Protein: DCAM
S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain]

Gene: DCAM, AMD1
Organism: Homo sapiens
Interactions: 57
UniProt ID: P17707

Gene Ontology (top 5):
GO:0004014 - adenosylmethionine decarboxylase activity
GO:0005829 - cytosol
GO:0006595 - polyamine metabolic process
GO:0006597 - spermine biosynthetic process
GO:0008295 - spermidine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

607682

DCAM
S-adenosylmethionine decarboxylase proenzyme

3

3

Small-scale

0.836

High

607687

SHC1
SHC-transforming protein 1

2

3

High-throughput

0.628

High

607721

GLTP
Glycolipid transfer protein

2

1

High-throughput

0.628

High

351853

BMP15
Bone morphogenetic protein 15

3

1

High-throughput

0.609

High

607724

FBX4
F-box only protein 4

2

0

High-throughput

0.602

High

607703

THAP4
Peroxynitrite isomerase THAP4

2

0

High-throughput

0.580

High

607683

BMP7
Bone morphogenetic protein 7

2

1

High-throughput

0.558

High

607698

SHC4
SHC-transforming protein 4

2

3

High-throughput

0.558

High

415334

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

607699

DPP8
Dipeptidyl peptidase 8

1

0

High-throughput

0.513

High

607707

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.513

High

607711

TCF25
Ribosome quality control complex subunit TCF25

1

0

High-throughput

0.513

High

607718

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.513

High

607720

FGOP2
FGFR1 oncogene partner 2

1

0

High-throughput

0.513

High

64791

EPAB2
Embryonic polyadenylate-binding protein 2

1

1

High-throughput

0.489

High

607689

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

607693

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

607713

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

1

0

Small-scale

0.458

High

607722

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

259405

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.437

High

607691

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.437

High

607694

H90B4
Putative heat shock protein HSP 90-beta 4

1

0

High-throughput

0.426

High

104288

F5H5M1
SHC adaptor protein 4

1

3

High-throughput

0.407

High

607684

PACA
Pituitary adenylate cyclase-activating polypeptide

3

0

High-throughput

0.347

High

607688

PRELP
Prolargin

3

0

High-throughput

0.347

High

607700

DOK3
Docking protein 3

3

0

High-throughput

0.347

High

607726

CLC11
C-type lectin domain family 11 member A

3

0

High-throughput

0.347

High

607727

KPTN
KICSTOR complex protein kaptin

3

0

High-throughput

0.347

High

607696

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

3

0

High-throughput

0.334

High

342422

RPP29
Ribonuclease P protein subunit p29

2

0

High-throughput

0.328

High

377048

COLI
Pro-opiomelanocortin

2

0

High-throughput

0.328

High

607701

MISP
Mitotic interactor and substrate of PLK1

2

0

High-throughput

0.328

High

607705

SNX21
Sorting nexin-21

2

0

High-throughput

0.328

High

607708

HDA11
Histone deacetylase 11

2

0

High-throughput

0.328

High

607710

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.328

High

607723

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

607706

TIP39
Tuberoinfundibular peptide of 39 residues

2

0

High-throughput

0.319

High

607704

DNS2B
Deoxyribonuclease-2-beta

2

0

High-throughput

0.318

High

607712

RTBDN
Retbindin

2

0

High-throughput

0.318

High

154626

ARI1A
AT-rich interactive domain-containing protein 1A

1

0

High-throughput

0.279

Low

607685

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

0

High-throughput

0.279

Low

607686

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.279

Low

607690

MFAP5
Microfibrillar-associated protein 5

1

0

High-throughput

0.279

Low

607692

SSX2
Protein SSX2

1

0

High-throughput

0.279

Low

607695

BEX5
Protein BEX5

1

0

High-throughput

0.279

Low

607702

RP25L
Ribonuclease P protein subunit p25-like protein

1

0

High-throughput

0.279

Low

607709

BORC8
BLOC-1-related complex subunit 8

1

0

High-throughput

0.279

Low

607715

CSTFT
Cleavage stimulation factor subunit 2 tau variant

1

0

High-throughput

0.279

Low

607716

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.279

Low

607717

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.279

Low

607719

CTSRZ
Cation channel sperm-associated auxiliary subunit zeta

1

0

High-throughput

0.279

Low

607725

PA2GD
Group IID secretory phospholipase A2

1

0

High-throughput

0.279

Low

607697

ASTL
Astacin-like metalloendopeptidase

1

0

High-throughput

0.249

Low

607714

NYX
Nyctalopin

1

0

High-throughput

0.249

Low

505936

MYZAP
Myocardial zonula adherens protein

1

0

High-throughput

0.232

Low

505993

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025