4

Small-scale

0.664

High

660135

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

14

High-throughput

0.657

High

660172

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

14

High-throughput

0.657

High

660148

LIN9
Protein lin-9 homolog

3

5

Small-scale

0.656

High

660152

CC062
Uncharacterized protein C3orf62

3

1

High-throughput

0.650

High

660131

HDAC1
Histone deacetylase 1

2

12

Small-scale

0.641

High

660094

PHB1
Prohibitin 1

2

2

Small-scale

0.624

High

660143

E2F5
Transcription factor E2F5

1

20

Small-scale

0.621

High

660138

E2F2
Transcription factor E2F2

1

20

Small-scale

0.618

High

660160

CTIP
DNA endonuclease RBBP8

2

3

Small-scale

0.613

High

660157

LIN37
Protein lin-37 homolog

2

3

Small-scale

0.611

High

660151

TXD11
Thioredoxin domain-containing protein 11

3

1

High-throughput

0.609

High

660140

IRF3
Interferon regulatory factor 3

1

2

High-throughput

0.586

High

515341

CDK4
Cyclin-dependent kinase 4

1

19

Small-scale

0.569

High

660117

CDK6
Cyclin-dependent kinase 6

1

20

Small-scale

0.569

High

660114

SMAD3
Mothers against decapentaplegic homolog 3

1

1

Small-scale

0.561

High

660127

TP53B
TP53-binding protein 1

1

1

Small-scale

0.561

High

660155

TF3B
Transcription factor IIIB 90 kDa subunit

1

3

Small-scale

0.561

High

660159

NEB2
Neurabin-2

1

2

Small-scale

0.561

High

206801

FOXO3
Forkhead box protein O3

1

9

High-throughput

0.554

High

660147

LIN52
Protein lin-52 homolog

1

3

Small-scale

0.550

High

586577

CSK22
Casein kinase II subunit alpha'

