Protein: FUCO2
Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2)

Gene: FUCO2, FUCA2
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q9BTY2

Gene Ontology (top 5):
GO:0004560 - alpha-L-fucosidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005764 - lysosome
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

699056

CALX
Calnexin

3

1

High-throughput

0.675

High

402459

FUCO
Tissue alpha-L-fucosidase

1

0

High-throughput

0.656

High

535474

BIP
Endoplasmic reticulum chaperone BiP

2

0

High-throughput

0.602

High

1413827

MA2B2
Epididymis-specific alpha-mannosidase

2

0

High-throughput

0.602

High

354836

WNT11
Protein Wnt-11

2

0

High-throughput

0.580

High

1180121

VWC2
Brorin

2

0

High-throughput

0.580

High

1413821

FBX6
F-box only protein 6

3

2

High-throughput

0.578

High

885385

HXA1
Homeobox protein Hox-A1

2

1

High-throughput

0.553

High

1235894

KRA53
Keratin-associated protein 5-3

2

2

High-throughput

0.553

High

1410087

KR412
Keratin-associated protein 4-12

2

1

High-throughput

0.553

High

1114166

CUL3
Cullin-3

1

1

High-throughput

0.536

High

1413824

GPC5B
G-protein coupled receptor family C group 5 member B

1

0

High-throughput

0.518

High

1101186

CLN3
Battenin

1

0

High-throughput

0.513

High

1413826

RAB21
Ras-related protein Rab-21

1

0

High-throughput

0.513

High

1413823

NRBP2
Nuclear receptor-binding protein 2

1

1

High-throughput

0.489

High

188984

TMPS2
Transmembrane protease serine 2

1

0

High-throughput

0.458

High

218705

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

185976

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.457

High

949765

KR101
Keratin-associated protein 10-1

1

1

High-throughput

0.439

High

242771

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.437

High

702411

CYTD
Cystatin-D

1

0

High-throughput

0.426

High

1360147

PATE1
Prostate and testis expressed protein 1

1

0

High-throughput

0.426

High

170939

CLGN
Calmegin

1

1

High-throughput

0.407

High

1413822

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

1

High-throughput

0.407

High

1413825

FBX2
F-box only protein 2

1

2

High-throughput

0.407

High

1357369

NAT14
Probable N-acetyltransferase 14

2

0

High-throughput

0.328

High

1389721

TV23C
Golgi apparatus membrane protein TVP23 homolog C

2

0

High-throughput

0.328

High

894129

MEOX2
Homeobox protein MOX-2

2

0

High-throughput

0.327

High

164634

TNPO2
Transportin-2

2

0

High-throughput

0.316

High

1109373

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

High-throughput

0.316

High

1214001

LCE1E
Late cornified envelope protein 1E

2

0

High-throughput

0.316

High

1214278

LCE1A
Late cornified envelope protein 1A

2

0

High-throughput

0.316

High

1214319

LCE1B
Late cornified envelope protein 1B

2

0

High-throughput

0.316

High

1215115

LCE4A
Late cornified envelope protein 4A

2

0

High-throughput

0.316

High

1257643

KRA52
Keratin-associated protein 5-2

2

0

High-throughput

0.316

High

1277907

NUFP2
FMR1-interacting protein NUFIP2

2

0

High-throughput

0.316

High

1399218

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

186937

GPR37
Prosaposin receptor GPR37

1

0

High-throughput

0.282

High

180376

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.279

Low

462804

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.279

Low

942290

CLD12
Claudin-12

1

0

High-throughput

0.279

Low

1153481

EFNB3
Ephrin-B3

1

0

High-throughput

0.279

Low

1160840

NFIL3
Nuclear factor interleukin-3-regulated protein

1

0

High-throughput

0.279

Low

1310365

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

106577

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1324171

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

1335700

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025