Protein: LONM
Lon protease homolog, mitochondrial (EC 3.4.21.53)

Gene: LONM, PIM1
Organism: Saccharomyces cerevisiae S288C
Interactions: 211
UniProt ID: P36775

Gene Ontology (top 5):
GO:0003697 - single-stranded DNA binding
GO:0004176 - ATP-dependent peptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

785906

LONM
Lon protease homolog, mitochondrial

3

18

Small-scale

0.834

High

752146

HSP78
Heat shock protein 78, mitochondrial

2

8

High-throughput

0.754

High

394462

EF1A
Elongation factor 1-alpha

2

5

High-throughput

0.737

High

726945

HS104
Heat shock protein 104

2

10

High-throughput

0.737

High

579220

HSC82
ATP-dependent molecular chaperone HSC82

3

12

High-throughput

0.640

High

604939

MDHM
Malate dehydrogenase, mitochondrial

3

12

Small-scale

0.640

High

679582

CDC48
Cell division control protein 48

1

14

High-throughput

0.618

High

785930

PRS4
26S proteasome regulatory subunit 4 homolog

1

19

High-throughput

0.618

High

785992

BMS1
Ribosome biogenesis protein BMS1

1

1

High-throughput

0.618

High

785940

MRX6
MIOREX complex component 6

3

0

Small-scale

0.613

High

786008

PET20
Protein PET20, mitochondrial

3

0

Small-scale

0.613

High

531303

METK1
S-adenosylmethionine synthase 1

2

3

High-throughput

0.588

High

701513

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

2

10

High-throughput

0.588

High

392577

HSP82
ATP-dependent molecular chaperone HSP82

2

12

High-throughput

0.584

High

785911

NCB5R
NADH-cytochrome b5 reductase 1

2

9

High-throughput

0.584

High

785932

MAM33
Mitochondrial acidic protein MAM33

2

4

High-throughput

0.584

High

523659

HSP71
Heat shock protein SSA1

2

10

High-throughput

0.571

High

785943

TOM22
Mitochondrial import receptor subunit TOM22

2

0

High-throughput

0.559

High

430832

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

7

Small-scale

0.553

High

526444

HSP72
Heat shock protein SSA2

2

10

High-throughput

0.552

High

574668

KSS1
Mitogen-activated protein kinase KSS1

1

8

High-throughput

0.536

High

435019

RS3
Small ribosomal subunit protein uS3

2

4

High-throughput

0.533

High

585546

BGL2
Glucan 1,3-beta-glucosidase

2

1

High-throughput

0.533

High

785990

RS10A
Small ribosomal subunit protein eS10A

2

6

High-throughput

0.533

High

481999

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.513

High

427228

RLA0
Large ribosomal subunit protein uL10

1

5

High-throughput

0.489

High

678316

RSC6
Chromatin structure-remodeling complex protein RSC6

1

1

High-throughput

0.489

High

785957

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

7

High-throughput

0.489

High

785966

USA1
U1 SNP1-associating protein 1

1

1

High-throughput

0.489

High

357705

CYC1
Cytochrome c isoform 1

1

2

High-throughput

0.479

High

359203

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

5

High-throughput

0.479

High

359463

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

5

High-throughput

0.479

High

367003

ATPB
ATP synthase subunit beta, mitochondrial

1

12

High-throughput

0.479

High

370470

ATIF
F(1)-ATPase inhibitor IF(1), mitochondrial

1

2

High-throughput

0.479

High

376223

RAS2
Ras-like protein 2

1

7

High-throughput

0.479

High

376292

YPT1
GTP-binding protein YPT1

1

4

High-throughput

0.479

High

416111

SYTC
Threonine--tRNA ligase, cytoplasmic

1

8

High-throughput

0.479

High

432000

ATPF
ATP synthase subunit 4, mitochondrial

1

3

High-throughput

0.479

High

439575

LEU1
2-isopropylmalate synthase

1

3

High-throughput

0.479

High

450713

KAD2
Adenylate kinase

1

1

High-throughput

0.479

High

452883

ATPA
ATP synthase subunit alpha, mitochondrial

1

12

High-throughput

0.479

High

460329

SYV
Valine--tRNA ligase, mitochondrial

1

7

High-throughput

0.479

High

482192

ATPO
ATP synthase subunit 5, mitochondrial

1

4

High-throughput

0.479

High

488657

HEM1
5-aminolevulinate synthase, mitochondrial

1

2

High-throughput

0.479

High

510408

HSP77
Import motor subunit, mitochondrial

1

8

High-throughput

0.479

High

514589

RS18A
Small ribosomal subunit protein uS13A

1

3

High-throughput

0.479

High

554601

RM02
Large ribosomal subunit protein bL27m

1

1

High-throughput

0.479

High

594932

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

4

High-throughput