1

14

High-throughput

0.536

High

660106

DCAF7
DDB1- and CUL4-associated factor 7

1

13

High-throughput

0.536

High

660111

CSK21
Casein kinase II subunit alpha

1

12

High-throughput

0.536

High

660115

FOXK1
Forkhead box protein K1

1

7

High-throughput

0.536

High

660125

RBBP4
Histone-binding protein RBBP4

1

9

High-throughput

0.536

High

660161

CITE1
Cbp/p300-interacting transactivator 1

1

2

High-throughput

0.536

High

660110

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

6

Small-scale

0.512

High

660146

MK06
Mitogen-activated protein kinase 6

1

9

High-throughput

0.508

High

271827

CREG1
Protein CREG1

1

1

Small-scale

0.501

High

660092

KDM5A
Lysine-specific demethylase 5A

1

4

Small-scale

0.501

High

660093

MCM7
DNA replication licensing factor MCM7

1

2

Small-scale

0.501

High

660096

BRCA1
Breast cancer type 1 susceptibility protein

1

3

Small-scale

0.501

High

660112

CCNA1
Cyclin-A1

1

7

Small-scale

0.501

High

660132

SNW1
SNW domain-containing protein 1

1

2

Small-scale

0.501

High

660104

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.489

High

660116

CYC
Cytochrome c

1

1

High-throughput

0.489

High

660133

DGKZ
Diacylglycerol kinase zeta

1

5

Small-scale

0.488

High

611375

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

3

High-throughput

0.481

High

660102

SMCA4
Transcription activator BRG1

1

5

Small-scale

0.481

High

165632

SET1A
Histone-lysine N-methyltransferase SETD1A

1

9

Small-scale

0.479

High

177207

HDAC3
Histone deacetylase 3

1

12

Small-scale

0.479

High

203630

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

Small-scale

0.479

High

267907

EED
Polycomb protein EED

1

3

High-throughput

0.479

High

276966

RBBP9
Serine hydrolase RBBP9

1

4

Small-scale

0.479

High

346005

MYC
Myc proto-oncogene protein

1

2

Small-scale

0.479

High

434964

SP1
Transcription factor Sp1

1

2

Small-scale

0.479

High

487160

ANDR
Androgen receptor

1

3

Small-scale

0.479

High

552011

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

600086

TAF1
Transcription initiation factor TFIID subunit 1

1

6

Small-scale

0.479

High

624544

CCNE1
G1/S-specific cyclin-E1

1

12

Small-scale

0.479

High

650437

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

660090

EPHB2
Ephrin type-B receptor 2

1

2

High-throughput

0.479

High

660091

ARI4A
AT-rich interactive domain-containing protein 4A

1

6

Small-scale

0.479

High

660098

MAGAB
Melanoma-associated antigen 11

1

1

Small-scale

0.479

High

660099

CDN1C
Cyclin-dependent kinase inhibitor 1C

1

3

Small-scale

0.479

High

660101

CDK9
Cyclin-dependent kinase 9

1

17

High-throughput

0.479

High

660103

HCFC1
Host cell factor 1

1

1

Small-scale

0.479

High

660119

ID2
DNA-binding protein inhibitor ID-2

1

3

Small-scale

0.479

High

660126

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

660130

SMAD4
Mothers against decapentaplegic homolog 4

1

1

Small-scale

0.479

High

660134

CUL4A
Cullin-4A

1

2

High-throughput

0.479

High

660141

SUZ12
Polycomb protein SUZ12

1

2

Small-scale

0.479

High

660149

LIN54
Protein lin-54 homolog

1

5

Small-scale

0.479

High

660154

HDAC2
Histone deacetylase 2

1

12

Small-scale

0.479

High

660156

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

2

High-throughput

0.479

High

660164

NEK6
Serine/threonine-protein kinase Nek6

1

1

High-throughput

0.479

High

660166

NLE1
Notchless protein homolog 1

1

1

High-throughput

0.479

High

660167

AATF
Protein AATF

1

2

Small-scale

0.479

High

660170

PHF8
Histone lysine demethylase PHF8

1

1

Small-scale

0.479

High

660173

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

2

Small-scale

0.479

High

660176

MOFA1
MORF4 family-associated protein 1

1

2

High-throughput

0.479

High

170039

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.460

High

660107

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

High-throughput

0.460

High

313226

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

660095

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

660100

EMD
Emerin

1

0

Small-scale

0.458

High

660108

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.458

High

660113

NTH
Endonuclease III-like protein 1

1

0

High-throughput

0.458

High

660174

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

660128

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

Small-scale

0.457

High

660150

RINT1
RAD50-interacting protein 1

1

2

Small-scale

0.457

High

386154

P53
Cellular tumor antigen p53

1

3

High-throughput

0.445

High

256801

T22D2
TSC22 domain family protein 2

1

7

Small-scale

0.439

High

660089

EPHA2
Ephrin type-A receptor 2

1

2

High-throughput

0.439

High

660105

LAMB2
Laminin subunit beta-2

1

1

High-throughput

0.439

High

384324

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

660139

BECN1
Beclin-1

1

2

Small-scale

0.437

High

660142

CDK10
Cyclin-dependent kinase 10

1

11

High-throughput

0.437

High

660153

SNX19
Sorting nexin-19

1

2

Small-scale

0.437

High

660171

PA2G4
Proliferation-associated protein 2G4

1

2

Small-scale

0.437

High

660175

MARF1
Meiosis regulator and mRNA stability factor 1

1

1

High-throughput

0.437

High

508352

TOP1
DNA topoisomerase 1

1

1

Small-scale

0.408

High

660162

BEGIN
Brain-enriched guanylate kinase-associated protein

1

0

High-throughput

0.304

High

362852

FINC
Fibronectin

1

0

High-throughput

0.251

Low

660120

NUCB1
Nucleobindin-1

1

0

High-throughput

0.251

Low

660122

AOXA
Aldehyde oxidase

1

0

High-throughput

0.251

Low

660123

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.251

Low

660097

TSN7
Tetraspanin-7

1

0

High-throughput

0.249

Low

660109

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.249

Low

660121

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

0

Small-scale

0.249

Low

660144

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.249

Low

660163

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

660165

CD320
CD320 antigen

1

0

High-throughput

0.249

Low

660168

ARP3B
Actin-related protein 3B

1

0

High-throughput

0.249

Low

660169

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.249

Low

660158

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024