Protein: RSPO4
R-spondin-4 (Roof plate-specific spondin-4) (hRspo4)

Gene: RSPO4
Organism: Homo sapiens
Interactions: 16
UniProt ID: Q2I0M5

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0008201 - heparin binding
GO:0016055 - Wnt signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1177919

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

3

9

Small-scale

0.845

High

169573

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

7

High-throughput

0.553

High

291800

STK16
Serine/threonine-protein kinase 16

2

3

High-throughput

0.553

High

853801

MK09
Mitogen-activated protein kinase 9

2

3

High-throughput

0.553

High

1093624

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

1

High-throughput

0.553

High

1156080

ZNF77
Zinc finger protein 77

2

1

High-throughput

0.553

High

1177915

DHX57
Putative ATP-dependent RNA helicase DHX57

2

1

High-throughput

0.553

High

1177918

GUCD1
Protein GUCD1

2

1

High-throughput

0.553

High

1177921

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

1

High-throughput

0.553

High

1177922

ZN330
Zinc finger protein 330

2

1

High-throughput

0.553

High

1177924

X5D778
Ankyrin repeat domain 11 isoform A

1

4

High-throughput

0.470

High

1177916

ANR11
Ankyrin repeat domain-containing protein 11

1

3

High-throughput

0.439

High

1177914

KLH38
Kelch-like protein 38

2

0

High-throughput

0.316

High

1177917

PIHD2
PIH1 domain-containing protein 2

2

0

High-throughput

0.316

High

1177920

GBG13

2

0

High-throughput

0.316

High

1177923

GPSM3
G-protein-signaling modulator 3

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025