Protein: PRK1
Actin-regulating kinase PRK1 (EC 2.7.11.1) (p53-regulating kinase 1)

Gene: PRK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 117
UniProt ID: P40494

Gene Ontology (top 5):
GO:0000147 - actin cortical patch assembly
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

587313

ABP1
Actin-binding protein

6

4

Small-scale

0.746

High

736109

ARP2
Actin-related protein 2

1

3

Small-scale

0.740

High

739074

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

6

7

Small-scale

0.734

High

449134

CALM
Calmodulin

1

12

High-throughput

0.691

High

793160

AKL1
Serine/threonine-protein kinase AKL1

1

17

High-throughput

0.691

High

825423

CDC14
Tyrosine-protein phosphatase CDC14

1

6

High-throughput

0.691

High

744866

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

3

11

Small-scale

0.683

High

656974

BUR1
Serine/threonine-protein kinase BUR1

1

11

High-throughput

0.665

High

403536

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.656

High

694147

CDC15
Cell division control protein 15

1

18

High-throughput

0.647

High

757701

EDE1
EH domain-containing and endocytosis protein 1

1

13

Small-scale

0.647

High

815816

BEM2
GTPase-activating protein BEM2/IPL2

1

6

Small-scale

0.647

High

817259

ARB1
ABC transporter ATP-binding protein ARB1

1

2

High-throughput

0.647

High

825420

ACT
Actin

1

1

High-throughput

0.646

High

751857

SLA2
Protein SLA2

2

15

Small-scale

0.619

High

825439

YRA1
RNA annealing protein YRA1

1

5

High-throughput

0.618

High

579527

HSC82
ATP-dependent molecular chaperone HSC82

1

13

High-throughput

0.618

High

797203

OPY1
Pleckstrin homology domain protein OPY1

1

0

High-throughput

0.614

High

760275

BMH2
Protein BMH2

2

20

High-throughput

0.611

High

806083

AP18A
Clathrin coat assembly protein AP180A

3

13

Small-scale

0.609

High

825442

LAS17
Proline-rich protein LAS17

2

4

Small-scale

0.595

High

825400

PRK1
Actin-regulating kinase PRK1

1

18

High-throughput

0.590

High

815633

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

5

High-throughput

0.587

High

754212

MSN4
Zinc finger protein MSN4

1

1

High-throughput

0.579

High

825416

AP18B
Clathrin coat assembly protein AP180B

2

13

High-throughput

0.570

High

825411

BUD4
Bud site selection protein 4

1

0

High-throughput

0.541

High

798145

ARPC1
Actin-related protein 2/3 complex subunit 1

1

8

High-throughput

0.541

High

637228

PWP1
Periodic tryptophan protein 1

1

3

High-throughput

0.536

High

745011

YSC84
Protein YSC84

1

7

High-throughput

0.536

High

790578

VRP1
Verprolin

1

2

High-throughput

0.536

High

801058

FKS1
1,3-beta-glucan synthase component FKS1

1

1

High-throughput

0.536

High

809191

END3
Actin cytoskeleton-regulatory complex protein END3

1

11

High-throughput

0.536

High

816243

HSP7E
Heat shock protein SSC3, mitochondrial

1

11

High-throughput

0.536

High

825425

DYL1
Dynein light chain 1, cytoplasmic

1

2

High-throughput

0.536

High

825444

ENT1
Epsin-1

1

5

High-throughput

0.536

High

825433

TSR1
Ribosome biogenesis protein TSR1

1

2

High-throughput

0.515

High

670801

SIS1
Protein SIS1

1

2

High-throughput

0.514

High

825430

ENT2
Epsin-2

1

5

High-throughput

0.508

High

460346

SYV
Valine--tRNA ligase, mitochondrial

1

1

Small-scale

0.501

High

514946

YA11A
Transposon Ty1-A Gag polyprotein

1

2

High-throughput

0.501

High

515002

YE11A
Transposon Ty1-ER1 Gag polyprotein

1

1

High-throughput

0.501

High

600692

SEC2
Rab guanine nucleotide exchange factor SEC2

1

3

High-throughput

0.501

High

678107

SYP1
Suppressor of yeast profilin deletion

1

1

Small-scale

0.501

High

684748

RL5
Large ribosomal subunit protein uL18

1

2

Small-scale

0.501

High

760554

SCD5
Protein SCD5

1

1

Small-scale

0.501

High

797151

AIM3
Altered inheritance of mitochondria protein 3

1

4

High-throughput

0.501

High

805163

SFB3
SED5-binding protein 3

1

5

Small-scale

0.501

High

825403

BNI1
Protein BNI1

1

3

Small-scale

0.501

High

825405

LSB3
LAS seventeen-binding protein 3

1

11

High-throughput

0.501

High

825407

SAC3
Nuclear mRNA export protein SAC3

1

1

Small-scale

0.501

High

825412

MET5
Sulfite reductase [NADPH] subunit beta

1

2

Small-scale

0.501

High

825441

YD21A
Transposon Ty2-DR1 Gag polyprotein

1

2

High-throughput

0.501

High

825443

YN12A
Transposon Ty1-NL2 Gag polyprotein

1

2

High-throughput

0.501

High

626765

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.500

High

644791

CLH
Clathrin heavy chain

1

6

High-throughput

0.500

High

825435

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.500

High