0.479

High

598847

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

5

High-throughput

0.479

High

622353

ACON
Aconitate hydratase, mitochondrial

1

5

High-throughput

0.479

High

626694

HSP60
Heat shock protein 60, mitochondrial

1

7

High-throughput

0.479

High

632660

DBP4
ATP-dependent RNA helicase HCA4

1

11

High-throughput

0.479

High

641093

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

1

High-throughput

0.479

High

647084

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

4

High-throughput

0.479

High

656747

KC12
Casein kinase I homolog 2

1

4

High-throughput

0.479

High

668900

ERG6
Sterol 24-C-methyltransferase ERG6

1

3

High-throughput

0.479

High

673494

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

4

High-throughput

0.479

High

675918

MAS5
Mitochondrial protein import protein MAS5

1

9

High-throughput

0.479

High

692555

NSR1
Nuclear localization sequence-binding protein

1

8

High-throughput

0.479

High

701690

URA7
CTP synthase 1

1

4

High-throughput

0.479

High

705759

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

10

High-throughput

0.479

High

723173

ATP7
ATP synthase subunit d, mitochondrial

1

2

Small-scale

0.479

High

733652

GLNA
Glutamine synthetase

1

6

High-throughput

0.479

High

734770

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

9

High-throughput

0.479

High

741390

HSP7F
Heat shock protein homolog SSE1

1

16

High-throughput

0.479

High

781356

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

785908

ATPG
ATP synthase subunit gamma, mitochondrial

1

3

High-throughput

0.479

High

785909

MAK5
ATP-dependent RNA helicase MAK5

1

10

High-throughput

0.479

High

785912

KPR3
Ribose-phosphate pyrophosphokinase 3

1

3

High-throughput

0.479

High

785913

YHJ3
Uncharacterized protein YHR033W

1

1

High-throughput

0.479

High

785915

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

8

High-throughput

0.479

High

785916

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

5

High-throughput

0.479

High

785924

HXT6
High-affinity hexose transporter HXT6

1

5

High-throughput

0.479

High

785925

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

1

High-throughput

0.479

High

785926

FHP
Flavohemoprotein

1

7

High-throughput

0.479

High

785927

COX15
Heme A synthase COX15

1

1

High-throughput

0.479

High

785929

NDH1
External NADH-ubiquinone oxidoreductase 1, mitochondrial

1

7

High-throughput

0.479

High

785934

PHB1
Prohibitin-1

1

8

Small-scale

0.479

High

785936

LSB3
LAS seventeen-binding protein 3

1

7

High-throughput

0.479

High

785937

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

8

High-throughput

0.479

High

785941

VATG
V-type proton ATPase subunit G

1

2

High-throughput

0.479

High

785944

PHB2
Prohibitin-2

1

8

Small-scale

0.479

High

785949

PBP1
PAB1-binding protein 1

1

1

High-throughput

0.479

High

785951

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

6

High-throughput

0.479

High

785954

ATPJ
ATP synthase subunit e, mitochondrial

1

1

High-throughput

0.479

High

785956

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

2

High-throughput

0.479

High

785958

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

3

High-throughput

0.479

High

785964

ESP1
Separin

1

1

High-throughput

0.479

High

785965

RT10
Small ribosomal subunit protein uS10m

1

4

High-throughput

0.479

High

785968

RUVB1
RuvB-like protein 1

1

6

High-throughput

0.479

High

785970

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

785971

DHR1
Probable ATP-dependent RNA helicase DHR1

1

3

High-throughput

0.479

High

785973

HFD1
Fatty aldehyde dehydrogenase HFD1

1

10

High-throughput

0.479

High

785976

RTN1
Reticulon-like protein 1

1

3

High-throughput

0.479

High

785977

DBP9
ATP-dependent RNA helicase DBP9

1

9

High-throughput

0.479

High

785981

MHR1
Large ribosomal subunit protein mL67

1

1

High-throughput

0.479

High

785982

RM35
Large ribosomal subunit protein mL38

1

2

High-throughput

0.479

High

785983

PUF3
mRNA-binding protein PUF3

1

2

High-throughput

0.479

High

785989

HRK1
Serine/threonine-protein kinase HRK1

1

7

High-throughput

0.479

High

785993

NEW1
[NU+] prion formation protein 1

1

8

High-throughput

0.479

High

785995

SGT2
