Protein: TIPRL
TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP)

Gene: TIPRL
Organism: Homo sapiens
Interactions: 72
UniProt ID: O75663

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0004864 - protein phosphatase inhibitor activity
GO:0005829 - cytosol
GO:0031929 - TOR signaling
GO:0072542 - protein phosphatase activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

289854

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

5

6

Small-scale

0.927

High

143509

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

5

7

Small-scale

0.927

High

289860

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

3

5

Small-scale

0.855

High

289857

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

2

5

Small-scale

0.812

High

289847

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

3

0

High-throughput

0.638

High

58691

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

2

0

High-throughput

0.559

High

240300

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

289849

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

289872

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

0

High-throughput

0.559

High

289861

IGBP1
Immunoglobulin-binding protein 1

1

1

Small-scale

0.515

High

289864

CUL3
Cullin-3

1

0

High-throughput

0.513

High

289885

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

0

High-throughput

0.513

High

289859

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.489

High

289879

DYT2B
Dynein light chain Tctex-type protein 2B

1

1

High-throughput

0.489

High

289840

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

169857

AURKA
Aurora kinase A

1

1

High-throughput

0.479

High

213739

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

Small-scale

0.479

High

289831

TIPRL
TIP41-like protein

1

1

High-throughput

0.479

High

289850

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

289856

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

289886

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

289834

UFL1
E3 UFM1-protein ligase 1

1

0

Small-scale

0.460

High

289836

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

289841

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

289842

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

289855

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

289858

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

289866

OZF
Zinc finger protein OZF

1

0

High-throughput

0.458

High

289869

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

289873

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

289876

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

289878

DNJA4
DnaJ homolog subfamily A member 4

1

0

High-throughput

0.458

High

289881

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

289882

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

289883

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.458

High

289884

OPTN
Optineurin

1

0

High-throughput

0.458

High

289887

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

289890

CCD39
Coiled-coil domain-containing protein 39

1

0

High-throughput

0.458

High

289867

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

289833

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.437

High

289853

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.437

High

289862

DUS8
Dual specificity protein phosphatase 8

1

1

High-throughput

0.437

High

289868

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.437

High

289877

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.437

High

142251

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.426

High

289838

PRIO
Major prion protein

1

0

High-throughput

0.426

High

289888

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

289835

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

289889

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

6

0

Small-scale

0.383

High

289837

FUCO
Tissue alpha-L-fucosidase

2

0

High-throughput

0.328

High

289880

ITLN1
Intelectin-1

2

0

High-throughput

0.328

High

66913

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.279

Low

289851

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

0

High-throughput

0.279

Low

289891

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

0

High-throughput

0.279

Low

104965

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

176015

KDM6B
Lysine-specific demethylase 6B

1

0

Small-scale

0.249

Low

289832

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

289839

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

289843

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

289844

ZKSC1
Zinc finger protein with KRAB and SCAN domains 1

1

0

High-throughput

0.249

Low

289845

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

289846

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

289848

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

289865

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

289870

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

289871

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

289874

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

0

High-throughput

0.249

Low

289892

MAFB
Transcription factor MafB

1

0

High-throughput

0.249

Low

289863

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

289875

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.232

Low

289852

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.213

Low


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Last updated: 11Aug2025