Protein: SHC3
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)

Gene: SHC3
Organism: Homo sapiens
Interactions: 64
UniProt ID: Q92529

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
GO:0007173 - epidermal growth factor receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363646

EGFR
Epidermal growth factor receptor

6

20

Small-scale

0.946

High

1159521

NTRK2
BDNF/NT-3 growth factors receptor

3

20

Small-scale

0.829

High

1247473

SHC4
SHC-transforming protein 4

2

19

High-throughput

0.789

High

410971

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

641639

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

422748

A4
Amyloid-beta precursor protein

2

20

Small-scale

0.776

High

412347

NTRK1
High affinity nerve growth factor receptor

2

20

Small-scale

0.754

High

1363740

ALK
ALK tyrosine kinase receptor

2

20

Small-scale

0.754

High

472106

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

532094

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

1146077

K1H1
Keratin, type I cuticular Ha1

3

20

High-throughput

0.675

High

1230175

K1C40
Keratin, type I cytoskeletal 40

3

20

High-throughput

0.675

High

1363731

SH3G3
Endophilin-A3

1

20

High-throughput

0.656

High

1145757

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

401221

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

19

High-throughput

0.618

High

699814

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

849077

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

Small-scale

0.618

High

227252

KRT86
Keratin, type II cuticular Hb6

2

20

High-throughput

0.606

High

286695

STX11
Syntaxin-11

2

6

High-throughput

0.606

High

300448

KRT34
Keratin, type I cuticular Ha4

2

20

High-throughput

0.606

High

725425

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

10

High-throughput

0.606

High

820703

CEAM6
Cell adhesion molecule CEACAM6

2

16

High-throughput

0.606

High

1048943

REL
Proto-oncogene c-Rel

2

8

High-throughput

0.606

High

1090826

TRAF2
TNF receptor-associated factor 2

2

20

High-throughput

0.606

High

1093897

TRAF1
TNF receptor-associated factor 1

2

12

High-throughput

0.606

High

1127668

KT33B
Keratin, type I cuticular Ha3-II

2

20

High-throughput

0.606

High

1230336

K1C39
Keratin, type I cytoskeletal 39

2

20

High-throughput

0.606

High

1272287

DOK3
Docking protein 3

2

20

High-throughput

0.606

High

1272504

CSN6
COP9 signalosome complex subunit 6

2

2

High-throughput

0.606

High

1287711

LPP60
60 kDa lysophospholipase

2

11

High-throughput

0.606

High

1363728

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.606

High

1363730

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

2

10

High-throughput

0.606

High

1363739

VPS28
Vacuolar protein sorting-associated protein 28 homolog

2

1

High-throughput

0.606

High

874180

PSMD8
26S proteasome non-ATPase regulatory subunit 8

2

0

High-throughput

0.580

High

1240759

PMF1
Polyamine-modulated factor 1

2

0

High-throughput

0.580

High

1363729

BMF
Bcl-2-modifying factor

2

0

High-throughput

0.580

High

1363732

CDCA4
Cell division cycle-associated protein 4

2

0

High-throughput

0.580

High

1363734

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

2

0

High-throughput

0.580

High

1363736

SMYD3
Histone-lysine N-methyltransferase SMYD3

2

0

High-throughput

0.580

High

1363738

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.580

High

67692

RHG32
Rho GTPase-activating protein 32

1

20

Small-scale

0.561

High

65118

GG6L9
Golgin subfamily A member 6-like protein 9

2

20

High-throughput

0.553

High

666877

CCNC
Cyclin-C

2

6

High-throughput

0.553

High

977138

YPEL5
Protein yippee-like 5

2

1

High-throughput

0.553

High

1213515

UBAP2
Ubiquitin-associated protein 2

2

13

High-throughput

0.553

High

1258154

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

3

High-throughput

0.553

High

1330039

USBP1
Harmonin-binding protein USHBP1

2

19

High-throughput

0.553

High

1336425

PNMA1
Paraneoplastic antigen Ma1

2

7

High-throughput

0.553

High

1363733

TRI54
Tripartite motif-containing protein 54

2

20

High-throughput

0.553

High

1363737

ANR10
Ankyrin repeat domain-containing protein 10

2

11

High-throughput

0.553

High

1363741

TRI35
E3 ubiquitin-protein ligase TRIM35

2

13

High-throughput

0.553

High

520232

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

1106495

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.536

High

1063483

GOGA2
Golgin subfamily A member 2

1

18

High-throughput

0.523

High

104290

F5H5M1
SHC adaptor protein 4

1

19

High-throughput

0.514

High

1363727

TSC1
Hamartin

1

20

High-throughput

0.481

High

635903

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

4

Small-scale

0.479

High

642996

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

14

Small-scale

0.479

High

1024729

VIGLN
Vigilin

1

12

High-throughput

0.479

High

1137901

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

1292916

Q86WV8
TSC complex subunit 1

1

1

High-throughput

0.470

High

959505

YPEL3
Protein yippee-like 3

1

1

High-throughput

0.439

High

1356616

CT55
Cancer/testis antigen 55

2

0

High-throughput

0.316

High

1363735

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025