Small glutamine-rich tetratricopeptide repeat-containing protein 2

1

11

High-throughput

0.479

High

785996

ATPD
ATP synthase subunit delta, mitochondrial

1

1

High-throughput

0.479

High

785998

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

786001

RDL1
Thiosulfate:glutathione sulfurtransferase

1

3

High-throughput

0.479

High

786002

TCB1
Tricalbin-1

1

8

High-throughput

0.479

High

786007

ODC2
Mitochondrial 2-oxodicarboxylate carrier 2

1

6

High-throughput

0.479

High

360786

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.458

High

382885

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

561679

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.458

High

746532

LIPA
Lipoyl synthase, mitochondrial

1

0

High-throughput

0.458

High

783973

RM10
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.458

High

784040

RM11
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.458

High

785907

CBP4
Assembly factor CBP4

1

0

High-throughput

0.458

High

785931

RT25
Small ribosomal subunit protein mS23

1

0

High-throughput

0.458

High

785939

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

785960

RM13
Large ribosomal subunit protein mL50

1

0

High-throughput

0.458

High

785962

RPM2
Ribonuclease P protein component, mitochondrial

1

0

High-throughput

0.458

High

785967

RT08
Small ribosomal subunit protein uS8m

1

0

High-throughput

0.458

High

785975

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

785979

ATPK
ATP synthase subunit f, mitochondrial

1

0

High-throughput

0.458

High

785999

NCE2
Non-classical export protein 2

1

0

High-throughput

0.458

High

786000

CIM1
Mitochondrial HMG-box protein CIM1

1

0

Small-scale

0.458

High

786006

NOP14
Nucleolar complex protein 14

1

0

High-throughput

0.458

High

453546

PYR1
Multifunctional protein URA2

1

11

High-throughput

0.445

High

544530

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

592181

VATB
V-type proton ATPase subunit B

1

12

High-throughput

0.445

High

785920

SSZ1
Ribosome-associated complex subunit SSZ1

1

8

High-throughput

0.445

High

149708

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.437

High

381073

H2B1
Histone H2B.1

1

9

High-throughput

0.437

High

381493

H2B2
Histone H2B.2

1

9

High-throughput

0.437

High

382040

H4
Histone H4

1

2

High-throughput

0.437

High

383113

RLA4
Large ribosomal subunit protein P2B

1

3

High-throughput

0.437

High

383647

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.437

High

403470

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

5

High-throughput

0.437

High

433585

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.437

High

454099

DHE4
NADP-specific glutamate dehydrogenase 1

1

5

High-throughput

0.437

High

454209

LEUC
3-isopropylmalate dehydratase

1

5

High-throughput

0.437

High

455008

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.437

High

502988

RS22A
Small ribosomal subunit protein uS8A

1

6

High-throughput

0.437

High

531693

RL4A
Large ribosomal subunit protein uL4A

1

4

High-throughput

0.437

High

536008

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

1

7

High-throughput

0.437

High

555306

EI2BD
Translation initiation factor eIF2B subunit delta

1

4

High-throughput

0.437

High

560578

GAL2
Galactose transporter

1

5

High-throughput

0.437

High

575434

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

6

High-throughput

0.437

High

578228

TAL1
Transaldolase

1

3

High-throughput

0.437

High

645386

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.437

High

674563

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.437

High

689396

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.437

High

706834

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

736787

AROG
Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited

1

1

High-throughput

0.437

High

738366

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

3

High-throughput

0.437

High

740144

RPN2
26S proteasome regulatory subunit RPN2

1

18

High-throughput

0.437

High

740715

SRP40
Suppressor protein SRP40

1

1

High-throughput

0.437

High

745705

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

8

High-throughput

0.437

High

747308

RSSA1
Small ribosomal subunit protein uS2A

1

4

