Protein: MCAF1
Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621)

Gene: MCAF1, ATF7IP
Organism: Homo sapiens
Interactions: 127
UniProt ID: Q6VMQ6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003712 - transcription coregulator activity
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1139744

SETB1
Histone-lysine N-methyltransferase SETDB1

6

13

Small-scale

0.735

High

464991

SP1
Transcription factor Sp1

4

8

Small-scale

0.703

High

822725

VHL
von Hippel-Lindau disease tumor suppressor

4

1

Small-scale

0.691

High

1250475

MBD1
Methyl-CpG-binding domain protein 1

3

7

Small-scale

0.672

High

1250450

AL14E
ARL14 effector protein

3

3

High-throughput

0.671

High

1250449

RYBP
RING1 and YY1-binding protein

3

2

High-throughput

0.667

High

284838

TADA3
Transcriptional adapter 3

3

0

High-throughput

0.638

High

216470

SUV91
Histone-lysine N-methyltransferase SUV39H1

2

5

High-throughput

0.628

High

1250446

YAF2
YY1-associated factor 2

2

2

High-throughput

0.628

High

1250455

EHMT2
Histone-lysine N-methyltransferase EHMT2

2

14

High-throughput

0.606

High

964338

SUMO2
Small ubiquitin-related modifier 2

2

6

High-throughput

0.602

High

1250456

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

11

High-throughput

0.601

High

1106586

SMAD4
Mothers against decapentaplegic homolog 4

2

5

High-throughput

0.595

High

1250474

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

Small-scale

0.549

High

300777

KRT38
Keratin, type I cuticular Ha8

1

3

High-throughput

0.536

High

384457

CRYAA
Alpha-crystallin A chain

1

3

High-throughput

0.536

High

387123

TNNC2
Troponin C, skeletal muscle

1

7

High-throughput

0.536

High

691778

MK03
Mitogen-activated protein kinase 3

1

4

High-throughput

0.536

High

1004738

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.536

High

1014135

CBX1
Chromobox protein homolog 1

1

8

High-throughput

0.536

High

1099705

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

2

High-throughput

0.536

High

1152367

ZN174
Zinc finger protein 174

1

1

High-throughput

0.536

High

1156300

HSPB2
Heat shock protein beta-2

1

3

High-throughput

0.536

High

1250448

PIAS4
E3 SUMO-protein ligase PIAS4

1

3

High-throughput

0.536

High

1017710

PR20A
Proline-rich protein 20A

2

1

High-throughput

0.533

High

1037223

H11
Histone H1.1

1

5

High-throughput

0.515

High

1136024

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

1217067

MCAF2
Activating transcription factor 7-interacting protein 2

1

0

High-throughput

0.513

High

1250473

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.513

High

481316

HMGB1
High mobility group protein B1

1

20

Small-scale

0.508

High

1017595

PR20E
Proline-rich protein 20E

2

1

High-throughput

0.504

High

1250468

DISC1
Disrupted in schizophrenia 1 protein

1

0

Small-scale

0.486

High

593138

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

High-throughput

0.481

High

993624

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

1085443

SRBP2
Sterol regulatory element-binding protein 2

1

16

High-throughput

0.481

High

1250453

CBP
CREB-binding protein

1

17

Small-scale

0.481

High

143065

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

190966

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

9

High-throughput

0.479

High

214495

HXA2
Homeobox protein Hox-A2

1

14

High-throughput

0.479

High

339784

KLF8
Krueppel-like factor 8

1

19

High-throughput

0.479

High

414058

P53
Cellular tumor antigen p53

1

13

High-throughput

0.479

High

474075

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

540894

ERG
Transcriptional regulator ERG

1

19

High-throughput

0.479

High

588973

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

622826

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

6

Small-scale

0.479

High

635197

HNF1A
Hepatocyte nuclear factor 1-alpha

1

7

High-throughput

0.479

High

667345

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

Small-scale

0.479

High

675554

TYY1
Transcriptional repressor protein YY1

1

6

High-throughput

0.479

High

708981

T2EB
Transcription initiation factor IIE subunit beta

1

2

Small-scale

0.479

High

768480

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

775868

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

776089

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

833974

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

944687

KLF3
Krueppel-like factor 3

1

18

High-throughput

0.479

High

1033033

EWS
RNA-binding protein EWS

1

10

High-throughput

0.479

High

1087816

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1097369

CBX3
Chromobox protein homolog 3

1

8

High-throughput

0.479

High

1133481

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1250443

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

1250445

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

1250447

SLX4
Structure-specific endonuclease subunit SLX4

1

18

High-throughput

0.479

High

1250451

NUP43
Nucleoporin Nup43

1

17

High-throughput

0.479

High

1250452

