Protein: TBC21
TBC1 domain family member 21 (Male germ cell Rab GTPase-activating protein)

Gene: TBC21, TBC1D21
Organism: Homo sapiens
Interactions: 33
UniProt ID: Q8IYX1

Gene Ontology (top 5):
GO:0001669 - acrosomal vesicle
GO:0003779 - actin binding
GO:0005096 - GTPase activator activity
GO:0005856 - cytoskeleton
GO:0007283 - spermatogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1315669

EVI5L
EVI5-like protein

2

6

High-throughput

0.783

High

300669

KRT37
Keratin, type I cuticular Ha7

2

9

High-throughput

0.606

High

300790

KRT38
Keratin, type I cuticular Ha8

2

9

High-throughput

0.606

High

618070

K1C15
Keratin, type I cytoskeletal 15

2

3

High-throughput

0.606

High

1009678

NGAL
Neutrophil gelatinase-associated lipocalin

2

1

High-throughput

0.606

High

1230126

K1C40
Keratin, type I cytoskeletal 40

2

9

High-throughput

0.606

High

1315668

KRT35
Keratin, type I cuticular Ha5

2

9

High-throughput

0.606

High

1315670

CFA53
Cilia- and flagella-associated protein 53

2

6

High-throughput

0.606

High

1136984

SEPT2
Septin-2

2

0

High-throughput

0.580

High

1157149

PDCD2
Programmed cell death protein 2

2

0

High-throughput

0.580

High

1315666

RIBC1
RIB43A-like with coiled-coils protein 1

2

0

High-throughput

0.580

High

1315674

KI26A
Kinesin-like protein KIF26A

2

1

High-throughput

0.561

High

570496

GFAP
Glial fibrillary acidic protein

2

6

High-throughput

0.553

High

1048910

REL
Proto-oncogene c-Rel

2

2

High-throughput

0.553

High

1315671

RAB3I
Rab-3A-interacting protein

2

1

High-throughput

0.553

High

1315675

SNX7
Sorting nexin-7

2

1

High-throughput

0.553

High

422547

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

1232449

Q6FHY5
MEOX2 protein

1

5

High-throughput

0.470

High

1237994

Q6NSM0
NR1D2 protein

1

4

High-throughput

0.470

High

894000

MEOX2
Homeobox protein MOX-2

1

4

High-throughput

0.439

High

1134831

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

4

High-throughput

0.439

High

1208148

CD158
Coiled-coil domain-containing protein 158

1

2

High-throughput

0.439

High

230686

GAS2
Growth arrest-specific protein 2

2

0

High-throughput

0.316

High

708909

T2EA
General transcription factor IIE subunit 1

2

0

High-throughput

0.316

High

967263

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

2

0

High-throughput

0.316

High

1240748

PMF1
Polyamine-modulated factor 1

2

0

High-throughput

0.316

High

1315672

HTF4
Transcription factor 12

2

0

High-throughput

0.316

High

1315673

STMN3
Stathmin-3

2

0

High-throughput

0.316

High

1315676

SMAG1
Protein Smaug homolog 1

2

0

High-throughput

0.316

High

1315667

O52N4
Olfactory receptor 52N4

1

0

High-throughput

0.279

Low

332535

CCDB1
Cyclin-D1-binding protein 1

1

0

High-throughput

0.269

Low

1294612

NUTM1
NUT family member 1

1

0

High-throughput

0.251

Low

321299

ERLN2
Erlin-2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025