High-throughput

0.437

High

747803

SMY2
Protein SMY2

1

2

High-throughput

0.437

High

748348

SC61A
Protein transport protein SEC61

1

5

High-throughput

0.437

High

750064

MRT4
Ribosome assembly factor MRT4

1

5

High-throughput

0.437

High

751380

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.437

High

778271

RS27A
Small ribosomal subunit protein eS27A

1

5

High-throughput

0.437

High

785910

IF5
Eukaryotic translation initiation factor 5

1

5

High-throughput

0.437

High

785914

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

785921

YHP7
Uncharacterized protein YHR097C

1

2

High-throughput

0.437

High

785922

NACA
Nascent polypeptide-associated complex subunit alpha

1

2

High-throughput

0.437

High

785923

SEC31
Protein transport protein SEC31

1

13

High-throughput

0.437

High

785933

GVP36
Protein GVP36

1

2

High-throughput

0.437

High

785938

NET1
Nucleolar protein NET1

1

1

High-throughput

0.437

High

785942

RL38
Large ribosomal subunit protein eL38

1

3

High-throughput

0.437

High

785945

YPT32
GTP-binding protein YPT32/YPT11

1

5

High-throughput

0.437

High

785946

ARO8
Aromatic/aminoadipate aminotransferase 1

1

2

High-throughput

0.437

High

785947

YGO0
Uncharacterized membrane protein YGL140C

1

1

High-throughput

0.437

High

785948

YG3A
Uncharacterized protein YGR130C

1

18

High-throughput

0.437

High

785950

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.437

High

785953

H3
Histone H3

1

6

High-throughput

0.437

High

785955

RL34A
Large ribosomal subunit protein eL34A

1

1

High-throughput

0.437

High

785959

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.437

High

785961

SMD1
Small nuclear ribonucleoprotein Sm D1

1

1

High-throughput

0.437

High

785969

HMO1
High mobility group protein 1

1

5

High-throughput

0.437

High

785972

UTP15
U3 small nucleolar RNA-associated protein 15

1

7

High-throughput

0.437

High

785978

ESF1
Pre-rRNA-processing protein ESF1

1

1

High-throughput

0.437

High

785984

NOC3
Nucleolar complex-associated protein 3

1

1

High-throughput

0.437

High

785985

RLP24
Ribosome biogenesis protein RLP24

1

3

High-throughput

0.437

High

785986

GAS5
1,3-beta-glucanosyltransferase GAS5

1

1

High-throughput

0.437

High

785987

NOP12
Nucleolar protein 12

1

6

High-throughput

0.437

High

785991

RRS1
Regulator of ribosome biosynthesis

1

1

High-throughput

0.437

High

785997

MAK21
Ribosome biogenesis protein MAK21

1

2

High-throughput

0.437

High

786003

CMR1
DNA damage-binding protein CMR1

1

11

High-throughput

0.437

High

786004

H2AZ
Histone H2A.Z

1

3

High-throughput

0.437

High

386672

TBB
Tubulin beta chain

1

8

High-throughput

0.407

High

785917

RPN1
26S proteasome regulatory subunit RPN1

1

18

High-throughput

0.407

High

785935

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.407

High

785980

SUE1
Protein SUE1, mitochondrial

2

0

Small-scale

0.305

High

745578

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.279

Low

64241

YP010
UPF0495 protein YPR010C-A

1

0

Small-scale

0.249

Low

427559

RLA1
Large ribosomal subunit protein P1A

1

0

High-throughput

0.249

Low

428000

CHO2
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.249

Low

632253

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low

673416

AGP1
General amino acid permease AGP1

1

0

High-throughput

0.249

Low

701628

PYRD
Dihydroorotate dehydrogenase

1

0

High-throughput

0.249

Low

752056

ECT1
Ethanolamine-phosphate cytidylyltransferase

1

0

High-throughput

0.249

Low

782000

PET10
Protein PET10

1

0

High-throughput

0.249

Low

785918

CIC1
Proteasome-interacting protein CIC1

1

0

High-throughput

0.249

Low

785919

GIC1
GTPase-interacting component 1

1

0

High-throughput

0.249

Low

785928

IES2
Ino eighty subunit 2

1

0

High-throughput

0.249

Low

785952

DOS2
Protein DOS2

1

0

High-throughput

0.249

Low

785963

MUK1
Protein MUK1

1

0

High-throughput

0.249

Low

785974

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

785988

NOP8
60S ribosome subunit biogenesis protein NOP8

1

0

High-throughput

0.249

Low

785994

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.249

Low

786005

NOP10
H/ACA ribonucleoprotein complex subunit NOP10

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025