Protein: SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)

Gene: SHPS1, Sirpa
Organism: Mus musculus
Interactions: 23
UniProt ID: P97797

Gene Ontology (top 5):
GO:0002244 - hematopoietic progenitor cell differentiation
GO:0004864 - protein phosphatase inhibitor activity
GO:0005886 - plasma membrane
GO:0006910 - phagocytosis, recognition
GO:0006911 - phagocytosis, engulfment

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1021896

CD47
Leukocyte surface antigen CD47

2

3

Small-scale

0.806

High

1021895

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

10

High-throughput

0.789

High

767007

PTN11
Tyrosine-protein phosphatase non-receptor type 11

7

14

Small-scale

0.674

High

599256

GHR
Growth hormone receptor

1

12

Small-scale

0.647

High

711221

PTN6
Tyrosine-protein phosphatase non-receptor type 6

3

13

Small-scale

0.640

High

205022

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

6

High-throughput

0.618

High

723340

SSR3
Somatostatin receptor type 3

1

12

High-throughput

0.618

High

1021891

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

16

Small-scale

0.575

High

1021897

JAK2
Tyrosine-protein kinase JAK2

1

17

Small-scale

0.561

High

1021903

HOME1
Homer protein homolog 1

1

3

High-throughput

0.536

High

205171

FYB1
FYN-binding protein 1

1

8

Small-scale

0.479

High

686952

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

16

Small-scale

0.479

High

1021892

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.479

High

1021893

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.479

High

1021894

SKAP1
Src kinase-associated phosphoprotein 1

1

4

Small-scale

0.479

High

1021901

FAK2
Protein-tyrosine kinase 2-beta

1

17

Small-scale

0.479

High

450391

CSF1
Macrophage colony-stimulating factor 1

1

2

Small-scale

0.445

High

108640

G3X9H5
Huntingtin

1

1

High-throughput

0.437

High

1021898

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

5

Small-scale

0.437

High

1021899

FBX2
F-box only protein 2

1

10

Small-scale

0.437

High

1021902

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.249

Low

1021900

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025