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1250457

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

1250470

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

1250472

ZMYM2
Zinc finger MYM-type protein 2

1

3

High-throughput

0.479

High

1250480

KLF12
Krueppel-like factor 12

1

19

High-throughput

0.479

High

1250482

SAR1B
Small COPII coat GTPase SAR1B

1

4

High-throughput

0.479

High

611678

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

0

Small-scale

0.458

High

708902

T2EA
General transcription factor IIE subunit 1

1

0

Small-scale

0.458

High

1250483

CDY2
Testis-specific chromodomain protein Y 2

1

0

High-throughput

0.458

High

183268

LAMA5
Laminin subunit alpha-5

1

3

High-throughput

0.457

High

278113

FLNB
Filamin-B

1

8

High-throughput

0.457

High

431578

AP2A
Transcription factor AP-2-alpha

1

1

High-throughput

0.457

High

777710

VGFR3
Vascular endothelial growth factor receptor 3

1

10

High-throughput

0.457

High

923604

TTC3
E3 ubiquitin-protein ligase TTC3

1

11

High-throughput

0.457

High

952910

ACTB
Actin, cytoplasmic 1

1

14

High-throughput

0.457

High

959833

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.457

High

993222

ACTG
Actin, cytoplasmic 2

1

14

High-throughput

0.457

High

1022585

PKD1
Polycystin-1

1

2

High-throughput

0.457

High

1028800

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

11

High-throughput

0.457

High

1056804

FMR1
Fragile X messenger ribonucleoprotein 1

1

13

High-throughput

0.457

High

1062171

PCDH1
Protocadherin-1

1

2

High-throughput

0.457

High

1112245

PEX6
Peroxisomal ATPase PEX6

1

4

High-throughput

0.457

High

1129327

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

9

High-throughput

0.457

High

1156073

ZBTB6
Zinc finger and BTB domain-containing protein 6

1

5

High-throughput

0.457

High

1195518

SVEP1
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

1

2

High-throughput

0.457

High

1230721

Z518A
Zinc finger protein 518A

1

1

High-throughput

0.457

High

1248224

CSPG4
Chondroitin sulfate proteoglycan 4

1

2

High-throughput

0.457

High

1250459

CP250
Centrosome-associated protein CEP250

1

10

High-throughput

0.457

High

1250462

ZN350
Zinc finger protein 350

1

1

High-throughput

0.457

High

1250463

KI13A
Kinesin-like protein KIF13A

1

6

High-throughput

0.457

High

1250464

SENP3
Sentrin-specific protease 3

1

2

High-throughput

0.457

High

1250466

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.457

High

1250467

HEYL
Hairy/enhancer-of-split related with YRPW motif-like protein

1

1

High-throughput

0.457

High

1250478

DMTF1
Cyclin-D-binding Myb-like transcription factor 1

1

6

High-throughput

0.457

High

1250484

PIAS3
E3 SUMO-protein ligase PIAS3

1

3

High-throughput

0.457

High

1250444

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.445

High

1250458

MTNA
Methylthioribose-1-phosphate isomerase

1

0

High-throughput

0.438

High

1250481

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

0

High-throughput

0.438

High

1071168

ARL16
ADP-ribosylation factor-like protein 16

1

2

High-throughput

0.437

High

1250442

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

471596

CO4A2

1

1

High-throughput

0.417

High

535857

LAMC1
Laminin subunit gamma-1

1

2

High-throughput

0.417

High

845689

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.417

High

937552

CAD11
Cadherin-11

1

4

High-throughput

0.417

High

1098513

PAPP1
Pappalysin-1

1

4

High-throughput

0.417

High

1157276

LAMA4
Laminin subunit alpha-4

1

2

High-throughput

0.417

High

1248510

SUSD1
Sushi domain-containing protein 1

1

7

High-throughput

0.417

High

1250460

PAPP2
Pappalysin-2

1

3

High-throughput

0.417

High

1250469

Q9NXG9
cDNA FLJ20259 fis, clone COLF7443

1

3

High-throughput

0.417

High

1250471

RRBP1
Ribosome-binding protein 1

1

13

High-throughput

0.417

High

1250477

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

11

High-throughput

0.417

High

62544

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

379364

IGHG2
Immunoglobulin heavy constant gamma 2

1

2

High-throughput

0.407

High

287314

RF1M
Peptide chain release factor 1, mitochondrial

1

0

High-throughput

0.279

Low

329551

STBD1
Starch-binding domain-containing protein 1

1

0

High-throughput

0.238

Low

380078

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.238

Low

591204

ANPRA
Atrial natriuretic peptide receptor 1

1

0

High-throughput

0.238

Low

1143625

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.238

Low

1158730

PSG3
Pregnancy-specific beta-1-glycoprotein 3

1

0

High-throughput

0.238

Low

1160915

PRSS8
Prostasin

1

0

High-throughput

0.238

Low

1250454

PKHB2
Pleckstrin homology domain-containing family B member 2

1

0

High-throughput

0.238

Low

1250461

CADM1
Cell adhesion molecule 1

1

0

High-throughput

0.238

Low

1250465

EPG5
Ectopic P granules protein 5 homolog

1

0

High-throughput

0.238

Low

1250476

S12A4
Solute carrier family 12 member 4

1

0

High-throughput

0.238

Low

1250479

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025