Protein: FUCO
Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1)

Gene: FUCO, FUCA1
Organism: Homo sapiens
Interactions: 26
UniProt ID: P04066

Gene Ontology (top 5):
GO:0004560 - alpha-L-fucosidase activity
GO:0005576 - extracellular region
GO:0005737 - cytoplasm
GO:0005764 - lysosome
GO:0006004 - fucose metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

402452

MARK2
Serine/threonine-protein kinase MARK2

4

2

High-throughput

0.699

High

402459

FUCO2
Plasma alpha-L-fucosidase

1

0

High-throughput

0.656

High

402453

SUMF1
Formylglycine-generating enzyme

2

0

High-throughput

0.602

High

402456

CIB1
Calcium and integrin-binding protein 1

2

0

High-throughput

0.580

High

402463

UBQL2
Ubiquilin-2

2

0

High-throughput

0.580

High

402449

KPCD1
Serine/threonine-protein kinase D1

2

1

High-throughput

0.574

High

402447

CUL3
Cullin-3

1

1

High-throughput

0.536

High

402464

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.513

High

317392

KPCD3
Serine/threonine-protein kinase D3

1

1

High-throughput

0.489

High

402446

VAV2
Guanine nucleotide exchange factor VAV2

1

0

High-throughput

0.486

High

402444

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

240452

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

402445

MARK3
MAP/microtubule affinity-regulating kinase 3

1

2

High-throughput

0.479

High

402461

MARK1
Serine/threonine-protein kinase MARK1

1

2

High-throughput

0.479

High

402455

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.460

High

402443

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.458

High

402450

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

185339

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.457

High

402460

FBX6
F-box only protein 6

1

2

High-throughput

0.445

High

402462

UBP35
Ubiquitin carboxyl-terminal hydrolase 35

1

1

Small-scale

0.437

High

289837

TIPRL
TIP41-like protein

2

0

High-throughput

0.328

High

402448

PDIA5
Protein disulfide-isomerase A5

2

0

High-throughput

0.328

High

402457

CHCH5
Coiled-coil-helix-coiled-coil-helix domain-containing protein 5

2

0

High-throughput

0.328

High

402458

MED10
Mediator of RNA polymerase II transcription subunit 10

2

0

High-throughput

0.316

High

402451

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.251

Low

402454

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025