Protein: GPSM3
G-protein-signaling modulator 3 (Activator of G-protein signaling 4) (G18.1b) (Protein G18)

Gene: GPSM3
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q9Y4H4

Gene Ontology (top 5):
GO:0002690 - positive regulation of leukocyte chemotaxis
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0030695 - GTPase regulator activity
GO:0050729 - positive regulation of inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

989893

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

6

3

Small-scale

0.955

High

476064

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

5

3

High-throughput

0.926

High

418768

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

2

3

High-throughput

0.808

High

618505

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

1

3

High-throughput

0.691

High

990916

1433Z
14-3-3 protein zeta/delta

4

5

High-throughput

0.689

High

691579

1433T
14-3-3 protein theta

2

5

High-throughput

0.601

High

730395

1433B
14-3-3 protein beta/alpha

2

5

High-throughput

0.601

High

967068

1433G
14-3-3 protein gamma

2

5

High-throughput

0.601

High

1049947

1433F
14-3-3 protein eta

2

5

High-throughput

0.601

High

1491410

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.589

High

1006325

CTG1B
Cancer/testis antigen 1

2

0

High-throughput

0.580

High

1149285

NR0B2
Nuclear receptor subfamily 0 group B member 2

2

0

High-throughput

0.580

High

1250862

CRDL2
Chordin-like protein 2

2

0

High-throughput

0.580

High

1351816

ACMSD
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

2

0

High-throughput

0.580

High

1358942

SMIP5
Sperm-associated microtubule inner protein 5

2

0

High-throughput

0.580

High

1397007

BMF
Bcl-2-modifying factor

2

0

High-throughput

0.580

High

1408126

SPAG8
Sperm-associated antigen 8

2

0

High-throughput

0.580

High

1490809

STB5L
Syntaxin-binding protein 5-like

2

0

High-throughput

0.580

High

332348

ATE1
Arginyl-tRNA--protein transferase 1

2

0

High-throughput

0.576

High

972175

1433E
14-3-3 protein epsilon

2

0

High-throughput

0.576

High

1491411

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.556

High

1277100

PANKY
Photoreceptor ankyrin repeat protein

2

2

High-throughput

0.553

High

894264

MEOX2
Homeobox protein MOX-2

1

0

High-throughput

0.549

High

692172

MARK3
MAP/microtubule affinity-regulating kinase 3

1

2

High-throughput

0.536

High

843003

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

2

High-throughput

0.536

High

1270565

MARK2
Serine/threonine-protein kinase MARK2

1

2

High-throughput

0.536

High

1453878

MARK1
Serine/threonine-protein kinase MARK1

1

2

High-throughput

0.536

High

944116

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.515

High

334268

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

900242

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.513

High

1107512

BIRC2
Baculoviral IAP repeat-containing protein 2

1

0

High-throughput

0.513

High

1153799

NCOA1
Nuclear receptor coactivator 1

1

0

High-throughput

0.513

High

1459060

ADDG
Gamma-adducin

1

0

High-throughput

0.513

High

1491412

NFS1
Cysteine desulfurase

1

0

High-throughput

0.513

High

246198

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.493

High

361386

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.493

High

415959

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.493

High

637805

FLNA
Filamin-A

1

0

High-throughput

0.493

High

705622

GRN
Progranulin

1

0

High-throughput

0.493

High

1324617

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.493

High

1097178

MK07
Mitogen-activated protein kinase 7

1

1

High-throughput

0.481

High

375039

RASH
GTPase HRas

1

0

Small-scale

0.480

High

427

A0A087WSW0
Helt bHLH transcription factor

1

1

High-throughput

0.470

High

336517

SVIL
Supervillin

1

0

Small-scale

0.458

High

1438332

TENS1
Tensin-1

1

1

High-throughput

0.445

High

65227

HELT
Hairy and enhancer of split-related protein HELT

1

1

High-throughput

0.439

High

1433491

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.439

High

650507

FGFR3
Fibroblast growth factor receptor 3

1

0

Small-scale

0.438

High

575221

IDE
Insulin-degrading enzyme

1

0

High-throughput

0.426

High

1311135

