Protein: NUP58
Nucleoporin p58/p45 (58 kDa nucleoporin) (Nucleoporin-like protein 1)

Gene: NUP58
Organism: Homo sapiens
Interactions: 178
UniProt ID: Q9BVL2

Gene Ontology (top 5):
GO:0005635 - nuclear envelope
GO:0005643 - nuclear pore
GO:0006913 - nucleocytoplasmic transport
GO:0008139 - nuclear localization sequence binding
GO:0015031 - protein transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1276153

NUP54
Nucleoporin p54

11

19

High-throughput

0.980

High

789212

NUP62
Nuclear pore glycoprotein p62

10

19

High-throughput

0.977

High

1415465

N62CL
Nucleoporin-62 C-terminal-like protein

2

11

High-throughput

0.811

High

1093943

TRAF1
TNF receptor-associated factor 1

5

2

High-throughput

0.660

High

1339161

NUP35
Nucleoporin NUP35

3

1

High-throughput

0.656

High

1415476

ABI3
ABI gene family member 3

4

1

High-throughput

0.642

High

938181

PKNX1
Homeobox protein PKNOX1

4

3

High-throughput

0.637

High

775595

NU214
Nuclear pore complex protein Nup214

2

15

Small-scale

0.611

High

1399442

WDFY2
WD repeat and FYVE domain-containing protein 2

3

4

High-throughput

0.609

High

1415484

COG6
Conserved oligomeric Golgi complex subunit 6

2

1

High-throughput

0.606

High

1415464

OSBL6
Oxysterol-binding protein-related protein 6

2

0

High-throughput

0.602

High

1415469

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

2

0

High-throughput

0.602

High

291519

NU155
Nuclear pore complex protein Nup155

2

10

High-throughput

0.584

High

272747

BRE1B
E3 ubiquitin-protein ligase BRE1B

2

1

High-throughput

0.574

High

1141901

EEA1
Early endosome antigen 1

2

1

High-throughput

0.574

High

1402818

TM209
Transmembrane protein 209

2

0

High-throughput

0.559

High

1382336

RN166
E3 ubiquitin-protein ligase RNF166

2

2

High-throughput

0.558

High

163470

MEIS2
Homeobox protein Meis2

2

3

High-throughput

0.553

High

1277564

K1C28
Keratin, type I cytoskeletal 28

2

1

High-throughput

0.553

High

1277623

K1C27
Keratin, type I cytoskeletal 27

2

1

High-throughput

0.553

High

1396168

PKNX2
Homeobox protein PKNOX2

2

3

High-throughput

0.553

High

1415479

UBQL2
Ubiquilin-2

2

2

High-throughput

0.553

High

890580

RBP2
E3 SUMO-protein ligase RanBP2

1

3

High-throughput

0.536

High

916033

NUP98
Nuclear pore complex protein Nup98-Nup96

1

20

High-throughput

0.536

High

945307

NU107
Nuclear pore complex protein Nup107

1

8

High-throughput

0.536

High

981674

RAN
GTP-binding nuclear protein Ran

1

2

High-throughput

0.536

High

1134703

NUMA1
Nuclear mitotic apparatus protein 1

1

2

High-throughput

0.536

High

1210367

NU188
Nucleoporin NUP188

1

1

High-throughput

0.536

High

1323450

NUP93
Nuclear pore complex protein Nup93

1

8

High-throughput

0.536

High

1365895

NU205
Nuclear pore complex protein Nup205

1

9

High-throughput

0.536

High

1415483

UBQL1
Ubiquilin-1

1

2

High-throughput

0.523

High

1357281

CHMP7
Charged multivesicular body protein 7

1

1

High-throughput

0.515

High

192635

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.513

High

1131891

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.513

High

1413755

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.513

High

691840

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.508

High

668708

APC
Adenomatous polyposis coli protein

1

1

High-throughput

0.494

High

1415463

TRI54
Tripartite motif-containing protein 54

1

2

High-throughput

0.494

High

1357204

BRK1
Protein BRICK1

1

0

High-throughput

0.493

High

1398546

COG8
Conserved oligomeric Golgi complex subunit 8

1

0

High-throughput

0.493

High

1405608

TSNAX
Translin-associated protein X

1

0

High-throughput

0.493

High

1152236

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.489

High

1382374

SPSB4
SPRY domain-containing SOCS box protein 4

1

3

High-throughput

0.489

High

1408506

GDF15
Growth/differentiation factor 15

1

2

High-throughput

0.489

High

1415472

GDF3
Growth/differentiation factor 3

1

1

High-throughput

0.489

High

173300

XPO1
Exportin-1

1

20

Small-scale

0.479

High

849400

RANG
Ran-specific GTPase-activating protein

1

10

High-throughput

0.479

High

1199368

GLE1
mRNA export factor GLE1

1

5

High-throughput

0.479

High

1252211

SYNE3
Nesprin-3

1

2

High-throughput

0.479

High

1289292

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

1

High-throughput

0.479

High

1415477

NXF1
Nuclear RNA export factor 1

1

6

High-throughput

0.479

High

1415480

XPO7
Exportin-7

1

7

High-throughput

0.479

High

1325047

EH1L1
EH domain-binding protein 1-like protein 1

1

6

High-throughput

0.470

High

296560

STAM2
Signal transducing adapter molecule 2

1

2

High-throughput

0.470

High

837084

ELK3
ETS domain-containing protein Elk-3

1

