Protein: TOP1M
DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.6.2.1)

Gene: TOP1M, TOP1MT
Organism: Homo sapiens
Interactions: 33
UniProt ID: Q969P6

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003917 - DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0005654 - nucleoplasm
GO:0005694 - chromosome
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

542150

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.691

High

667971

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.536

High

1065345

SSRP1
FACT complex subunit SSRP1

1

8

High-throughput

0.536

High

1163123

H2B2E
Histone H2B type 2-E

1

3

High-throughput

0.536

High

1357903

LEO1
RNA polymerase-associated protein LEO1

1

1

High-throughput

0.536

High

414357

P53
Cellular tumor antigen p53

1

1

High-throughput

0.527

High

626319

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.513

High

508387

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

848159

MAGA1
Melanoma-associated antigen 1

1

2

High-throughput

0.489

High

954567

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.489

High

1367774

TFG
Protein TFG

1

1

High-throughput

0.489

High

1380705

CEP89
Centrosomal protein of 89 kDa

1

3

High-throughput

0.489

High

223238

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

331212

KI20A
Kinesin-like protein KIF20A

1

6

High-throughput

0.479

High

756001

MCM5
DNA replication licensing factor MCM5

1

6

High-throughput

0.479

High

879336

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

1035826

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.479

High

1132880

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.479

High

1137124

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

7

High-throughput

0.479

High

1137918

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1360984

P66B
Transcriptional repressor p66-beta

1

1

High-throughput

0.479

High

1380707

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

1380708

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

1

High-throughput

0.479

High

1380709

ANLN
Anillin

1

1

High-throughput

0.479

High

1380710

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1281581

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

157707

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

1140657

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

1380704

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.437

High

1380706

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.279

Low

869070

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.249

Low

1016144

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

1258658

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025