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.426

High

1431680

GAN
Gigaxonin

1

0

High-throughput

0.426

High

1228531

TENS3
Tensin-3

1

1

High-throughput

0.407

High

221435

SPY3
Protein sprouty homolog 3

2

0

High-throughput

0.316

High

269425

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

600128

ZNF20
Zinc finger protein 20

2

0

High-throughput

0.316

High

686737

IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

2

0

High-throughput

0.316

High

1017566

PRR5
Proline-rich protein 5

2

0

High-throughput

0.316

High

1177923

RSPO4
R-spondin-4

2

0

High-throughput

0.316

High

1186937

KR194
Keratin-associated protein 19-4

2

0

High-throughput

0.316

High

1187766

KR133
Keratin-associated protein 13-3

2

0

High-throughput

0.316

High

1219917

CI057
Uncharacterized protein C9orf57

2

0

High-throughput

0.316

High

1234678

IQCE
IQ domain-containing protein E

2

0

High-throughput

0.316

High

1238983

UFSP1
Ufm1-specific protease 1

2

0

High-throughput

0.316

High

1278599

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

2

0

High-throughput

0.316

High

1307074

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.316

High

1315013

TEX11
Testis-expressed protein 11

2

0

High-throughput

0.316

High

1323669

BATF2
Basic leucine zipper transcriptional factor ATF-like 2

2

0

High-throughput

0.316

High

1347770

KC5S1
Uncharacterized protein KCNJ5-AS1

2

0

High-throughput

0.316

High

1359998

MB3L1
Methyl-CpG-binding domain protein 3-like 1

2

0

High-throughput

0.316

High

1361045

P66B
Transcriptional repressor p66-beta

2

0

High-throughput

0.316

High

1361056

ASB15
Ankyrin repeat and SOCS box protein 15

2

0

High-throughput

0.316

High

1385005

COA7
Cytochrome c oxidase assembly factor 7

2

0

High-throughput

0.316

High

1450673

F86C1
Putative protein FAM86C1P

2

0

High-throughput

0.316

High

1454008

ZN581
Zinc finger protein 581

2

0

High-throughput

0.316

High

1272332

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

2

0

High-throughput

0.313

High

1403215

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

2

0

High-throughput

0.313

High

283580

TAD2A
Transcriptional adapter 2-alpha

1

0

High-throughput

0.299

High

1330117

USBP1
Harmonin-binding protein USHBP1

1

0

High-throughput

0.299

High

210369

PHF1
PHD finger protein 1

1

0

High-throughput

0.279

Low

281801

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

High-throughput

0.279

Low

289829

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.279

Low

823923

PBX2
Pre-B-cell leukemia transcription factor 2

1

0

High-throughput

0.279

Low

1235700

NIPBL
Nipped-B-like protein

1

0

High-throughput

0.279

Low

1280984

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

0

High-throughput

0.279

Low

1311899

DHX40
Probable ATP-dependent RNA helicase DHX40

1

0

High-throughput

0.279

Low

1315444

P20D2
Xaa-Arg dipeptidase

1

0

High-throughput

0.279

Low

1322515

PUSL1
tRNA pseudouridine synthase-like 1

1

0

High-throughput

0.279

Low

1358689

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

0

High-throughput

0.279

Low

1400954

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.279

Low

1438293

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.279

Low

1449017

F1142
Protein FAM114A2

1

0

High-throughput

0.279

Low

1452611

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.279

Low

1491413

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.279

Low

301777

WFS1
Wolframin

1

0

High-throughput

0.268

Low

1031971

NC2B
Protein Dr1

1

0

High-throughput

0.268

Low

1096288

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.268

Low

1196956

HIG2B
HIG1 domain family member 2B

1

0

High-throughput

0.268

Low

1491173

RNF11
RING finger protein 11

1

0

High-throughput

0.268

Low

1352412

RHBL4
Rhomboid-related protein 4

1

0

Small-scale

0.249

Low

1095235

MTAP
S-methyl-5'-thioadenosine phosphorylase

1

0

High-throughput

0.232

Low

1143881

TCAL1
Transcription elongation factor A protein-like 1

1

0

High-throughput

0.232

Low

1347815

SPT20
Spermatogenesis-associated protein 20

1

0

High-throughput

0.232

Low

1491036

MEMO1
Protein MEMO1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025