Protein: EPS8
Epidermal growth factor receptor kinase substrate 8

Gene: EPS8
Organism: Homo sapiens
Interactions: 113
UniProt ID: Q12929

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005886 - plasma membrane
GO:0005903 - brush border
GO:0005938 - cell cortex
GO:0007266 - Rho protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1090386

BAIP2
BAR/IMD domain-containing adapter protein 2

11

13

Small-scale

0.983

High

363204

EGFR
Epidermal growth factor receptor

5

20

Small-scale

0.925

High

1060674

SOS1
Son of sevenless homolog 1

4

20

Small-scale

0.873

High

1090353

ABI1
Abl interactor 1

3

20

Small-scale

0.857

High

1090330

EPS8
Epidermal growth factor receptor kinase substrate 8

2

16

Small-scale

0.817

High

1090375

ITSN2
Intersectin-2

1

18

Small-scale

0.740

High

987596

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.740

High

711332

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.724

High

1090337

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.724

High

1090384

MYO15
Unconventional myosin-XV

1

4

High-throughput

0.698

High

557264

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.692

High

168679

CSKP
Peripheral plasma membrane protein CASK

1

10

Small-scale

0.665

High

651302

CBL
E3 ubiquitin-protein ligase CBL

3

20

Small-scale

0.646

High

1090381

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

2

11

Small-scale

0.646

High

1090341

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

18

High-throughput

0.621

High

710206

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

710821

EPHB2
Ephrin type-B receptor 2

1

20

High-throughput

0.618

High

1034150

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.618

High

1090340

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.618

High

883089

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

2

0

Small-scale

0.605

High

425188

IPSP
Plasma serine protease inhibitor

2

3

High-throughput

0.576

High

1064980

FGL1
Fibrinogen-like protein 1

2

2

High-throughput

0.574

High

159341

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

18

Small-scale

0.573

High

462379

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

2

High-throughput

0.573

High

1090338

PI5PA
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

1

15

High-throughput

0.573

High

396008

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

1026709

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

10

High-throughput

0.555

High

177208

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

4

High-throughput

0.553

High

563696

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

1090350

MILR1
Allergin-1

1

16

High-throughput

0.536

High

1090374

GPC5B
G-protein coupled receptor family C group 5 member B

1

7

High-throughput

0.536

High

1090344

CF141
Uncharacterized protein C6orf141

2

1

High-throughput

0.526

High

1090380

RSP14
Radial spoke head 14 homolog

2

4

High-throughput

0.526

High

1090359

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

4

High-throughput

0.523

High

1090385

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

1

0

High-throughput

0.518

High

878312

MRP
MARCKS-related protein

1

0

High-throughput

0.513

High

424028

ITB3
Integrin beta-3

1

7

Small-scale

0.501

High

612071

ITB5
Integrin beta-5

1

7

Small-scale

0.501

High

159968

IDLC
Axonemal dynein light intermediate polypeptide 1

1

1

High-throughput

0.494

High

1090363

HOOK2
Protein Hook homolog 2

1

11

High-throughput

0.494

High

163427

MEIS2
Homeobox protein Meis2

1

1

High-throughput

0.489

High

872271

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.489

High

1090367

MND1
Meiotic nuclear division protein 1 homolog

1

1

High-throughput

0.489

High

1090376

ADA22
Disintegrin and metalloproteinase domain-containing protein 22

1

17

High-throughput

0.481

High

133741

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

2

High-throughput

0.479

High

164323

NRP1
Neuropilin-1

1

8

High-throughput

0.479

High

374555

RASH
GTPase HRas

1

14

High-throughput

0.479

High

375463

RASK
GTPase KRas

1

16

High-throughput

0.479

High

431797

ITB1
Integrin beta-1

1

6

Small-scale

0.479

High

460256

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

5

Small-scale

0.479

High

952787

ACTB
Actin, cytoplasmic 1

1

8

High-throughput

0.479

High

953415

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

977966

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

