Protein: SUMF1
Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1)

Gene: SUMF1
Organism: Homo sapiens
Interactions: 50
UniProt ID: Q8NBK3

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0016020 - membrane
GO:0016491 - oxidoreductase activity
GO:0018158 - protein oxidation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1333558

SUMF2
Inactive C-alpha-formylglycine-generating enzyme 2

1

5

Small-scale

0.715

High

582349

ARSA
Arylsulfatase A

3

13

High-throughput

0.667

High

1333629

SUMF1
Formylglycine-generating enzyme

1

5

Small-scale

0.665

High

647383

IDS
Iduronate 2-sulfatase

4

13

Small-scale

0.630

High

476507

STS
Steryl-sulfatase

2

13

High-throughput

0.628

High

1333631

ARSG
Arylsulfatase G

2

13

High-throughput

0.628

High

1333634

ERP44
Endoplasmic reticulum resident protein 44

2

1

High-throughput

0.628

High

402453

FUCO
Tissue alpha-L-fucosidase

2

0

High-throughput

0.602

High

1333638

STIM2
Stromal interaction molecule 2

2

0

High-throughput

0.602

High

1333632

CTRC
Chymotrypsin-C

3

1

High-throughput

0.599

High

907219

SPHM
N-sulphoglucosamine sulphohydrolase

3

13

Small-scale

0.599

High

584968

GNS
N-acetylglucosamine-6-sulfatase

2

13

High-throughput

0.574

High

593262

LIPP
Pancreatic triacylglycerol lipase

2

1

High-throughput

0.574

High

756570

GALNS
N-acetylgalactosamine-6-sulfatase

2

13

High-throughput

0.549

High

296623

TNF13
Tumor necrosis factor ligand superfamily member 13

1

1

High-throughput

0.536

High

907247

ARSL
Arylsulfatase L

1

13

High-throughput

0.536

High

932344

ARSF
Arylsulfatase F

1

13

High-throughput

0.536

High

1030191

IL5RA
Interleukin-5 receptor subunit alpha

1

1

High-throughput

0.536

High

1248913

ARSK
Arylsulfatase K

1

13

High-throughput

0.536

High

1310998

SULF2
Extracellular sulfatase Sulf-2

1

13

High-throughput

0.536

High

1034775

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

1333641

MSRA
Mitochondrial peptide methionine sulfoxide reductase

1

0

High-throughput

0.513

High

1333642

FBX2
F-box only protein 2

1

0

High-throughput

0.513

High

449614

KLK1
Kallikrein-1

1

4

High-throughput

0.489

High

458018

TRY2
Trypsin-2

1

3

High-throughput

0.489

High

570697

EDN3
Endothelin-3

1

1

High-throughput

0.489

High

628427

KLK2
Kallikrein-2

1

4

High-throughput

0.489

High

1333636

KLK15
Kallikrein-15

1

4

High-throughput

0.489

High

1333643

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

1

High-throughput

0.489

High

1333644

LIPG
Endothelial lipase

1

1

High-throughput

0.489

High

218473

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

1254670

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1160417

TAZ
Tafazzin

3

0

High-throughput

0.347

High

168430

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.279

Low

224503

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.279

Low

282849

CRLF1
Cytokine receptor-like factor 1

1

0

High-throughput

0.279

Low

327072

NXPH3
Neurexophilin-3

1

0

High-throughput

0.279

Low

341334

ECEL1
Endothelin-converting enzyme-like 1

1

0

High-throughput

0.279

Low

342621

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

378294

IFN21
Interferon alpha-21

1

0

High-throughput

0.279

Low

567919

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.279

Low

1248561

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.279

Low

1333630

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.279

Low

1333633

OMD
Osteomodulin

1

0

High-throughput

0.279

Low

1333635

CST11
Cystatin-11

1

0

High-throughput

0.279

Low

1333637

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.279

Low

1333639

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

1333640

BTNL2
Butyrophilin-like protein 2

1

0

High-throughput

0.279

Low

508285

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025