Protein: SH23A
SH2 domain-containing protein 3A (Novel SH2-containing protein 1)

Gene: SH23A, SH2D3A
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q9BRG2

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0007254 - JNK cascade
GO:0007264 - small GTPase-mediated signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363786

EGFR
Epidermal growth factor receptor

4

20

Small-scale

0.805

High

942846

BCAR1
Breast cancer anti-estrogen resistance protein 1

3

20

Small-scale

0.757

High

333277

RASL1
RasGAP-activating-like protein 1

1

20

High-throughput

0.618

High

411024

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.579

High

641666

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.579

High

966811

1433G
14-3-3 protein gamma

2

20

High-throughput

0.549

High

691379

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

451563

CENPB
Major centromere autoantigen B

2

1

High-throughput

0.526

High

1106501

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.489

High

161888

IMPA2
Inositol monophosphatase 2

1

2

High-throughput

0.489

High

186167

LX15B
Polyunsaturated fatty acid lipoxygenase ALOX15B

1

6

High-throughput

0.489

High

210779

KLK10
Kallikrein-10

1

3

High-throughput

0.489

High

257067

F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

1

5

High-throughput

0.489

High

261651

CATL2
Cathepsin L2

1

3

High-throughput

0.489

High

276623

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

9

High-throughput

0.489

High

296739

TUSC2
Tumor suppressor candidate 2

1

1

High-throughput

0.489

High

369500

AACT
Alpha-1-antichymotrypsin

1

8

High-throughput

0.489

High

423837

APOD
Apolipoprotein D

1

5

High-throughput

0.489

High

424257

S10A8
Protein S100-A8

1

12

High-throughput

0.489

High

445059

S10A9
Protein S100-A9

1

15

High-throughput

0.489

High

449578

HEXA
Beta-hexosaminidase subunit alpha

1

4

High-throughput

0.489

High

456267

CATD
Cathepsin D

1

1

High-throughput

0.489

High

457908

INVO
Involucrin

1

20

High-throughput

0.489

High

485817

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

3

High-throughput

0.489

High

537804

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.489

High

565695

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

2

High-throughput

0.489

High

568975

ANXA8
Annexin A8

1

11

High-throughput

0.489

High

582357

ARSA
Arylsulfatase A

1

4

High-throughput

0.489

High

604177

CXA1
Gap junction alpha-1 protein

1

11

High-throughput

0.489

High

635627

FILA
Filaggrin

1

12

High-throughput

0.489

High

635664

ASPG
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

1

1

High-throughput

0.489

High

652399

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

4

High-throughput

0.489

High

671847

ZA2G
Zinc-alpha-2-glycoprotein

1

6

High-throughput

0.489

High

682590

S100P
Protein S100-P

1

15

High-throughput

0.489

High

713440

SPB3
Serpin B3

1

9

High-throughput

0.489

High

724626

S10A7
Protein S100-A7

1

15

High-throughput

0.489

High

730198

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.489

High

874854

SPB4
Serpin B4

1

9

High-throughput

0.489

High

971937

1433E
14-3-3 protein epsilon

1

9

High-throughput

0.489

High

990669

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.489

High

1009710

NGAL
Neutrophil gelatinase-associated lipocalin

1

6

High-throughput

0.489

High

1013374

HTRA3
Serine protease HTRA3

1

1

High-throughput

0.489

High

1120493

SCRB2
Lysosome membrane protein 2

1

6

High-throughput

0.489

High

1154342

CYTM
Cystatin-M

1

1

High-throughput

0.489

High

1159412

ECM1
Extracellular matrix protein 1

1

1

High-throughput

0.489

High

1204025

FILA2
Filaggrin-2

1

14

High-throughput

0.489

High

1213816

KPRP
Keratinocyte proline-rich protein

1

3

High-throughput

0.489

High

1233109

P20D1
N-fatty-acyl-amino acid synthase/hydrolase PM20D1

1

2

High-throughput

0.489

High

1256982

FBX50
F-box only protein 50

1

2

High-throughput

0.489

High

1259458

TBA1A
Tubulin alpha-1A chain

1

20

High-throughput

0.489

High

1338065

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

1

High-throughput

0.489

High

1358562

POF1B
Protein POF1B

1

2

High-throughput

0.489

High

1396688

CPNS2
Calpain small subunit 2

1

3

High-throughput

0.489

High

1411128

RNAS7
Ribonuclease 7

1

1

High-throughput

0.489

High

1411132

CBPA4
Carboxypeptidase A4

1

1

High-throughput

0.489

High

730858

1433S
14-3-3 protein sigma

1

20

High-throughput

0.470

High

75715

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

3

High-throughput

0.437

High

1407448

TS101
Tumor susceptibility gene 101 protein

1

3

High-throughput

0.417

High

69541

A2ML1
Alpha-2-macroglobulin-like protein 1

1

3

High-throughput

0.407

High

1227355

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.407

High

130881

RFXAP
Regulatory factor X-associated protein

1

0

High-throughput

0.279

Low

289223

CREG1
Protein CREG1

1

0

High-throughput

0.279

Low

423696

ARGI1
Arginase-1

1

0

High-throughput

0.279

Low

467849

BGLR
Beta-glucuronidase

1

0

High-throughput

0.279

Low

582615

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.279

Low

609329

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.279

Low

627156

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.279

Low

692259

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.279

Low

1108808

ASAH1
Acid ceramidase

1

0

High-throughput

0.279

Low

1242362

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

1272462

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

1400647

GSDMA
Gasdermin-A

1

0

High-throughput

0.279

Low

1411129

RISC
Retinoid-inducible serine carboxypeptidase

1

0

High-throughput

0.279

Low

1411131

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.279

Low

1411130

NXF1
Nuclear RNA export factor 1

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025