1

High-throughput

0.470

High

944732

KLF3
Krueppel-like factor 3

1

1

High-throughput

0.470

High

946029

VSX2
Visual system homeobox 2

1

1

High-throughput

0.470

High

1118769

KLF5
Krueppel-like factor 5

1

1

High-throughput

0.470

High

1120605

DPYS
Dihydropyrimidinase

1

1

High-throughput

0.470

High

1121944

DELE1
DAP3-binding cell death enhancer 1

1

1

High-throughput

0.470

High

1198143

RHG29
Rho GTPase-activating protein 29

1

1

High-throughput

0.470

High

1231706

LEG9C
Galectin-9C

1

1

High-throughput

0.470

High

1232985

OTU7B
OTU domain-containing protein 7B

1

2

High-throughput

0.470

High

1239379

ESRP1
Epithelial splicing regulatory protein 1

1

2

High-throughput

0.470

High

1242695

KLC3
Kinesin light chain 3

1

1

High-throughput

0.470

High

1244715

TTC33
Tetratricopeptide repeat protein 33

1

1

High-throughput

0.470

High

1307868

TMTC1
Protein O-mannosyl-transferase TMTC1

1

2

High-throughput

0.470

High

1326218

PNKD
Probable thioesterase PNKD

1

1

High-throughput

0.470

High

1326406

STX19
Syntaxin-19

1

1

High-throughput

0.470

High

1348750

BAHD1
Bromo adjacent homology domain-containing 1 protein

1

1

High-throughput

0.470

High

1368294

STAM1
Signal transducing adapter molecule 1

1

2

High-throughput

0.470

High

1389364

RNF31
E3 ubiquitin-protein ligase RNF31

1

4

High-throughput

0.470

High

1392045

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

1

High-throughput

0.470

High

1398275

ZN488
Zinc finger protein 488

1

1

High-throughput

0.470

High

1408525

AKAP9
A-kinase anchor protein 9

1

1

High-throughput

0.470

High

1410934

FYCO1
FYVE and coiled-coil domain-containing protein 1

1

2

High-throughput

0.470

High

1415462

SCAPE
S phase cyclin A-associated protein in the endoplasmic reticulum

1

2

High-throughput

0.470

High

1415466

UBQL3
Ubiquilin-3

1

2

High-throughput

0.470

High

248070

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

272437

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.437

High

589583

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

696395

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

769064

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

851807

NKX21
Homeobox protein Nkx-2.1

1

2

High-throughput

0.437

High

935082

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.437

High

1161641

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.437

High

1214566

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

1

High-throughput

0.437

High

1250588

DPPA3
Developmental pluripotency-associated protein 3

1

2

High-throughput

0.437

High

1255351

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1276730

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1399088

SCLT1
Sodium channel and clathrin linker 1

1

2

High-throughput

0.437

High

1405556

TBX5
T-box transcription factor TBX5

1

1

High-throughput

0.437

High

1409547

B9D2
B9 domain-containing protein 2

1

1

High-throughput

0.437

High

1415478

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

142406

PEX7
Peroxisomal targeting signal 2 receptor

1

2

High-throughput

0.407

High

843937

HD
Huntingtin

3

0

High-throughput

0.346

High

1390814

CPNE2
Copine-2

3

0

High-throughput

0.345

High

1127677

KT33B
Keratin, type I cuticular Ha3-II

3

0

High-throughput

0.344

High

1394742

COG3
Conserved oligomeric Golgi complex subunit 3

3

0

High-throughput

0.344

High

1415475

MS18A
Protein Mis18-alpha

3

0

High-throughput

0.344

High

1383733

MIB2
E3 ubiquitin-protein ligase MIB2

2

0

High-throughput

0.328

High

1415474

FBX28
F-box only protein 28

2

0

High-throughput

0.328

High

353542

AGR2
Anterior gradient protein 2 homolog

2

0

High-throughput

0.316

High

190687

MRP5
ATP-binding cassette sub-family C member 5

1

0

High-throughput

0.279

Low

547477

DMD
Dystrophin

1

0

High-throughput

0.279

Low

1219196

SPAT1
Spermatogenesis-associated protein 1

1

0

High-throughput

0.279

Low

1380706

TOP1M
DNA topoisomerase I, mitochondrial

1

0

High-throughput

0.279

Low

1382659

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.279

Low

1384427

PF21A
PHD finger protein 21A

1

0

High-throughput

0.279

Low

1412280

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.279

Low

295431

SPI2
Serpin I2

1

0

High-throughput

0.269

Low

50011

A1A512
KIAA0355 protein

1

0

High-throughput

0.268

Low

50352

F168B
Myelin-associated neurite-outgrowth inhibitor

1

0

High-throughput

0.268

Low

50931

SYCE3
Synaptonemal complex central element protein 3

1

0

High-throughput

0.268

Low

85132

B7Z3E8
cDNA FLJ51208

1

0

High-throughput

0.268

Low

116365

H3BUJ7
Transcription factor E4F1

1

0

High-throughput

0.268

Low

131505