988323

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

995564

ACTC
Actin, alpha cardiac muscle 1

1

8

High-throughput

0.479

High

1031357

IFM3
Interferon-induced transmembrane protein 3

1

10

High-throughput

0.479

High

1090354

BICD2
Protein bicaudal D homolog 2

1

9

High-throughput

0.479

High

1090361

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.479

High

1090364

BICD1
Protein bicaudal D homolog 1

1

11

High-throughput

0.479

High

1068816

GOG8D
Putative golgin subfamily A member 8D

1

5

High-throughput

0.470

High

1090369

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.464

High

1090370

CH033
UPF0488 protein C8orf33

1

1

High-throughput

0.464

High

995009

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.460

High

1090343

TPRN
Taperin

1

0

High-throughput

0.460

High

1090347

S27A4
Long-chain fatty acid transport protein 4

1

0

High-throughput

0.460

High

1090332

STF1
Steroidogenic factor 1

1

10

High-throughput

0.457

High

1090345

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.445

High

1090355

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

2

High-throughput

0.445

High

558084

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.439

High

1090336

SF3B3
Splicing factor 3B subunit 3

1

1

High-throughput

0.439

High

1090362

NACC2
Nucleus accumbens-associated protein 2

1

11

High-throughput

0.439

High

1090377

GULP1
PTB domain-containing engulfment adapter protein 1

1

20

High-throughput

0.439

High

1090382

CTNA3
Catenin alpha-3

1

1

High-throughput

0.439

High

105838

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

227529

SPOP
Speckle-type POZ protein

1

5

High-throughput

0.437

High

247866

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

1090334

MDC1
Mediator of DNA damage checkpoint protein 1

1

10

High-throughput

0.437

High

1090348

FBX42
F-box only protein 42

1

2

High-throughput

0.437

High

1090349

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1090356

ESR2
Estrogen receptor beta

1

11

High-throughput

0.437

High

1090379

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

1030307

AMPD2
AMP deaminase 2

2

0

High-throughput

0.328

High

1090357

US6NL
USP6 N-terminal-like protein

1

0

Small-scale

0.324

High

1090366

XAGE2
X antigen family member 2

2

0

High-throughput

0.310

High

1090383

RCAN3
Calcipressin-3

2

0

High-throughput

0.300

High

1055213

MTG8
Protein CBFA2T1

1

0

High-throughput

0.299

High

1090333

BYST
Bystin

1

0

High-throughput

0.299

High

1090365

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.299

High

1090378

CS025
UPF0449 protein C19orf25

1

0

High-throughput

0.299

High

191960

TEX28
Testis-specific protein TEX28

1

0

High-throughput

0.282

High

339161

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

High-throughput

0.282

High

1090331

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.282

High

1090335

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.282

High

1090339

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.282

High

1090368

RM20
Large ribosomal subunit protein bL20m

1

0

High-throughput

0.282

High

217082

MS18B
Protein Mis18-beta

1

0

High-throughput

0.279

Low

568407

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

665968

IBP5
Insulin-like growth factor-binding protein 5

1

0

High-throughput

0.279

Low

1090346

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

1

0

High-throughput

0.279

Low

1090358

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.279

Low

1090360

FBXW5
F-box/WD repeat-containing protein 5

1

0

Small-scale

0.279

Low

1090371

LYRM4
LYR motif-containing protein 4

1

0

High-throughput

0.279

Low

1090373

TMM51
Transmembrane protein 51

1

0

High-throughput

0.279

Low

130875

RFXAP
Regulatory factor X-associated protein

1

0

High-throughput

0.251

Low

166650

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.251

Low

626433

CXCL2
C-X-C motif chemokine 2

1

0

High-throughput

0.251

Low

1081666

SCRN3
Secernin-3

1

0

High-throughput

0.251

Low

1090351

PRSR2
Proline and serine-rich protein 2

1

0

High-throughput

0.251

Low

1090352

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.251

Low

1090372

ARMC1
Armadillo repeat-containing protein 1

1

0

High-throughput

0.251

Low

258513

KIN17
DNA/RNA-binding protein KIN17

1

0

High-throughput

0.249

Low

1090342

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025