HitPredict

Interactor 1: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Interactor 2: SHC4 (Q6S5L8)
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)
Gene: SHC4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 920 Hs			1 630
+	Hs
		519772 ANDR_HUMAN (1-920): 0: 966: 100.00		SHC1_HUMAN (26-620): 3.38e-155: 461: 45.40
+	Hs
		520232 ANDR_HUMAN (1-920): 0: 966: 100.00		SHC3_HUMAN (24-621): 3.6e-145: 435: 42.88
+	Hs
		520202 ANDR_HUMAN (1-920): 0: 966: 100.00		SH2D3_HUMAN (331-619): 7.21e-45: 173: 17.16
+	Hs
		462956 ANDR_HUMAN (1-920): 0: 966: 100.00		YES_HUMAN (367-628): 1.09e-43: 166: 16.12
+	Hs
		520073 ANDR_HUMAN (1-920): 0: 966: 100.00		SHB_HUMAN (356-617): 6.01e-44: 166: 20.73
+	Hs
		519699 ANDR_HUMAN (1-920): 0: 966: 100.00		SRC_HUMAN (385-628): 1.61e-43: 165: 14.77
+	Hs
		456086 ANDR_HUMAN (1-920): 0: 966: 100.00		FES_HUMAN (384-629): 9.32e-42: 164: 20.16
+	Hs
		519718 ANDR_HUMAN (1-920): 0: 966: 100.00		PLCG2_HUMAN (328-630): 7.35e-39: 156: 15.79
+	Hs
		519764 ANDR_HUMAN (1-920): 0: 966: 100.00		P85A_HUMAN (521-622): 5.05e-20: 96.7: 25.47
+	Hs
		519921 ANDR_HUMAN (1-920): 0: 966: 100.00		GRB2_HUMAN (520-616): 5.13e-14: 73.4: 30.48
+	Hs
		395548 ESR1_HUMAN (378-904): 7.63e-136: 420: 22.20		SHC1_HUMAN (26-620): 3.38e-155: 461: 45.40
+	Hs
		395341 ESR1_HUMAN (378-904): 7.63e-136: 420: 22.20		YES_HUMAN (367-628): 1.09e-43: 166: 16.12
+	Hs
		395400 ESR1_HUMAN (378-904): 7.63e-136: 420: 22.20		SRC_HUMAN (385-628): 1.61e-43: 165: 14.77
+	Mm
		431322 ESR1_MOUSE (378-904): 2.51e-129: 403: 21.30		SRC_MOUSE (385-628): 5.82e-45: 169: 15.59
+	Rn
		439610 ESR1_RAT (378-904): 2.2e-130: 406: 20.94		SRC_RAT (394-628): 5.25e-43: 164: 16.14
+	Hs
		403785 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		SRC_HUMAN (385-628): 1.61e-43: 165: 14.77
+	Hs
		557079 RXRA_HUMAN (392-902): 7.08e-120: 374: 19.84		SRC_HUMAN (385-628): 1.61e-43: 165: 14.77
+	Hs
		463183 ESR2_HUMAN (435-912): 2.49e-116: 367: 21.51		YES_HUMAN (367-628): 1.09e-43: 166: 16.12
+	Hs
		395537 ESR1_HUMAN (378-904): 7.63e-136: 420: 22.20		P85A_HUMAN (521-622): 5.05e-20: 96.7: 25.47
+	Hs
		625764 RXRA_HUMAN (392-902): 7.08e-120: 374: 19.84		P85A_HUMAN (521-622): 5.05e-20: 96.7: 25.47