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.268

Low

185232

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.268

Low

217190

MS18B
Protein Mis18-beta

1

0

High-throughput

0.268

Low

252628

TSN2
Tetraspanin-2

1

0

High-throughput

0.268

Low

284871

TADA3
Transcriptional adapter 3

1

0

High-throughput

0.268

Low

298069

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.268

Low

298223

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.268

Low

329968

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.268

Low

391713

MT2
Metallothionein-2

1

0

High-throughput

0.268

Low

634932

BCL3
B-cell lymphoma 3 protein

1

0

High-throughput

0.268

Low

664530

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

0

High-throughput

0.268

Low

690722

AOFB
Amine oxidase [flavin-containing] B

1

0

High-throughput

0.268

Low

778769

PRS7
26S proteasome regulatory subunit 7

1

0

High-throughput

0.268

Low

867716

RGR
RPE-retinal G protein-coupled receptor

1

0

High-throughput

0.268

Low

884393

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.268

Low

943451

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

1

0

High-throughput

0.268

Low

1009805

IN35
Interferon-induced 35 kDa protein

1

0

High-throughput

0.268

Low

1055674

GABP1
GA-binding protein subunit beta-1

1

0

High-throughput

0.268

Low

1081596

BRME1
Break repair meiotic recombinase recruitment factor 1

1

0

High-throughput

0.268

Low

1103025

CENPR
Centromere protein R

1

0

High-throughput

0.268

Low

1108393

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.268

Low

1110782

NDF1
Neurogenic differentiation factor 1

1

0

High-throughput

0.268

Low

1132031

STAT4
Signal transducer and activator of transcription 4

1

0

High-throughput

0.268

Low

1240769

PMF1
Polyamine-modulated factor 1

1

0

High-throughput

0.268

Low

1251839

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.268

Low

1256463

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.268

Low

1280007

SPT12
Spermatogenesis-associated protein 12

1

0

High-throughput

0.268

Low

1287284

DPP9
Dipeptidyl peptidase 9

1

0

High-throughput

0.268

Low

1288018

YRDC
Threonylcarbamoyl-AMP synthase

1

0

High-throughput

0.268

Low

1292741

TRI69
E3 ubiquitin-protein ligase TRIM69

1

0

High-throughput

0.268

Low

1292831

TEN1L
CST complex subunit TEN1

1

0

High-throughput

0.268

Low

1292929

Q86WV8
TSC complex subunit 1

1

0

High-throughput

0.268

Low

1310750

ARCH
Protein archease

1

0

High-throughput

0.268

Low

1312168

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.268

Low

1313690

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.268

Low

1329270

MET27
Methyltransferase-like protein 27

1

0

High-throughput

0.268

Low

1336663

ICA1L
Islet cell autoantigen 1-like protein

1

0

High-throughput

0.268

Low

1337092

Q8NE08
COL25A1 protein

1

0

High-throughput

0.268

Low

1338216

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.268

Low

1381506

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.268

Low

1381835

TSACC
TSSK6-activating co-chaperone protein

1

0

High-throughput

0.268

Low

1386282

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.268

Low

1388030

ASB9
Ankyrin repeat and SOCS box protein 9

1

0

High-throughput

0.268

Low

1389334

REX1B
Required for excision 1-B domain-containing protein

1

0

High-throughput

0.268

Low

1390871

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.268

Low

1407806

HAUS7
HAUS augmin-like complex subunit 7

1

0

High-throughput

0.268

Low

1409762

PAIP2
Polyadenylate-binding protein-interacting protein 2

1

0

High-throughput

0.268

Low

1411053

Q9BR81
Protocadherin gamma subfamily C, 3

1

0

High-throughput

0.268

Low

1411967

PSF3
DNA replication complex GINS protein PSF3

1

0

High-throughput

0.268

Low

1413189

CSN4
COP9 signalosome complex subunit 4

1

0

High-throughput

0.268

Low

1414826

MTNA
Methylthioribose-1-phosphate isomerase

1

0

High-throughput

0.268

Low

1415070

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.268

Low

1415461

TEX12
Testis-expressed protein 12

1

0

High-throughput

0.268

Low

1415467

DSN1
Kinetochore-associated protein DSN1 homolog

1

0

High-throughput

0.268

Low

1415470

CD209
CD209 antigen

1

0

High-throughput

0.268

Low

1415471

AMBN
Ameloblastin

1

0

High-throughput

0.268

Low

1415473

GKN1
Gastrokine-1

1

0

High-throughput

0.268

Low

1415481

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.268

Low

1415482

PADI3
Protein-arginine deiminase type-3

1

0

High-throughput

0.268

Low

942854

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

1241946

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

1415468

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025