Protein: MED10
Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) (Transformation-related gene 17 protein) (TRG-17) (Transformation-related gene 20 protein) (TRG-20)

Gene: MED10
Organism: Homo sapiens
Interactions: 113
UniProt ID: Q9BTT4

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

49008

MED19
Mediator of RNA polymerase II transcription subunit 19

11

1

Small-scale

0.980

High

219511

MED7
Mediator of RNA polymerase II transcription subunit 7

10

6

Small-scale

0.975

High

1372187

MED12
Mediator of RNA polymerase II transcription subunit 12

10

2

Small-scale

0.975

High

287814

MED6
Mediator of RNA polymerase II transcription subunit 6

8

4

Small-scale

0.970

High

1108390

MED21
Mediator of RNA polymerase II transcription subunit 21

8

1

Small-scale

0.969

High

239612

MED14
Mediator of RNA polymerase II transcription subunit 14

7

4

Small-scale

0.962

High

1295672

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

2

High-throughput

0.789

High

881595

CDK8
Cyclin-dependent kinase 8

13

4

Small-scale

0.761

High

1413633

MED17
Mediator of RNA polymerase II transcription subunit 17

12

1

Small-scale

0.760

High

1413626

MED18
Mediator of RNA polymerase II transcription subunit 18

10

1

Small-scale

0.759

High

1391332

MED8
Mediator of RNA polymerase II transcription subunit 8

9

1

Small-scale

0.757

High

1413630

MED20
Mediator of RNA polymerase II transcription subunit 20

9

1

Small-scale

0.755

High

1151290

MED1
Mediator of RNA polymerase II transcription subunit 1

9

1

Small-scale

0.754

High

1413638

MED11
Mediator of RNA polymerase II transcription subunit 11

8

1

Small-scale

0.754

High

1413631

MED4
Mediator of RNA polymerase II transcription subunit 4

8

1

Small-scale

0.752

High

666899

CCNC
Cyclin-C

9

2

Small-scale

0.751

High

1413642

MED13
Mediator of RNA polymerase II transcription subunit 13

8

2

Small-scale

0.749

High

282414

MED24
Mediator of RNA polymerase II transcription subunit 24

8

1

Small-scale

0.749

High

1413644

MED16
Mediator of RNA polymerase II transcription subunit 16

7

1

Small-scale

0.745

High

1413636

MED29
Mediator of RNA polymerase II transcription subunit 29

6

1

Small-scale

0.738

High

1413646

MED31
Mediator of RNA polymerase II transcription subunit 31

6

2

Small-scale

0.738

High

1393374

MED30
Mediator of RNA polymerase II transcription subunit 30

6

1

Small-scale

0.735

High

1241409

MED27
Mediator of RNA polymerase II transcription subunit 27

6

1

Small-scale

0.732

High

1413643

MED23
Mediator of RNA polymerase II transcription subunit 23

6

1

Small-scale

0.732

High

1413627

CDK19
Cyclin-dependent kinase 19

6

4

High-throughput

0.729

High

1149707

MED22
Mediator of RNA polymerase II transcription subunit 22

8

0

Small-scale

0.717

High

1259066

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

5

2

Small-scale

0.716

High

1259275

MED25
Mediator of RNA polymerase II transcription subunit 25

5

2

Small-scale

0.716

High

336026

MED26
Mediator of RNA polymerase II transcription subunit 26

7

0

Small-scale

0.716

High

1413635

MED9
Mediator of RNA polymerase II transcription subunit 9

6

0

Small-scale

0.701

High

1401563

MED15
Mediator of RNA polymerase II transcription subunit 15

4

2

Small-scale

0.694

High

1413628

MED28
Mediator of RNA polymerase II transcription subunit 28

5

0

High-throughput

0.688

High

621732

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

1

High-throughput

0.667

High

192850

RPB4
DNA-directed RNA polymerase II subunit RPB4

3

0

High-throughput

0.646

High

621951

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

0

High-throughput

0.646

High

667429

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

0

High-throughput

0.638

High

723070

RPB2
DNA-directed RNA polymerase II subunit RPB2

3

0

High-throughput

0.638

High

188713

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

787778

RPB9
DNA-directed RNA polymerase II subunit RPB9

2

0

High-throughput

0.585

High

912114

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

0

High-throughput

0.585

High

912221

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

0

High-throughput

0.585

High

923528

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

0

High-throughput

0.585

High

959044

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

High-throughput

0.585

High

976141

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.585

High

983696

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

0

High-throughput

0.585

High

1380126

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.585

High

1413629

TRI45
E3 ubiquitin-protein ligase TRIM45

2

0

High-throughput

0.580

High

1413637