825436

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

1

High-throughput

0.500

High

438818

CYSD
Homocysteine/cysteine synthase

1

0

High-throughput

0.480

High

446234

PHSG
Glycogen phosphorylase

1

0

Small-scale

0.480

High

745430

GYP6
GTPase-activating protein GYP6

1

0

High-throughput

0.480

High

795977

NCL1
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase

1

0

Small-scale

0.480

High

797214

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.480

High

800938

AGM1
Phosphoacetylglucosamine mutase

1

0

High-throughput

0.480

High

803134

ECM29
Proteasome component ECM29

1

0

Small-scale

0.480

High

818110

SHO1
High osmolarity signaling protein SHO1

1

0

High-throughput

0.480

High

825402

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.480

High

825406

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.480

High

825426

ADD37
Alpha1-proteinase inhibitor-degradation deficient protein 37

1

0

High-throughput

0.480

High

825427

RMD1
Sporulation protein RMD1

1

0

Small-scale

0.480

High

825429

UFO1
Ubiquitin ligase complex F-box protein UFO1

1

0

Small-scale

0.480

High

825432

SYM1
Protein SYM1

1

0

High-throughput

0.480

High

825434

HBT1
Protein HBT1

1

0

High-throughput

0.480

High

825437

KAD6
Adenylate kinase isoenzyme 6 homolog FAP7

1

0

High-throughput

0.480

High

679768

CDC48
Cell division control protein 48

1

4

High-throughput

0.479

High

709807

BMH1
Protein BMH1

1

20

High-throughput

0.479

High

825413

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.479

High

732156

COPG
Coatomer subunit gamma

1

20

Small-scale

0.457

High

746542

LIPA
Lipoyl synthase, mitochondrial

1

1

High-throughput

0.457

High

801685

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

4

High-throughput

0.457

High

803361

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

3

High-throughput

0.457

High

823089

VPS27
Vacuolar protein sorting-associated protein 27

1

2

High-throughput

0.457

High

825410

DPB11
DNA replication regulator DPB11

1

1

Small-scale

0.457

High

825418

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

8

High-throughput

0.457

High

825419

YL460
Uncharacterized protein YLR460C

1

1

High-throughput

0.457

High

825424

RNT1
Ribonuclease 3

1

1

High-throughput

0.457

High

825445

RS25A
Small ribosomal subunit protein eS25A

1

1

High-throughput

0.457

High

425131

OTC
Ornithine carbamoyltransferase

1

2

High-throughput

0.457

High

619363

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.457

High

510552

HSP77
Import motor subunit, mitochondrial

1

11

High-throughput

0.445

High

524174

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

526877

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

545144

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.445

High

741723

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.445

High

824452

6P21
6-phosphofructo-2-kinase 1

1

3

High-throughput

0.445

High

707302

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

825401

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

825422

NUM1
Nuclear migration protein NUM1

1

15

High-throughput

0.437

High

816712

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.426

High

825421

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.296

High

814140

SAW1
Single-strand annealing weakened protein 1

1

0

High-throughput

0.269

Low

825404

BRE2
COMPASS component BRE2

1

0

High-throughput

0.269

Low

554471

TRK1
High-affinity potassium transport protein

1

0

Small-scale

0.261

Low

645062

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.261

Low

745191

CDC13
Cell division control protein 13

1

0

High-throughput

0.261

Low

745479

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.261

Low

803987

RSC30
Chromatin structure-remodeling complex protein RSC30

1

0

High-throughput

0.261

Low

814118

HPH2
Protein HPH2

1

0

High-throughput

0.261

Low

825408

STB2
Protein STB2

1

0

High-throughput

0.261

Low

825409

GON7
EKC/KEOPS complex subunit GON7

1

0

Small-scale

0.261

Low

825414

NU188
Nucleoporin NUP188

1

0

Small-scale

0.261

Low

825415

MST27
Multicopy suppressor of SEC21 protein 27

1

0

High-throughput

0.261

Low

825417

REXO1
RNA exonuclease 1

1

0

High-throughput

0.261

Low

825428

YMD7
Uncharacterized protein YML037C

1

0

High-throughput

0.261

Low

825431

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.261

Low

825438

SAS10
Something about silencing protein 10

1

0

High-throughput

0.261

Low

825440

CRM2
Homeostatic regulator of DAG

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025