Protein: SIR1
NAD-dependent protein deacetylase sirtuin-1 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (SIR2alpha) (Sir2) (mSIR2a) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]

Gene: SIR1, Sirt1
Organism: Mus musculus
Interactions: 68
UniProt ID: Q923E4

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000183 - rDNA heterochromatin formation
GO:0000720 - pyrimidine dimer repair by nucleotide-excision repair
GO:0000731 - DNA synthesis involved in DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

266909

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

2

1

Small-scale

0.661

High

148283

CLOCK
Circadian locomoter output cycles protein kaput

2

10

Small-scale

0.649

High

1363035

BMAL1
Basic helix-loop-helix ARNT-like protein 1

2

13

Small-scale

0.628

High

432101

JUN
Transcription factor Jun

2

4

Small-scale

0.612

High

1362945

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

12

Small-scale

0.602

High

789698

PPARG
Peroxisome proliferator-activated receptor gamma

2

20

Small-scale

0.601

High

1222543

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

11

Small-scale

0.597

High

654816

PPARA
Peroxisome proliferator-activated receptor alpha

2

20

Small-scale

0.595

High

648023

HNF1A
Hepatocyte nuclear factor 1-alpha

1

7

Small-scale

0.589

High

236762

PER2
Period circadian protein homolog 2

1

9

Small-scale

0.586

High

1045983

TF65
Transcription factor p65

2

7

Small-scale

0.584

High

148730

HDAC1
Histone deacetylase 1

1

9

Small-scale

0.561

High

609561

HXB1
Homeobox protein Hox-B1

1

10

High-throughput

0.541

High

1059028

NFE2
Transcription factor NF-E2 45 kDa subunit

1

2

High-throughput

0.541

High

542880

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.536

High

886247

HNF4A
Hepatocyte nuclear factor 4-alpha

1

14

Small-scale

0.536

High

1363038

CITE4
Cbp/p300-interacting transactivator 4

1

0

High-throughput

0.518

High

204549

SMAD7
Mothers against decapentaplegic homolog 7

1

1

Small-scale

0.515

High

370861

FOS
Protein c-Fos

1

6

Small-scale

0.515

High

578577

JUND
Transcription factor JunD

1

4

Small-scale

0.515

High

1211119

ACACA
Acetyl-CoA carboxylase 1

1

16

Small-scale

0.515

High

1222109

NCOR1
Nuclear receptor corepressor 1

1

9

Small-scale

0.515

High

1223910

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

12

Small-scale

0.515

High

1363027

SNW1
SNW domain-containing protein 1

1

2

Small-scale

0.515

High

1296849

Q8BK32
Nuclear receptor co-repressor 1

1

3

Small-scale

0.512

High

704502

RXRA
Retinoic acid receptor RXR-alpha

1

18

Small-scale

0.501

High

1363037

NCOR2
Nuclear receptor corepressor 2

1

8

Small-scale

0.501

High

63115

A5D6Q2
Nuclear receptor coactivator 3

1

13

High-throughput

0.481

High

73924

B2RR24
Zinc finger protein 236

1

2

High-throughput

0.481

High

74296

EP300
Histone acetyltransferase p300

1

11

Small-scale

0.479

High

108255

G3X8V5
ORC ubiquitin ligase 1

1

1

Small-scale

0.479

High

147642

ERR1
Steroid hormone receptor ERR1

1

15

Small-scale

0.479

High

382509

P53
Cellular tumor antigen p53

1

6

Small-scale

0.479

High

666053

PAX3
Paired box protein Pax-3

1

3

Small-scale

0.479

High

670148

NECD
Necdin

1

3

Small-scale

0.479

High

772578

IRS1
Insulin receptor substrate 1

1

12

Small-scale

0.479

High

832857

BCL6
B-cell lymphoma 6 protein homolog

1

5

Small-scale

0.479

High

936638

KMT2A
Histone-lysine N-methyltransferase 2A

1

10

Small-scale

0.479

High

1010416

IRS2
Insulin receptor substrate 2

1

11

Small-scale

0.479

High

1221279

NR1H4
Bile acid receptor

1

20

Small-scale

0.479

High

1223235

CBX5
Chromobox protein homolog 5

1

6

Small-scale

0.479

High

1225427

HEN2
Helix-loop-helix protein 2

1

5

Small-scale

0.479

High

1298636

KAT5
Histone acetyltransferase KAT5

1

5

Small-scale

0.479

High

1353988

CCAR2
Cell cycle and apoptosis regulator protein 2

1

5

Small-scale

0.479

High

1363024

ATG5
Autophagy protein 5

1

1

Small-scale

0.479

High

1363026

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

5

Small-scale

0.479

High

1363028

KAT8
Histone acetyltransferase KAT8

1

5

Small-scale

0.479

High

1363029

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

Small-scale

0.479

High

1363030

Q9DCC5
Cbx3 protein

1

6

Small-scale

0.479

High

1363031

CAF1A
Chromatin assembly factor 1 subunit A

1

5

High-throughput

0.479

High

1363032

BC11A
BCL11 transcription factor A

1

5

Small-scale

0.479

High

1363033

FOXO1
Forkhead box protein O1

1

13

Small-scale

0.479

High

1363034

HIC1
Hypermethylated in cancer 1 protein

1

6

Small-scale

0.479

High

1363036

SRBP1
Sterol regulatory element-binding protein 1

1

10

Small-scale

0.479

High

1363040

MECP2
Methyl-CpG-binding protein 2

1

3

Small-scale

0.479

High

1052202

PGH2
Prostaglandin G/H synthase 2

1

0

Small-scale

0.458

High

1053220

Q05BA5
Nuclear receptor coactivator

1

12

High-throughput

0.457

High

543035

CDK1
Cyclin-dependent kinase 1

1

6

Small-scale

0.445

High

666791

CCNB1
G2/mitotic-specific cyclin-B1

1

3

Small-scale

0.445

High

681993

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

11

Small-scale

0.445

High

1221280

NR1H2
Oxysterols receptor LXR-beta

1

20

Small-scale

0.445

High

1244002

MARE3
Microtubule-associated protein RP/EB family member 3

1

1

Small-scale

0.445

High

1298494

FTM
Protein fantom

1

8

High-throughput

0.445

High

1298577

BCOR
BCL-6 corepressor

1

11

Small-scale

0.445

High

1363025

FOXP3
Forkhead box protein P3

1

5

Small-scale

0.445

High

1363039

NR1H3
Oxysterols receptor LXR-alpha

1

20

Small-scale

0.445

High

1189976

Q3UAV3
Uncharacterized protein

1

1

High-throughput

0.417

High

1222382

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

Small-scale

0.407

High


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Last updated: 11Aug2025