ABI2
Abl interactor 2

2

0

High-throughput

0.580

High

507352

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

0

High-throughput

0.576

High

316311

RECQ5
ATP-dependent DNA helicase Q5

2

1

High-throughput

0.571

High

396843

ESR1
Estrogen receptor

1

3

Small-scale

0.561

High

1413625

MED10
Mediator of RNA polymerase II transcription subunit 10

2

1

Small-scale

0.552

High

1163181

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

1294988

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

2

High-throughput

0.536

High

542636

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

1243770

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1408012

H2A1J
Histone H2A type 1-J

1

0

High-throughput

0.513

High

834045

HNF4A
Hepatocyte nuclear factor 4-alpha

1

2

Small-scale

0.501

High

1367151

ESR2
Estrogen receptor beta

1

3

Small-scale

0.501

High

936845

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.486

High

260389

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

520341

ANDR
Androgen receptor

1

3

High-throughput

0.479

High

905090

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

920247

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.479

High

1089002

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1141283

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.479

High

1217607

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

2

High-throughput

0.479

High

1399344

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

3

High-throughput

0.479

High

1413632

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

3

High-throughput

0.479

High

262564

MCE1
mRNA-capping enzyme

1

0

High-throughput

0.458

High

326369

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

343034

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

348699

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

373018

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

533970

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.458

High

980246

H4
Histone H4

1

0

High-throughput

0.458

High

1151382

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1257815

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1313039

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1400064

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1407407

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

137343

ELL2
RNA polymerase II elongation factor ELL2

1

1

High-throughput

0.445

High

1096196

TADBP
TAR DNA-binding protein 43

1

1

High-throughput

0.445

High

1413641

AFF4
AF4/FMR2 family member 4

1

1

High-throughput

0.445

High

322678

KDM4B
Lysine-specific demethylase 4B

1

0

High-throughput

0.438

High

717343

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.438

High

1227371

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

141639

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

High-throughput

0.426

High

447376

NPM
Nucleophosmin

1

0

High-throughput

0.426

High

687497

PTBP1
Polypyrimidine tract-binding protein 1

1

0

High-throughput

0.426

High

761499

HS71L
Heat shock 70 kDa protein 1-like

1

0

High-throughput

0.426

High

996313

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.426

High

1127123

RBM39
RNA-binding protein 39

1

0

High-throughput

0.426

High

1144454

NONO
Non-POU domain-containing octamer-binding protein

1

0

High-throughput

0.426

High

1311718

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

0

High-throughput

0.426

High

1413639

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.426

High

1413640

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.426

High

76435

B4DUB1
cyclin-dependent kinase

1

4

High-throughput

0.407

High

95755

E5RFK5
Cyclin-C

1

2

High-throughput

0.407

High

887187

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

352638

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

402458

FUCO
Tissue alpha-L-fucosidase

2

0

High-throughput

0.316

High

1407509

GDIR3
Rho GDP-dissociation inhibitor 3

2

0

High-throughput

0.316

High

1413645

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.282

High

1247513

POTEE
POTE ankyrin domain family member E

1

0

High-throughput

0.279

Low

70846

SYC1L
Synaptonemal complex central element protein 1-like

1

0

High-throughput

0.251

Low

387556

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

1232010

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

506024

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low

953981

IF4A1
Eukaryotic initiation factor 4A-I

1

0

High-throughput

0.232

Low

1361905

TITIN
Titin

1

0

High-throughput

0.232

Low

1413634

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025