Protein: LIPA
Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase)

Gene: LIPA, LIP5
Organism: Saccharomyces cerevisiae S288C
Interactions: 45
UniProt ID: P32875

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0009107 - lipoate biosynthetic process
GO:0016992 - lipoate synthase activity
GO:0046872 - metal ion binding
GO:0051539 - 4 iron, 4 sulfur cluster binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

746533

GBLP
Small ribosomal subunit protein RACK1

2

0

High-throughput

0.649

High

746252

NFU1
NifU-like protein, mitochondrial

2

1

Small-scale

0.584

High

746541

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.489

High

510333

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.479

High

746529

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.479

High

746537

GCSH
Glycine cleavage system H protein, mitochondrial

1

1

High-throughput

0.479

High

725911

PSK1
Serine/threonine-protein kinase PSK1

1

1

High-throughput

0.470

High

453128

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

Small-scale

0.458

High

514541

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

579097

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

746532

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.458

High

746536

BOL3
BolA-like protein 3

1

0

Small-scale

0.458

High

746539

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

746535

KSP1
Serine/threonine-protein kinase KSP1

1

1

High-throughput

0.457

High

746542

PRK1
Actin-regulating kinase PRK1

1

1

High-throughput

0.457

High

746540

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.445

High

746530

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

544281

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.407

High

746534

ANM1
Protein arginine N-methyltransferase 1

2

0

High-throughput

0.300

High

554466

TRK1
High-affinity potassium transport protein

1

0

High-throughput

0.269

Low

713217

SEC65
Signal recognition particle subunit SEC65

1

0

High-throughput

0.269

Low

746538

RV167
Reduced viability upon starvation protein 167

1

0

High-throughput

0.269

Low

746545

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

0

High-throughput

0.261

Low

149666

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

383599

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

410021

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

434956

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

435863

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

441803

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

454958

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

502940

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504121

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

512339

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

512905

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

674510

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

689349

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

706611

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

746528

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

746531

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

746543

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

746544

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.249

Low

746546

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

746547

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

712961

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.238

Low

523455

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025